Patents by Inventor Guoning Zhang

Guoning Zhang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Hydroxamic acid derivative, method for producing same and use thereof
    Patent number: 11827612
    Abstract: The present disclosure is related to the field of enzyme inhibitors, and in particular to a hydroxamic acid derivative, a method for producing the same and use thereof. The hydroxamic acid group of the hydroxamic acid derivative can be chelated with zinc ions in the LpxC active area, and the derivative has a hydrophobic side chain which can bind to hydrophic channels in the enzyme LpxC. These guarantee that the hydroxamic acid derivative has good bactericidal activity against Gram-negative bacteria and low toxicity. The present disclosure also provides a method for producing the hydroxamic acid derivative, which requires a shorter reaction time and can provide the derivative with a high yield.
    Type: Grant
    Filed: September 16, 2020
    Date of Patent: November 28, 2023
    Assignee: INSTITUTE OF MEDICINAL BIOTECHNOLOGY, CHINESE ACADEMY OF MEDICAL SCIENCES
    Inventors: Yucheng Wang, Xuefu You, Juxian Wang, Xiaonan Du, Minghua Wang, Mei Zhu, Guoning Zhang
  • HYDROXAMIC ACID DERIVATIVE, METHOD FOR PRODUCING SAME AND USE THEREOF
    Publication number: 20220033369
    Abstract: The present disclosure is related to the field of enzyme inhibitors, and in particular to a hydroxamic acid derivative, a method for producing the same and use thereof. The hydroxamic acid group of the hydroxamic acid derivative can be chelated with zinc ions in the LpxC active area, and the derivative has a hydrophobic side chain which can bind to hydrophic channels in the enzyme LpxC. These guarantee that the hydroxamic acid derivative has good bactericidal activity against Gram-negative bacteria and low toxicity. The present disclosure also provides a method for producing the hydroxamic acid derivative, which requires a shorter reaction time and can provide the derivative with a high yield.
    Type: Application
    Filed: September 16, 2020
    Publication date: February 3, 2022
    Inventors: Yucheng Wang, Xuefu You, Juxian Wang, Xiaonan Du, Minghua Wang, Mei Zhu, Guoning Zhang