Abstract: Compositions are disclosed that include a combination of at least one histone deacetylase inhibitor with at least one DNA or histone methyltransferase inhibitor. The combination of the histone deacetylase inhibitor with the methyltransferase inhibitor synergistically induces antimicrobial host defense peptide gene expression.

Abstract: The present disclosure provides a large-scale low-temperature controllable atmospheric boundary layer test system and method for wind and snow simulation. The system includes an atmospheric boundary layer wind tunnel, a plenum chamber and a refrigeration system. The atmospheric boundary layer wind tunnel includes an upper flow channel and a lower flow channel communicating with each other end to end. A power section is arranged in the upper flow channel. A settling chamber, a contraction section and a test section are sequentially arranged in the lower flow channel. Corners of a closed return wind tunnel are respectively provided with a transition section. A fan is disposed in the power section. An air heat exchanger is disposed in the settling chamber. The plenum chamber is divided by a partition into a storage room for storing snow particles and an operation room provided with a snow particle vibratory spreading device. The storage room is located at an upper part of the settling chamber.

Abstract: The present disclosure provides a large-scale low-temperature controllable atmospheric boundary layer test system and method for wind and snow simulation. The system includes an atmospheric boundary layer wind tunnel, a plenum chamber and a refrigeration system. The atmospheric boundary layer wind tunnel includes an upper flow channel and a lower flow channel communicating with each other end to end. A power section is arranged in the upper flow channel. A settling chamber, a contraction section and a test section are sequentially arranged in the lower flow channel. Corners of a closed return wind tunnel are respectively provided with a transition section. A fan is disposed in the power section. An air heat exchanger is disposed in the settling chamber. The plenum chamber is divided by a partition into a storage room for storing snow particles and an operation room provided with a snow particle vibratory spreading device. The storage room is located at an upper part of the settling chamber.

Abstract: Disclosed is a method for adaptive identification of erroneous GPS observed value, including: acquiring positioning information of a vehicle from a GPS sensor, and extracting first observed value data; acquiring posture information and speed information of the vehicle to acquire dead reckoning trajectory data of the vehicle; eliminating the erroneous GPS observed values based on respective data on data status value, heading significant bit, the number of satellites used and horizontal dilution of precision in the first observed value data to obtain second observed value data; constructing pose graph data based on the second observed value data and acquiring processing result information; analyzing and optimizing the processing result information to eliminate the erroneous GPS observed values of which the cost function exceeds a preset cost function threshold to obtain third observed value data; and constructing a high-precision map based on the third observed value data and three-dimensional scene map data.

Abstract: Disclosed is a method for adaptive identification of erroneous GPS observed value, including: acquiring positioning information of a vehicle from a GPS sensor, and extracting first observed value data; acquiring posture information and speed information of the vehicle to acquire dead reckoning trajectory data of the vehicle; eliminating the erroneous GPS observed values based on respective data on data status value, heading significant bit, the number of satellites used and horizontal dilution of precision in the first observed value data to obtain second observed value data; constructing pose graph data based on the second observed value data and acquiring processing result information; analyzing and optimizing the processing result information to eliminate the erroneous GPS observed values of which the cost function exceeds a preset cost function threshold to obtain third observed value data; and constructing a high-precision map based on the third observed value data and three-dimensional scene map data.

Abstract: Provided herein are small-molecule compounds and combinations thereof that enhance the synthesis of animal endogenous genus host defense peptides, which display potent antimicrobial and immunomodulatory activities. They thus represent alternatives to antibiotics for disease control and prevention for use in animals and humans. Examples of the small molecule compounds include histone deacetylase inhibitors, mono- and disaccharide sugars, cyclic adenosine monophosphate (cAMP) signaling agonists, and cyclooxygenase -2 (COX-2) inhibitors. Synergistic combinations include short-chain fatty acids, their chemical analogs or histone deacetylase inhibitors with other fatty acids, sugars, cAMP signaling agonists, and/or COX-2 inhibitors.

Abstract: According to an embodiment there is provided a method of developing catalysts that are able to reduce the levels of tars in the syngas by reforming. One embodiment develops a co-catalyst, char supported nickel catalyst, for syngas conditioning. Biomass-derived char does not only serve as a support, but also plays a role in catalyzing the reactions. Biomass-derived char is a byproduct of biomass thermo-conversion process. In one variation, hydrazine was used to reduce supported Ni2 into Ni0. Compared with the traditional method of reducing nickel with hydrogen flow, this reduction method increases nickel dispersion rate and reduces nickel particle size.

Abstract: Antimicrobial peptides and methods for their use are provided. The peptides are optimized, truncated versions of chicken cathelicidins (“fowlicidins”).

Abstract: An antimicrobial peptide and its analogs that are insensitive to physiological salt and divalent cation concentrations is provided, as are methods for their use to treat and prevent bacterial infections. The peptides are especially useful to treat infections caused by bacteria that are resistant to traditional antibiotic therapy.

Abstract: An antimicrobial peptide and its analogs that are insensitive to physiological salt and divalent cation concentrations is provided, as are methods for their use to treat and prevent bacterial infections. The peptides are especially useful to treat infections caused by bacteria that are resistant to traditional antibiotic therapy.

Abstract: Antimicrobial peptides and methods for their use are provided. The peptides are optimized, truncated versions of chicken cathelicidins (“fowlicidins”).

Abstract: An antimicrobial peptide and its analogs that are insensitive to physiological salt and divalent cation concentrations is provided, as are methods for their use to treat and prevent bacterial infections. The peptides are especially useful to treat infections caused by bacteria that are resistant to traditional antibiotic therapy.