Abstract: The present application provides novel PRMT5 and/or MTA-cooperative PRMT5 inhibiting compounds, or pharmaceutically acceptable salts thereof. The present application also provides pharmaceutical compositions comprising one or more of the compounds, or pharmaceutically acceptable salts thereof as an active ingredient, and the use of the compounds, or pharmaceutically acceptable salts thereof in the treatment of diseases or disorders, including cancers.

Abstract: Disclosed are a series of quinolino-pyrrolidin-2-one compounds, and application thereof in preparation of drugs for ATM inhibitor-related diseases. The present disclosure specifically relates to a derivative compound represented by formula (I), tautomers thereof or pharmaceutically acceptable compositions thereof.

Abstract: Disclosed are a series of quinolino-pyrrolidin-2-one compounds, and application thereof in preparation of drugs for ATM inhibitor-related diseases. The present disclosure specifically relates to a derivative compound represented by formula (I), tautomers thereof or pharmaceutically acceptable compositions thereof.

Abstract: An uncoiling, blanking and forming method includes the steps of: 1) uncoiling a steel coil, wherein a steel strip uncoiled from the steel coil is cleaned and straightened and is fed by a pinch roller to a blanking region; 2) laser blanking, wherein the steel coil enters the blanking region, is cut by a laser cutting head by way of laser blanking to form sheets with a required shape, with waste materials falling down and being conveyed to the outside; 3) outputting the sheets, wherein the sheets pass over a magnetic telescopic belt conveyor, and then carried by means of a manipulator or a robot to a stamping process; 4) stamping forming, wherein the sheets are stamped to form workpieces; and 5) checking, wherein the workpieces are checked and put in storage.

Abstract: An uncoiling, blanking and forming method includes the steps of: 1) uncoiling a steel coil, wherein a steel strip uncoiled from the steel coil is cleaned and straightened and is fed by a pinch roller to a blanking region; 2) laser blanking, wherein the steel coil enters the blanking region, is cut by a laser cutting head by way of laser blanking to form sheets with a required shape, with waste materials falling down and being conveyed to the outside; 3) outputting the sheets, wherein the sheets pass over a magnetic telescopic belt conveyor, and then carried by means of a manipulator or a robot to a stamping process; 4) stamping forming, wherein the sheets are stamped to form workpieces; and 5) checking, wherein the workpieces are checked and put in storage.

Abstract: A wireless billboard system which includes a wireless billboard operative to receive and display text and graphics and to transmit messages wirelessly. A plurality of transmitter/receiver sites are located so as to receive wireless signals transmitted from a transmission site and to transmit them to the wireless billboard and to receive wireless transmissions from each of the wireless billboards and to transmit them to a user. A billboard management site is couplable to each of the transmitter/receiver sites and operative to receive transmissions from the plurality of transmitter/receiver sites and to transmit wirelessly to the transmitter/receiver sites.