Abstract: The present invention provides compounds, or pharmaceutically acceptable salts, esters, optical isomers, stereoisomers, polymorphs, solvates, N-oxides, isotopically labeled compounds, metabolites, chelates, complexes, clathrates, or prodrugs thereof, and pharmaceutical compositions containing the compounds of the invention. Also provides the application of the compounds in preparing SHP2 phosphatase related disease medicaments. The present invention also provides a method for treating a SHP2 phosphatase-Related disease.

Abstract: Provided is the following compound or a pharmaceutically acceptable salt, ester, optical isomer, stereoisomer, polymorphic substance, solvate, N-oxide, isotope-labeled compound, metabolite, chelate, coordination complex, inclusion compound or prodrug thereof, and a pharmaceutical composition comprising the compound. Also provided is an application of the compound in preparing a drug for a disease associated with SHP2 phosphatase. Also provided is a method for treating a disease associated with SHP2 phosphatase.

Abstract: The present disclosure provides preparation method for water-soluble magnolol derivatives and honokiol derivatives and intermediates thereof, and related monohydroxy protection intermediates. The nitrification intermediate has a structure shown in Formula I. Formula I is R2 is a hydroxyl, and R3 is H; or, R2 is H, and R3 is a hydroxyl; and R1 and R4 are independently selected from C1˜C12 electron donor groups. The preparation method includes the following steps: performing monohydroxy protection on a compound A with a hydroxy protection reagent in the presence of an acid binding agent to form a monohydroxy protection compound, herein R1, R2, R3 and R4 in the compound A have the same definition as above, and the hydroxy protection reagent is p-toluenesulfonyl chloride and 1-hydroxybenzotriazole; and performing a nitrification reaction and a deprotection reaction on the monohydroxy protection compound successively to obtain the nitrification intermediate.