Patents by Inventor Guoming Li

Guoming Li has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20240100015
    Abstract: The present disclosure provides an arctigenin liquid nano-preparation and a preparation method thereof, and relates to the technical field of pharmaceutical preparation. In the present disclosure, arctigenin is prepared into a liquid nano-preparation, having advantages of distribution of a droplet diameter on nanoscale, significantly increased specific surface area, rapid absorption, and high bioavailability. Meanwhile, nano-preparation entered the body can be captured by wandering leucocytes, and a medicament is delivered to inflammatory lesions through chemiotaxis, thereby conferring a targeted drug delivery feature on the arctigenin and making a therapy more targeted. Moreover, in the present disclosure, the arctigenin is dissolved in an oil phase, and the oil phase is dissolved in water by emulsification to further make the arctigenin dissolve in the water and increase water solubility of the arctigenin.
    Type: Application
    Filed: November 16, 2022
    Publication date: March 28, 2024
    Inventors: Bin HE, Lijun WU, Zheng LU, Zhiping RAN, Guoming CHEN, Zhiyong SHAO, Xiabing CHEN, Wei LIU, Ying LI, Wu LIU, Qi ZHOU, Wenhai YANG, Dongqing LIU, Kangyu DU
  • Publication number: 20240091739
    Abstract: Provided are a mercapto group-loaded layered double hydroxide (LDH)-based magnetic composite particle, and a preparation method and use thereof. The method includes: dissolving a water-soluble divalent magnesium salt and a water-soluble trivalent aluminum salt in water to obtain a mixed salt solution; pumping ammonia water into the mixed salt solution, and performing reaction I under stirring, subjecting an obtained product to centrifugation, and washing product obtained with deionized water; mixing the product with water, ethanol, and a coupling agent KH-580 to obtain a mixture, subjecting the mixture to reaction II while stirring to obtain mercapto group-loaded LDH; mixing the mercapto group-loaded LDH with ferroferric oxide and sodium alginate, adding deionized water thereto, and stirring to obtain a homogeneous mixed solution; adding the homogeneous mixed solution into a calcium chloride solution dropwise to form a magnetic bead; and leaving the magnetic bead to harden, and then washing and drying.
    Type: Application
    Filed: September 8, 2023
    Publication date: March 21, 2024
    Applicants: Institute of Soil Science, CAS, China Construction Eighth Engrg Division Corp, Ltd.
    Inventors: Yongming LUO, Guoming Liu, Chen Tu, Shuai Yang, Xiangfeng Huang, Zhongyuan Li, Runlai Luo
  • Patent number: 11911257
    Abstract: An implant delivery tube fitting (12) and an implant delivery system. The implant delivery tube fitting (12) is used for loading and delivering an implant, and the implant delivery tube fitting (12) comprises, sequentially from a proximal end to a distal end, an outer tube (122) and a capsule (121). The inner lumen of the capsule (121) is adapted to receive an implant, and the capsule (121) is provided at the distal end of the outer tube (122). The capsule (121) has a telescopic structure, and the outer tube (122) can drive the capsule (121) to make a telescopic movement so that the capsule (121) is lengthened or shortened.
    Type: Grant
    Filed: May 31, 2019
    Date of Patent: February 27, 2024
    Assignee: SHANGHAI MICROPORT CARDIOFLOW MEDTECH CO., LTD.
    Inventors: Xuwen Wu, Baozhu Gui, Xiang Liu, Jing Zhao, Guoming Chen, Yu Li
  • Publication number: 20220251149
    Abstract: The present disclosure provides a pea peptide with auxiliary hypoglycemic function, and preparation method and application thereof. The pea peptide includes at least peptide segments pEE, pEK and pER in its composition; and based on a mass of the pea peptide, a content of the peptide segment pEE is ?100.00 mg/100 g, a content of the peptide segment pEK is ?80.00 mg/100 g and a content of the peptide segment pER is ?90.00 mg/100 g. The pea peptide has a significant efficacy in an aspect of reducing blood glucose.
    Type: Application
    Filed: April 26, 2022
    Publication date: August 11, 2022
    Inventors: MUYI CAI, Ruizeng GU, LIANG CHEN, YUCHEN WANG, WENYING LIU, YUQING WANG, JING WANG, LU LU, YAGUANG XU, YING WEI, GUOMING LI, XIUYUAN QIN
  • Publication number: 20210324428
    Abstract: A Lactobacillus paracasei and uses thereof. The Lactobacillus paracasei has a deposit number of CGMCC No. 14813. The Lactobacillus paracasei can be used for increasing the amount of an organic acid in a raw material. The Lactobacillus paracasei can be used for fermenting the raw material, where the raw material can be selected from at least one of fruits, which can increase the content of the organic acid in a fermented product.
    Type: Application
    Filed: June 30, 2021
    Publication date: October 21, 2021
    Inventors: MUYI CAI, Ruizeng GU, Jun LU, KONG LING, LU LU, MING ZHOU, XINYUE CUI, XINGCHANG PAN, ZHE DONG, YONG MA, YAGUANG XU, YONGQING MA, LIANG CHEN, YING WEI, HAIXIN ZHANG, YAN LIU, KELU CAO, JING WANG, GUOMING LI, YUCHEN WANG, YUQING WANG, YUAN BI, XIUYUAN QIN
  • Patent number: 11129241
    Abstract: The utility model discloses a ceramic heating element with multiple temperature zones, which comprises a ceramic heating element. The ceramic heating element consists of a first ceramic substrate, a second ceramic substrate, a heating circuit, an electrode pad, a heating temperature zone, an independent electrode lead and a common electrode, the first ceramic substrate and the second ceramic substrate are stacked and rolled to form a cylindrical or elliptic structure with a center hole, the heating circuit is printed on a front face of the second ceramic substrate, a plurality of electrode pads are printed on a back face of the second ceramic substrate, and a plurality of through holes are machined on an upper surface of the second ceramic substrate. The utility model has the beneficial effects of a simple structure and strong practicability.
    Type: Grant
    Filed: June 5, 2018
    Date of Patent: September 21, 2021
    Inventor: Guoming Li
  • Publication number: 20210230225
    Abstract: A selenium-chelating pea oligopeptide, a preparation method thereof and use thereof. After the selenium-chelating pea oligopeptide is subjected to digestion treatment in at least one of following three ways, a change rate of selenium content not more than 3% with respect to the selenium content before the digestion treatment: hydrolyzing for 4 hours by a pepsin at a pH value of 2 and a temperature of 37° C.; hydrolyzing for 6 hours by a trypsin at a pH value of 7.5 and a temperature of 37° C.; maintaining the temperature constant at 37° C., firstly hydrolyzing for 4 hours by the pepsin at a pH value of 2, and then continuing to hydrolyze for 6 hours by a trypsin at a pH value of 6.8. The preparation method thereof includes mixing and reacting an aqueous solution of pea oligopeptide and sodium selenite, and then being subjected to alcohol precipitation and drying.
    Type: Application
    Filed: April 9, 2021
    Publication date: July 29, 2021
    Inventors: MUYI CAI, Ruizeng GU, Jun LU, WENYING LIU, XIUYUAN QIN, XINGCHANG PAN, ZHE DONG, YONG MA, YAGUANG XU, YONGQING MA, LIANG CHEN, LU LU, HAIXIN ZHANG, YING WEI, YAN LIU, KELU CAO, JING WANG, GUOMING LI, MING ZHOU, YUCHEN WANG, YUQING WANG, KONG LING, YUAN BI, XINYUE CUI
  • Publication number: 20190274357
    Abstract: The utility model discloses a ceramic heating element with multiple temperature zones, which comprises a ceramic heating element. The ceramic heating element consists of a first ceramic substrate, a second ceramic substrate, a heating circuit, an electrode pad, a heating temperature zone, an independent electrode lead and a common electrode, the first ceramic substrate and the second ceramic substrate are stacked and rolled to form a cylindrical or elliptic structure with a center hole, the heating circuit is printed on a front face of the second ceramic substrate, a plurality of electrode pads are printed on a back face of the second ceramic substrate, and a plurality of through holes are machined on an upper surface of the second ceramic substrate. The utility model has the beneficial effects of a simple structure and strong practicability.
    Type: Application
    Filed: June 5, 2018
    Publication date: September 12, 2019
    Inventor: Guoming LI
  • Patent number: 9974321
    Abstract: Disclosed are a fish protein oligopeptide with low allergenicity and slight fishiness, and industrial preparation method and application thereof. The method comprises the following steps: 1) washing fresh fish flesh and/or fish wastes, crushing, and adding water to obtain a mixture; 2) performing thermal denaturation on the mixture to obtain a denaturized protein solution; 3) centrifuging the denaturized protein solution to obtain a precipitate, and adding water into the precipitate and grinding, to obtain a slurry; 4) adjusting the slurry to pH 6-9, and sequentially adding a neutral protease, a papain and an alkaline protease to conduct enzymolysis, and after enzyme inactivation, to obtain an enzymatic hydrolysate; 5) centrifuging the enzymatic hydrolysate, and performing membrane filtration on centrifuged supernatant, to obtain the fish protein oligopeptide with low allergenicity and slight fishiness.
    Type: Grant
    Filed: February 24, 2017
    Date of Patent: May 22, 2018
    Assignee: CHINA NATIONAL RESEARCH INSTITUTE OF FOOD AND FERMENTATION INDUSTRIES
    Inventors: Muyi Cai, Ruizeng Gu, Jun Lu, Tao Ma, Xingchang Pan, Zhe Dong, Yong Ma, Yaguang Xu, Yongqing Ma, Zhentao Jin, Liang Chen, Lu Lu, Wenying Liu, Ying Wei, Haixin Zhang, Yan Liu, Kelu Cao, Jing Wang, Guoming Li, Ming Zhou
  • Publication number: 20170164638
    Abstract: Disclosed are a fish protein oligopeptide with low allergenicity and slight fishiness, and industrial preparation method and application thereof The method comprises the following steps: 1) washing fresh fish flesh and/or fish wastes, crushing, and adding water to obtain a mixture; 2) performing thermal denaturation on the mixture to obtain a denaturized protein solution; 3) centrifuging the denaturized protein solution to obtain a precipitate, and adding water into the precipitate and grinding, to obtain a slurry; 4) adjusting the slurry to pH 6-9, and sequentially adding a neutral protease, a papain and an alkaline protease to conduct enzymolysis, and after enzyme inactivation, to obtain an enzymatic hydrolysate; 5) centrifuging the enzymatic hydrolysate, and performing membrane filtration on centrifuged supernatant, to obtain the fish protein oligopeptide with low allergenicity and slight fishiness.
    Type: Application
    Filed: February 24, 2017
    Publication date: June 15, 2017
    Inventors: MUYI CAI, RUIZENG GU, JUN LU, TAO MA, XINGCHANG PAN, ZHE DONG, YONG MA, YAGUANG XU, YONGQING MA, ZHENTAO JIN, LIANG CHEN, LU LU, WENYING LIU, YING WEI, HAIXIN ZHANG, YAN LIU, KELU CAO, JING WANG, GUOMING LI, MING ZHOU
  • Publication number: 20170143001
    Abstract: The present invention provides a soybean oligopeptide with low allergenicity and little bitterness and its preparation method and application. The preparation method includes the following steps: 1) mixing a soybean protein powder with water to obtain a soybean protein solution, and then performing thermal denaturation on the soybean protein solution, to prepare a denatured protein solution; 2) adjusting pH value of the denatured protein solution to 6-9, and then adding a neutral protease and papain to conduct a first enzymolysis, to obtain a first enzymatic hydrolysate; 3) adding an alkaline protease and a flavor protease into the first enzymatic hydrolysate to conduct a second enzymolysis, and after performing enzyme inactivation, to obtain a second enzymatic hydrolysate; and 4) centrifuging the second enzymatic hydrolysate, and performing membrane filtration on centrifuged supernatant liquid, to obtain the soybean oligopeptide with low allergenicity and little bitterness.
    Type: Application
    Filed: February 3, 2017
    Publication date: May 25, 2017
    Inventors: MUYI CAI, RUIZENG GU, JUN LU, TAO MA, XINGCHANG PAN, ZHE DONG, YONG MA, YAGUANG XU, YONGQING MA, ZHENTAO JIN, LIANG CHEN, LU LU, WENYING LIU, YING WEI, HAIXIN ZHANG, YAN LIU, KELU CAO, JING WANG, GUOMING LI, MING ZHOU, HUI CHEN, JIAJI LI
  • Patent number: 7766644
    Abstract: An injection mold including a connecting structure for separating confronting faces of a slide member and a mold base, respectively, during a movement of the slide member. In accordance with several embodiments of the invention, the connecting structure may include a compressible member such that the slide member is biased away from the mold base, and wherein a positive contact between the confronting surfaces is configurable in response to an applied clamping force between the slide member and the mold base. In accordance with an alternative embodiment of the invention a cam arrangement links the slide member and the mold base enabling a positive contact between the confronting surfaces when the slide member is arranged in the in-mold position, and providing a gap between the confronting surfaces during at least a portion of an interval when the slide member is moving.
    Type: Grant
    Filed: March 8, 2007
    Date of Patent: August 3, 2010
    Assignee: Husky Injection Molding Systems Ltd.
    Inventors: Guoming Li, Thomas McGinley
  • Publication number: 20090011070
    Abstract: An injection mold including a connecting structure for separating confronting faces of a slide member and a mold base, respectively, during a movement of the slide member. In accordance with several embodiments of the invention, the connecting structure may include a compressible member such that the slide member is biased away from the mold base, and wherein a positive contact between the confronting surfaces is configurable in response to an applied clamping force between the slide member and the mold base. In accordance with an alternative embodiment of the invention a cam arrangement links the slide member and the mold base enabling a positive contact between the confronting surfaces when the slide member is arranged in the in-mold position, and providing a gap between the confronting surfaces during at least a portion of an interval when the slide member is moving.
    Type: Application
    Filed: March 8, 2007
    Publication date: January 8, 2009
    Inventors: Guoming Li, Thomas McGinley
  • Patent number: 7381049
    Abstract: An injection mold including a connecting structure for separating confronting faces of a slide member and a mold base, respectively, during a movement of the slide member. In accordance with several embodiments of the invention, the connecting structure may include a compressible member such that the slide member is biased away from the mold base, and wherein a positive contact between the confronting surfaces is configurable in response to an applied clamping force between the slide member and the mold base. In accordance with an alternative embodiment of the invention a cam arrangement links the slide member and the mold base enabling a positive contact between the confronting surfaces when the slide member is arranged in the in-mold position, and providing a gap between the confronting surfaces during at least a portion of an interval when the slide member is moving.
    Type: Grant
    Filed: March 8, 2006
    Date of Patent: June 3, 2008
    Assignee: Husky Injection Molding Systems Ltd.
    Inventors: Guoming Li, Thomas McGinley
  • Patent number: 7361009
    Abstract: Disclosed herein is a mold, a molding system and a cooling component. The mold and the molding system use the cooling component. The mold includes a mold cavity plate configured to receive a mold cavity insert. The cooling component includes a jacket configured to define, in combination with the mold cavity insert and the mold cavity plate, a coolant-conveying channel.
    Type: Grant
    Filed: October 20, 2005
    Date of Patent: April 22, 2008
    Assignee: Husky Injection Molding Systems Ltd.
    Inventor: Guoming Li
  • Publication number: 20070212443
    Abstract: An injection mold including a connecting structure for separating confronting faces of a slide member and a mold base, respectively, during a movement of the slide member. In accordance with several embodiments of the invention, the connecting structure may include a compressible member such that the slide member is biased away from the mold base, and wherein a positive contact between the confronting surfaces is configurable in response to an applied clamping force between the slide member and the mold base. In accordance with an alternative embodiment of the invention a cam arrangement links the slide member and the mold base enabling a positive contact between the confronting surfaces when the slide member is arranged in the in-mold position, and providing a gap between the confronting surfaces during at least a portion of an interval when the slide member is moving.
    Type: Application
    Filed: March 8, 2006
    Publication date: September 13, 2007
    Inventors: Guoming Li, Thomas McGinley
  • Patent number: 7234930
    Abstract: A cooling circuit for a neck ring of a preform is conformed to the surface of the neck ring by providing a neck ring in two parts. The first part supports the neck ring and provides strength and durability to the neck ring insert. The second part is formed of porous steel impregnated with highly thermally conductive metal and includes a cooling channel that provides substantially uniform cooling around the neck ring of the preform.
    Type: Grant
    Filed: June 14, 2004
    Date of Patent: June 26, 2007
    Assignee: Husky Injection Molding Systems Ltd.
    Inventors: Joachim Johannes Niewels, Michael K. Zuraw, Guoming Li
  • Publication number: 20070092596
    Abstract: Disclosed herein is a mold, a molding system and a cooling component. The mold and the molding system use the cooling component. The mold includes a mold cavity plate configured to receive a mold cavity insert. The cooling component includes a jacket configured to define, in combination with the mold cavity insert and the mold cavity plate, a coolant-conveying channel.
    Type: Application
    Filed: October 20, 2005
    Publication date: April 26, 2007
    Inventor: Guoming Li
  • Publication number: 20050276879
    Abstract: A cooling circuit for a neck ring of a preform is conformed to the surface of the neck ring by providing a neck ring in two parts. The first part supports the neck ring and provides strength and durability to the neck ring insert. The second part is formed of porous steel impregnated with highly thermally conductive metal and includes a cooling channel that provides substantially uniform cooling around the neck ring of the preform.
    Type: Application
    Filed: June 14, 2004
    Publication date: December 15, 2005
    Inventors: Joachim Johannes Niewels, Michael Zuraw, Guoming Li