Patents by Inventor Guokai Feng

Guokai Feng has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 12224809
    Abstract: Disclosed are an OTA test method for a vehicle antenna system, a device and a storage medium. According to the method, the radio frequency performance of a physical layer of a whole vehicle antenna system can be tested, and the problem in the prior art that the test result of parts cannot accurately reflect the performance of the whole vehicle antenna system can be solved.
    Type: Grant
    Filed: June 27, 2024
    Date of Patent: February 11, 2025
    Assignees: CHINA AUTOMOTIVE TECHNOLOGY AND RESEARCH CENTER CO., LTD., CATARC AUTOMOTIVE TEST CENTER (TIANJIN) CO., LTD., CATARC AUTOMOTIVE TEST CENTER (GUANGZHOU) CO., LTD.
    Inventors: Guotian Ji, Hang Sun, Jinfeng Gong, Zhao Wang, Hui Rong, Guokai Jiang, Jiaxu Feng, Hanbing Wu, Yifu Ding, Zhiruo Zhang
  • Patent number: 12223839
    Abstract: A testing method for a blind spot detection system for an automobile includes: applying an electromagnetic interference signal to the tested automobile through an electromagnetic interference signal application device, meanwhile, simulating a static obstacle or a moving obstacle within a detection range through a testing device, and if the blind spot detection system for the tested automobile is activated, determining that the testing is passed. Repeatable and reproducible testing for the electromagnetic safety of the blind spot detection system may be realized.
    Type: Grant
    Filed: June 27, 2024
    Date of Patent: February 11, 2025
    Assignees: CHINA AUTOMOTIVE TECHNOLOGY AND RESEARCH CENTER CO., LTD., CATARC NEW ENERGY VEHICLE TEST CENTER (TIANJIN) CO., LTD., CATARC AUTOMOTIVE TEST CENTER (TIANJIN) CO., LTD.
    Inventors: Guotian Ji, Jinfeng Gong, Hang Sun, Zhao Wang, Hui Rong, Xu Zhang, Guangyu Zhang, Guokai Jiang, Yunlei Zhang, Yan Fan, Jiaxu Feng, Hanbing Wu, Liang Huang, Jiarui Zhang, Jingjing Hao
  • Publication number: 20240342320
    Abstract: A polypeptide targeting integrin ?6 and the use thereof. The polypeptide has a sequence motif of RWYD, and is stronger in affinity, wherein the equilibrium dissociation constant KD reaches the level of nM, and the affinity is greatly improved. The polypeptide has a strong affinity to integrin ?6, a strong specificity and no biological toxicity, is relatively stable in vivo and reasonable in distribution, and can be used as a targeting carrier. In addition, the polypeptide targeting integrin ?6 can be used as a molecular probe in the molecular imaging of various tumors with highly-expressed integrin ?6. Further provided is a dimer of the polypeptide, which has a more significant targeting effect and no biological toxicity. The polypeptide targeting integrin ?6 can be used in the molecular imaging of various tumors with highly-expressed integrin ?6, and has an important application value in the molecular imaging of tumors.
    Type: Application
    Filed: July 6, 2021
    Publication date: October 17, 2024
    Inventors: Musheng ZENG, Guokai FENG, Jiacong YE
  • Patent number: 12098167
    Abstract: The present invention is related to a self-assembled nanoparticle containing a gB protein of an EB virus and a preparation method and use thereof. The self-assembled nanoparticle comprises a first polypeptide and a second polypeptide; the first polypeptide comprises the gB protein and a first vector subunit, the second polypeptide comprises a second vector subunit; the first vector subunit is I53-50A1, and the second vector subunit is I53-50B.4PT1. In the self-assembled nanoparticle, the gB protein of the EB virus is displayed on the surface of the nanoparticle for the first time. The particle size of the self-assembled nanoparticle is larger than that of the antigen gB, and the chemical stability of the self-assembled nanoparticle is higher than that of the antigen gB, and the binding capacity with the neutralizing antibody of the self-assembled nanoparticle are higher than that of the antigen gB.
    Type: Grant
    Filed: December 15, 2020
    Date of Patent: September 24, 2024
    Assignees: SUN YAT-SEN UNIVERSITY, SUN YAT-SEN UNIVERSITY CANCER CENTER (SYSUCC)
    Inventors: Musheng Zeng, Cong Sun, Yixin Zeng, Guokai Feng, Yinfeng Kang, Xinchun Chen, Xiao Zhang, Qianying Zhu, Jiangping Li, Xiangwei Kong
  • Publication number: 20240309050
    Abstract: Disclosed is a self-assembled nanoparticle containing a gHgL protein of an EB virus, a preparation method and use thereof. The self-assembled nanoparticle comprises a first polypeptide and a second polypeptide, wherein the first polypeptide comprises a gHgL protein and a first vector subunit, and the second polypeptide comprises a second vector subunit; the first vector subunit is 153-50A1, and the second vector subunit is 153-50B.4PT1; and the gHgL protein is linked to the first vector subunit through a linker. The gHgL protein of the EB virus is displayed on a surface of the self-assembled nanoparticle for the first time. The self-assembled nanoparticle has a larger particle size than the antigen (gHgL), a better antigen residence volume, and a thermal stability comparable to the antigen (gHgL). Moreover, since a larger number of gHgLs are displayed, the self-assembled nanoparticle can strongly stimulate more B cells and induce higher antibody titer.
    Type: Application
    Filed: September 1, 2021
    Publication date: September 19, 2024
    Inventors: Musheng ZENG, Cong SUN, Guokai FENG, Yinfeng KANG
  • Publication number: 20240058441
    Abstract: Disclosed are a fusion protein, and a preparation method and use thereof, which belong to the field of biomedicine technologies. The fusion protein comprises a polypeptide specifically bound to a KRas protein, a specific tumor-cell-penetrating peptide and a lysosome recognition peptide. The fusion protein with tumor targeting, penetrability and specific protein degradation is designed and constructed direct to an undruggable protein for the first time, thus providing a new idea for development of an anti-cancer targeted drug. Different from the prior art in which one molecule can only target one target protein, the fusion protein can simultaneously induce degradation of wild-type and mutant-type KRas proteins. Meanwhile, the fusion protein can improve the sensitivity of the KRas mutant-type tumor to the tumor-targeted drug by inducing degradation of KRas, thus expanding an application range of existing anti-cancer targeted drugs and having important significance in tumor clinic treatment.
    Type: Application
    Filed: May 18, 2021
    Publication date: February 22, 2024
    Inventors: Musheng Zeng, Jie Yang, Guokai Feng, Qiaoli Wang
  • Publication number: 20240034755
    Abstract: Disclosed are a self-assembled nanoparticle containing a gB protein of an EB virus and a preparation method and use thereof The self-assembled nanoparticle comprises a first polypeptide and a second polypeptide; the first polypeptide comprises the gB protein and a first vector subunit, the second polypeptide comprises a second vector subunit; the first vector subunit is I53-50A1, and the second vector subunit is I53-50B.4PT1. In the self-assembled nanoparticle provided herein, the gB protein of the EB virus is displayed on the surface of the nanoparticle for the first time. The particle size of the self-assembled nanoparticle is larger than that of the antigen gB, and the chemical stability of the self-assembled nanoparticle is higher than that of the antigen gB, and the binding capacity with the neutralizing antibody of the self-assembled nanoparticle are higher than that of the antigen gB.
    Type: Application
    Filed: December 16, 2020
    Publication date: February 1, 2024
    Inventors: Musheng ZENG, Cong SUN, Yixin ZENG, Guokai FENG, Yinfeng KANG, Xinchun CHEN, Xiao ZHANG, Qianying ZHU, Jiangping LI, Xiangwei KONG
  • Publication number: 20210017231
    Abstract: The invention discloses an ATP1A1-targeting polypeptide and the use thereof. The motif of the ATP1A1-targeting polypeptide is represented by the general formula of SISSLTH, and the C- and/or N-terminal(s) of the motif is/are optionally linked with 1-3 amino acids. It is demonstrated by experiments that the ATP1A1-targeting polypeptide can target ATP1A1 well, and has great application value in the molecular diagnosis and targeted therapy of tumors.
    Type: Application
    Filed: February 2, 2018
    Publication date: January 21, 2021
    Inventors: Musheng Zeng, Guokai Feng, Qian Wang, Xiaoxuan Ye, Wei Xiao, Manzhi Li
  • Patent number: 9809622
    Abstract: A tumor-targeting peptide is disclosed. This tumor-targeting peptide comprises a typical motif with the general formula of: XX(Y/F) (D/E) (D/E) XX. The motif is selectively connected with 1-3 amino acids at the C-terminal and/or N-erminal. X represents any one of the twenty natural amino acids or the D type amino acids. The present invention also discloses that the peptide can not only target tumor vessels and tumor cells but also penetrate them and thus can be applied in tumor diagnosis and therapy.
    Type: Grant
    Filed: September 5, 2014
    Date of Patent: November 7, 2017
    Assignee: Sun Yat-Sen University Cancer Center
    Inventors: Musheng Zeng, Xing Zhang, Jun Wang, Guokai Feng, Mengqing Zhang, Qian Zhong
  • Publication number: 20160355548
    Abstract: This invention provides a tumor-targeting peptide. This tumor-targeting peptide comprises a typical motif with the general formula of: XX(Y/F) (D/E) (D/E) XX. The motif is selectively connected with 1-3 amino acids at the C-terminal and/or N-terminal. X represents any one of the twenty natural amino acids or the D type amino acids. The present invention also discloses that the peptide can not only target tumor vessels and tumor cells but also penetrate them and thus can be applied in tumor diagnosis and therapy.
    Type: Application
    Filed: September 5, 2014
    Publication date: December 8, 2016
    Inventors: Musheng Zeng, Xing Zhang, Jun Wang, Guokai Feng, Mengqing Zhang, Qian Zhong