Patents by Inventor Guo-Jie Ho

Guo-Jie Ho has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for preparing peptide intermediates
    Patent number: 7262169
    Abstract: The present invention is directed to the improved synthesis of compounds of formula (I) an intermediate compound which is useful in the synthesis of the anticancer agents known as PSA conjugates.
    Type: Grant
    Filed: October 18, 2000
    Date of Patent: August 28, 2007
    Assignees: Merck & Co., Inc., Merck Sharp & Dohme Limited
    Inventors: Michael Stewart Ashwood, Brian Christopher Bishop, Ian Frank Cottrell, Khateeta Moneek Emerson, David Hands, Guo Jie Ho, Joseph Edward Lynch, Yao Jun Shi, Robert Darrin Wilson
  • Process for making substituted 8-arylquinolinium benzenesulfonate
    Patent number: 6835837
    Abstract: A substituted 8-aryl quinoline and its benzenesulfonic acid salt is synthesized.
    Type: Grant
    Filed: May 15, 2003
    Date of Patent: December 28, 2004
    Assignee: Merck & Co. Inc.
    Inventors: Richard Desmond, David A. Conlon, Antoinette Drahus, Guo-Jie Ho, Brenda Pipik, Carl Leblond, Anant Vailaya
  • Substituted 8-arylquinoline phosphodiesterase-4 inhibitors
    Patent number: 6740666
    Abstract: Novel sulfuric acid, methanesulfonic acid, p-toluenesulfonic acid, 2-naphthalenesulfonic acid, hydrochloride acid, or benzenesulfonic acid salts of substituted 8-arylquinolines, wherein the aryl group at the 8-position contains a substituent substituted-alkenyl group, are PDE4 inhibitors.
    Type: Grant
    Filed: November 9, 2001
    Date of Patent: May 25, 2004
    Assignees: Merck & Co., Inc., Merck Frosst Canada & Co.
    Inventors: Dwight Macdonald, Helene Perrier, Roch Thibert, Guo-Jie Ho, Anant Vailaya, David Conlon, Elizabeth Kwong, Sophie-Dorothee Clas
  • Process for making substituted 8-arylquinolinium benzenesulfonate
    Publication number: 20040044213
    Abstract: A substituted 8-aryl quinoline and its benzenesulfonic acid salt is synthesized.
    Type: Application
    Filed: May 15, 2003
    Publication date: March 4, 2004
    Inventors: Richard Desmond, David A. Conlon, Antoinette Drahus, Guo-Jie Ho, Brenda Pipik, Carl Leblond, Anant Vailaya
  • Process for making substituted 8-arylquinolinium benzenesulfonate
    Publication number: 20030097001
    Abstract: A substituted 8-aryl quinoline and its benzenesulfonic acid salt is synthesized.
    Type: Application
    Filed: December 18, 2001
    Publication date: May 22, 2003
    Inventors: Richard Desmond, David A. Conlon, Antoinette Drahus, Guo-Jie Ho, Brenda Pipik, Carl Leblond, Anant Vailaya
  • Substituted 8-arylquinoline phosphodiesterase-4 inhibitors
    Publication number: 20020143032
    Abstract: Novel sulfuric acid, methanesulfonic acid, p-toluenesulfonic acid, 2-naphthalenesulfonic acid, hydrochloride acid, or benzenesulfonic acid salts of substituted 8-arylquinolines, wherein the aryl group at the 8-position contains a substituent substituted-alkenyl group, are PDE4 inhibitors.
    Type: Application
    Filed: November 9, 2001
    Publication date: October 3, 2002
    Inventors: Dwight Macdonald, Helene Perrier, Roch Thibert, Guo-Jie Ho, Anant Vailaya, David Conlon, Elizabeth Kwong, Sophie-Dorothee Clas
  • Synthesis of substituted prolines
    Patent number: 6350882
    Abstract: The instant invention is directed to a process for synthesizing substituted prolines, in particular, optically pure substituted prolines, which comprises the steps of: a) adding an unsubstituted or substituted proline alkali salt and an alkali halide to a solution of dialkylacylamidomalonate; and b) adding &agr;, &bgr; unsaturated aldehyde to produce an adduct.
    Type: Grant
    Filed: May 5, 2000
    Date of Patent: February 26, 2002
    Assignee: Merck & Co., Inc.
    Inventors: Khateeta Emerson, Guo-Jie Ho
  • Therapeutic polymorphs of a GABA-A alpha-5 inverse agonist and pamoate formulations of the same
    Publication number: 20010049439
    Abstract: There is disclosed 3-(5-methylisoxazol-3-yl)-6-(1-methyl-1,2,3-triazol-4-yl)methyloxy-1,2,4-triazolo[3,4-a]phthalazine in the form of a dihydrate, a dehydrate of the dihydrate and a pentahydrate, pharmaceutical compositions comprising the forms, the use of the forms for enhancing cognition, processes for producing the forms, their incorporation in pharmaceutical compositions comprising pamoate ions and the use of such ions for solubilizing neutral molecules.
    Type: Application
    Filed: November 30, 2000
    Publication date: December 6, 2001
    Applicant: Merck & Co., Inc.
    Inventors: Michael J. Kaufman, James A. McCauley, Daniel J. Rush, David M. Tschaen, Richard J. Varsolona, Guo-Jie Ho
  • Intermediates for making heterocycles useful as COX-2 inhibitors
    Patent number: 6153787
    Abstract: The invention encompasses a process for making compounds of Formula I or Ia useful in the treatment of cyclooxygenase-2 mediated diseases.
    Type: Grant
    Filed: December 4, 1998
    Date of Patent: November 28, 2000
    Assignee: Merck & Co., Inc.
    Inventors: Kai Rossen, Guo-Jie Ho, Ralph P. Volante, Roger N. Farr, David J. Mathre
  • Process for making phenyl heterocycles useful as cox-2 inhibitors
    Patent number: 5883267
    Abstract: The invention encompasses a process for making compounds of Formula I or Ia useful in the treatment of cyclooxygenase-2 mediated diseases.
    Type: Grant
    Filed: May 6, 1997
    Date of Patent: March 16, 1999
    Assignee: Merck & Co., Inc.
    Inventors: Kai Rossen, Ralph P. Volante, Guo-Jie Ho, Roger N. Farr, David J. Mathre
  • Process for peptide segment condensation
    Patent number: 5773575
    Abstract: The present invention is drawn to a process for forming an amide bond linkage comprising reacting a carboxylic acid and an amine in a two-phase mixture of water and an organic solvent selected from an oxygenated organic solvent or an aromatic solvent in the presence of a coupling reagent and an additive. This process is useful for making ubiquitous amides and polypeptides having various biological activities.
    Type: Grant
    Filed: October 1, 1996
    Date of Patent: June 30, 1998
    Assignee: Merck & Co., Inc.
    Inventors: Guo-Jie Ho, David J. Mathre, Zhiguo Song, Khateeta Emerson
  • Process to derivatives of piperizinylcamphorsulfonyl oxytocin antagonists
    Patent number: 5693805
    Abstract: A process for the manufacture of oxytocin receptor antagonists of the following formula (I) ##STR1## and their crystalline salts is disclosed.
    Type: Grant
    Filed: September 12, 1995
    Date of Patent: December 2, 1997
    Assignee: Merck & Co., Inc.
    Inventors: Anthony M. DeMarco, Edward J.J. Grabowski, Guo-Jie Ho, David J. Mathre, Khateeta M. Emerson, Richard F. Shuman, Paul Sohar
  • Boronic acid compound
    Patent number: 5618934
    Abstract: The present invention is directed to a compound represented by the structural formula: ##STR1## wherein Z-- represents a negatively charged counterion.
    Type: Grant
    Filed: February 27, 1995
    Date of Patent: April 8, 1997
    Assignee: Merck & Co., Inc.
    Inventors: Ann E. DeCamp, Edward J. J. Grabowski, Mark A. Huffman, Lyndon C. Xavier, Nobuyoshi Yasuda, Guo-Jie Ho, David J. Mathre
  • Process of synthesizing N-acyl auxiliaries
    Patent number: 5594134
    Abstract: A process of synthesizing N-acyl auxiliary compounds is disclosed. A compound of the formula: ##STR1## is reacted with an anhydride in the presence of a lithium salt and an amine base to produce the N-acylated auxiliary.
    Type: Grant
    Filed: March 31, 1995
    Date of Patent: January 14, 1997
    Assignee: Merck & Co., Inc.
    Inventors: Guo-Jie Ho, David J. Mathre
  • Process for peptide segment condensation
    Patent number: 5502165
    Abstract: The present invention is drawn to a process for forming an amide bond linkage comprising reacting a carboxylic acid and an amine in a two-phase mixture of water and an organic solvent selected from an oxygenated organic solvent or an aromatic solvent in the presence of a coupling reagent and an additive. This process is useful for making ubiquitous amides and polypeptides having various biological activities.
    Type: Grant
    Filed: April 4, 1994
    Date of Patent: March 26, 1996
    Assignee: Merck & Co., Inc.
    Inventors: Guo-Jie Ho, David A. Mathre, Zhiguo Song, Khateeta Emerson
  • Process of synthesizing n-acyl auxiliaries
    Patent number: 5461162
    Abstract: A process of synthesizing N-acyl auxiliary compounds is disclosed. A compound of the formula: ##STR1## is reacted with an anhydride in the presence of a lithium salt and an amine base to produce the N-acylated auxiliary.
    Type: Grant
    Filed: July 27, 1994
    Date of Patent: October 24, 1995
    Assignee: Merck & Co., Inc.
    Inventors: Guo-Jie Ho, David J. Mathre