Abstract: A heavy-load and high-precision transmission mechanism applicable to sheet-metal bending equipment, which includes pressing arms, connecting rods, hinged supports, pressing arm lifting assemblies and pressing arm lifting driving assemblies. The pressing arms are symmetrically arranged on a top part of a rack. A front end part of each pressing arm facing an upper cross beam is hinged with the cross beam through the connecting rod. An intermediate part of each pressing arm or a rear end part of each pressing arm away from the cross beam is hinged on the rack through the hinged support. The rear end part or the intermediate part of each pressing arm is provided with a set of pressing arm lifting assemblies. Each set of pressing arm lifting assemblies is connected with a set of pressing arm lifting driving assemblies. Each set of pressing arm lifting driving assembly includes an all-electric servo motor.

Abstract: A precision compensation mechanism of a full-automatic bidirectional flanging machine comprises an upper die X-direction fine adjustment assembly, an upper die Y-direction fine adjustment assembly, a lower die X-direction fine adjustment assembly and a lower die Y-direction fine adjustment assembly, wherein the fine adjustment assemblies each comprise N adjusting threaded sleeves, N adjusting screws and a threaded sleeve rotation driving device; wherein the N adjusting threaded sleeves are threaded into an upper opening or a lower opening of a C-shaped flanging beam along the length direction of an upper die or a lower die; the outer wall surfaces of the N adjusting threaded sleeves are threaded into the upper opening or the lower opening of the C-shaped flanging beam to form N screw thread pairs I with the thread pitch of P1.

Abstract: A high-precision heavy-load numerically-controlled flanging machine comprises a machine frame, an edge pressing assembly, a flanging beam and a flanging beam transmission mechanism that comprises an inclined slide rail, an inertia block and two crank-connecting rod mechanisms; the flanging beam is provided with a driving inclined plane; the inclined slide rail is mounted on the machine frame; the inertia block is provided with two non-parallel inclined planes, wherein one inclined plane of the inertia block is slidably mounted on the inclined slide rail to form a sliding pair I, and the other inclined plane of the inertia block is in sliding fit with the driving inclined plane of the flanging beam to form a sliding pair II; cranks of the two crank-connecting rod mechanisms are hinged on the machine frame.

Abstract: Provided are a macrolide derivative represented by formula (I), a preparation method thereof, and an application of the macrolide derivative as an inhibitor of one or more protein kinases of TRK, ALK and ROS1,

Abstract: The present invention relates to aromatic ring or heteroaromatic ring derivatives, a preparation method therefor and applications thereof in medicine. Specifically, the present invention relates to aromatic ring or heteroaromatic ring derivatives represented by general formula (I), a preparation method therefor and pharmaceutically acceptable salts thereof, as well as a use thereof as therapeutic agents, especially uses as angiotensin II type 2 receptor (AT2R) antagonists, wherein the definition of each substituent in the general formula (I) is the same as the definition thereof in the description.

Abstract: Provided are a tetrahydroisoquinoline derivative, a preparation method therefor and an application thereof in medicine. In particular, provided are a tetrahydroisoquinoline derivative represented by general formula (I), a preparation method therefor and a pharmaceutically acceptable salt thereof as well as use thereof as a therapeutic agent, in particular as an angiotensin II type 2 receptor (AT2R) antagonist, wherein definitions of substituent groups in the general formula (I) are the same as definitions in the description.

Abstract: A metal workpiece indentation marking device, comprising a frame, a striking head, an automatic marking die, a gripper and a two-dimensional moving mechanism, wherein the top of the striking head is connected to the frame; the striking head can move up and down; the automatic marking die is fixedly disposed at the bottom of the striking head; a clamping jaw for clamping a metal workpiece is disposed at the top of the gripper; the gripper can move back and forth or left and right under the action of the two-dimensional moving mechanism, such that a position to be marked at the top of the metal workpiece can be located under the automatic marking die.

Abstract: A torsion shaft structure based multi-link all-electric servo synchronous bending machine, comprising a machine frame, a lower die fixedly connected to the machine frame and used for bending, a slider capable of moving up and down along the machine frame, and an upper die fixedly connected to the slider and cooperating with the lower die to perform bending, wherein the slider is left-right symmetrically connected to drive mechanisms for driving the slider to realize a transmission ratio adjustable motion.

Abstract: A torsion shaft structure based multi-link all-electric servo synchronous bending machine, comprising a machine frame, a lower die fixedly connected to the machine frame and used for bending, a slider capable of moving up and down along the machine frame, and an upper die fixedly connected to the slider and cooperating with the lower die to perform bending, wherein the slider is left-right symmetrically connected to drive mechanisms for driving the slider to realize a transmission ratio adjustable motion.

Abstract: A high-precision heavy-load numerically-controlled flanging machine comprises a machine frame, an edge pressing assembly, a flanging beam and a flanging beam transmission mechanism that comprises an inclined slide rail, an inertia block and two crank-connecting rod mechanisms; the flanging beam is provided with a driving inclined plane; the inclined slide rail is mounted on the machine frame; the inertia block is provided with two non-parallel inclined planes, wherein one inclined plane of the inertia block is slidably mounted on the inclined slide rail to form a sliding pair I, and the other inclined plane of the inertia block is in sliding fit with the driving inclined plane of the flanging beam to form a sliding pair II; cranks of the two crank-connecting rod mechanisms are hinged on the machine frame.

Abstract: A precision compensation mechanism of a full-automatic bidirectional flanging machine comprises an upper die X-direction fine adjustment assembly, an upper die Y-direction fine adjustment assembly, a lower die X-direction fine adjustment assembly and a lower die Y-direction fine adjustment assembly, wherein the fine adjustment assemblies each comprise N adjusting threaded sleeves, N adjusting screws and a threaded sleeve rotation driving device; wherein the N adjusting threaded sleeves are threaded into an upper opening or a lower opening of a C-shaped flanging beam along the length direction of an upper die or a lower die; the outer wall surfaces of the N adjusting threaded sleeves are threaded into the upper opening or the lower opening of the C-shaped flanging beam to form N screw thread pairs I with the thread pitch of P1.

Abstract: Provided are a tetrahydroisoquinoline derivative, a preparation method therefor and an application thereof in medicine. In particular, provided are a tetrahydroisoquinoline derivative represented by general formula (I), a preparation method therefor and a pharmaceutically acceptable salt thereof as well as use thereof as a therapeutic agent, in particular as an angiotensin II type 2 receptor (AT2R) antagonist, wherein definitions of substituent groups in the general formula (I) are the same as definitions in the description.

Abstract: A metal workpiece indentation marking device, comprising a frame, a striking head, an automatic marking die, a gripper and a two-dimensional moving mechanism, wherein the top of the striking head is connected to the frame; the striking head can move up and down; the automatic marking die is fixedly disposed at the bottom of the striking head; a clamping jaw for clamping a metal workpiece is disposed at the top of the gripper; the gripper can move back and forth or left and right under the action of the two-dimensional moving mechanism, such that a position to be marked at the top of the metal workpiece can be located under the automatic marking die.

Abstract: An integrated molding device suitable for the bending and hemming of a flat sheet, comprising a stand, a worktable, a slider, and a turning beam. The stand comprises a frame structure composed of an upper cross beam, a lower cross beam, and columns on both sides, two ends of the slider are connected to the columns on both sides by means of a pair of sliding pairs A respectively, and the clutching of a bending die is achieved by means of the linear movement of the sliding pairs A; the worktable is fixed on the lower cross beam, and the clutching of a pressing die is achieved by means of the linear movement of the sliding pairs A; two ends of a swing frame are connected to the columns on both sides by means of one connecting block respectively, the connecting block and the columns are connected therebetween by means of a pair of rotating pairs B, and the connecting block and the swing frame are connected therebetween by means of a pair of sliding pairs C.

Abstract: An integrated molding device suitable for the bending and hemming of a flat sheet, comprising a stand, a worktable, a slider, and a turning beam. The stand comprises a frame structure composed of an upper cross beam, a lower cross beam, and columns on both sides, two ends of the slider are connected to the columns on both sides by means of a pair of sliding pairs A respectively, and the clutching of a bending die is achieved by means of the linear movement of the sliding pairs A; the worktable is fixed on the lower cross beam, and the clutching of a pressing die is achieved by means of the linear movement of the sliding pairs A; two ends of a swing frame are connected to the columns on both sides by means of one connecting block respectively, the connecting block and the columns are connected therebetween by means of a pair of rotating pairs B, and the connecting block and the swing frame are connected therebetween by means of a pair of sliding pairs C.

Abstract: Provided is an auxiliary bending robot capable of processing two workpieces simultaneously, including a linear base slide rail, a slider, a movable major arm, a movable minor arm, a front arm, a swing link, and an additional seventh axis. The slider is slidably connected to the linear base slide rail, and a first axis is formed between the slider and the linear base slide rail. A top portion of the slider is directly or indirectly hinged to a rear end of the movable major arm through a second axis, a front end of the movable major arm is hinged to a rear end of the movable minor arm through a third axis, a front end of the movable minor arm is hinged to a rear end of the front arm through a fourth axis, and a front end of the front arm is rotatably connected to a middle portion of the swing link through a fifth axis.

Abstract: Provided is an auxiliary bending robot capable of processing two workpieces simultaneously, including a linear base slide rail, a slider, a movable major arm, a movable minor arm, a front arm, a swing link, and an additional seventh axis. The slider is slidably connected to the linear base slide rail, and a first axis is formed between the slider and the linear base slide rail. A top portion of the slider is directly or indirectly hinged to a rear end of the movable major arm through a second axis, a front end of the movable major arm is hinged to a rear end of the movable minor arm through a third axis, a front end of the movable minor arm is hinged to a rear end of the front arm through a fourth axis, and a front end of the front arm is rotatably connected to a middle portion of the swing link through a fifth axis.