Abstract: The present invention discloses compounds of Formula (I), and pharmaceutically acceptable salts and esters thereof: which inhibit the Apoptosis signal-regulating kinase 1 (ASK-1), which is associated with autoimmune disorders, neurodegenerative disorders, inflammatory diseases, chronic kidney disease, cardiovascular disease. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from ASK-1 related disease. The invention also relates to methods of treating an ASK-1 related disease in a subject by administering a pharmaceutical composition comprising the compounds of the present invention. The present invention specifically relates to methods of treating ASK-1 associated with hepatic steatosis, including non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH).

Abstract: Provided are small molecule inhibitors of the KRAS(G12D) mutant oncoprotein having the structural formula: and pharmaceutically acceptable salts and compositions thereof, which are useful for treating cancers and related conditions.

Abstract: A data transmission method, apparatus, and device, and a computer storage medium are provided. The method includes: obtaining an application packet of a target application; transmitting the application packet to a first routing device by using a network data channel, and transmitting, by using the first routing device, the application packet to a proxy server; meanwhile, transmitting the same application packet to a second routing device by using a short-range wireless data channel different from the network data channel, and transmitting, by using the second routing device, the application packet to the proxy server. The proxy server performs, a deduplication mechanism on the application packet and transmit the application packet to an application server corresponding to the target application.

Abstract: The present disclosure provides a display panel having a display area and including: a plurality of infrared emitting units and a plurality of infrared receiving units in the display area. The plurality of infrared emitting units are configured to emit infrared light to outside of the display panel, and the plurality of infrared receiving units are configured to receive the infrared light reflected by an object outside the display panel and output an electrical signal according to the received infrared light.

Abstract: A signal control apparatus and method, a display control apparatus and method, and a display apparatus are provided. The display apparatus includes M rows by N columns of pixel driving circuits arranged in an array, the M pixel driving circuits of each column are grouped into at least a first group of pixel driving circuits and a second group of pixel driving circuits, M and N are integer and N is larger than 2. The first group of pixel driving circuits connect to a first data line to receive a data signal, and the second group of pixel driving circuits connect to a second data line to receive a data signal. The signal control apparatus includes a phase shifting circuit which provides a scanning signal to a pixel driving circuit; and a write control circuit which provides a data signal from a data signal terminal to a pixel driving circuit.

Abstract: Use of a silane additive with carbon-carbon triple bond in an electrolyte for inhibiting the gas production of a cell, use of a combined additive of the silane additive and a film-forming additive in the electrolyte, use of a combined additive of the silane additive and a fluorine-containing lithium salt additive in the electrolyte, an electrolyte and a lithium ion battery containing the silane additive. The combined use of a silane additive and a film-forming additive and the combined use of a silane additive and a fluorine-containing lithium salt additive can not only inhibit the gas production of a cell and improve the high-temperature storage performance of a battery, but also improve the stability of the battery in a high-temperature cycle and a room temperature cycle.

Abstract: Disclosed are a process and continuous system for producing LiPF6, and a prepared mixture crystal, composition, electrolyte solution and lithium ion battery containing LiPF6. During preparation, a first feed stream containing PF5 and a second feed stream containing LiF and HF are introduced into a first microchannel reactor, a gas part of a product in the first microchannel reactor is introduced into a second microchannel reactor to react with a third feed stream containing LiPF6, LiF and HF, and a liquid part of the product in the first microchannel reactor is subjected to crystallization and drying to obtain LiPF6. The LiPF6 has the advantages of a high purity, a uniform particle size, a high product quality stability, etc., and is suitable for use as a component of an electrolyte solution of a lithium ion battery.

Abstract: The disclosure provides a multi-page display screen and a mobile phone including the same. The multi-page display screen includes a first display sub-screen and a second display sub-screen formed by flexible screens. The first display sub-screen and the second display sub-screen each includes a first half screen and a second half screen. The first half screen and the second half screen are pivotable and foldable relative to each other, and the first half screen and the second half screen can be unfolded relative to each other to constitute the first display sub-screen and the second display sub-screen respectively. Backs of the first half screens of the first display sub-screen and in the second display sub-screen are bonded together, such that the first display sub-screen and the second display sub-screen are arranged as book pages. The multi-page display screen makes it easy to switch to a page of a different mode.

Abstract: A pixel circuit and a driving method thereof, and a display device are provided. The pixel circuit includes a data writing circuit, a driving circuit, a first compensation circuit, a second compensation circuit and a light emitting element. The driving circuit includes a control terminal, a first terminal and a second terminal, and is configured to control a driving current which runs through the first terminal and the second terminal and is used to drive the light emitting element to emit light; the data writing circuit is connected with the control terminal of the driving circuit, and is configured to write a data signal or a reference voltage signal to the control terminal of the driving circuit in response to a scan signal.

Abstract: Embodiments of the present disclosure provide a mask assembly and a manufacturing method thereof. The mask assembly includes: a frame; a mask provided with a mask area and connection areas positioned on opposite sides of the mask area; and a plurality of first connection parts in each connection area, wherein the plurality of first connection parts in each connection area are arranged in M rows and N columns, each row includes a plurality of first connection parts, each column includes at least one first connection part, and in the same connection area, the first connection parts of any two adjacent rows are arranged in a staggered manner, where each of M and N is an integer larger than 1, and the mask is fixed to the frame via the plurality of first connection parts.

Abstract: The present disclosure provides a display panel having a display area and including: a plurality of infrared emitting units and a plurality of infrared receiving units in the display area. The plurality of infrared emitting units are configured to emit infrared light to outside of the display panel, and the plurality of infrared receiving units are configured to receive the infrared light reflected by an object outside the display panel and output an electrical signal according to the received infrared light.

Abstract: A display panel and a manufacturing method thereof are disclosed. The display panel includes: a base substrate; a first sub-pixel disposed on the base substrate and including a first light-emitting device configured to emit visible light for display operation; a second a light-emitting device overlapped with the first light-emitting device in a direction perpendicular to the base substrate and configured to emit infrared light; and a first photosensitive device disposed on the base substrate and configured to sense light obtained after the infrared light is reflected.

Abstract: A signal control apparatus and method, a display control apparatus and method, and a display apparatus are provided. The display apparatus includes M rows by N columns of pixel driving circuits arranged in an array, the M pixel driving circuits of each column are grouped into at least a first group of pixel driving circuits and a second group of pixel driving circuits, M and N are integer and N is larger than 2. The first group of pixel driving circuits connect to a first data line to receive a data signal, and the second group of pixel driving circuits connect to a second data line to receive a data signal. The signal control apparatus includes a phase shifting circuit which provides a scanning signal to a pixel driving circuit; and a write control circuit which provides a data signal from a data signal terminal to a pixel driving circuit.

Abstract: A signal control apparatus and method, a display control apparatus and method, and a display apparatus are provided. The display apparatus includes M rows by N columns of pixel driving circuits arranged in an array, the M pixel driving circuits of each column are grouped into at least a first group of pixel driving circuits and a second group of pixel driving circuits, M and N are integer and N is larger than 2. The first group of pixel driving circuits connect to a first data line to receive a data signal, and the second group of pixel driving circuits connect to a second data line to receive a data signal. The signal control apparatus includes a phase shifting circuit which provides a scanning signal to a pixel driving circuit; and a write control circuit which provides a data signal from a data signal terminal to a pixel driving circuit.

Abstract: Disclosed are an alignment mask, a metal mask assembly, and a preparation method therefor. The alignment mask includes a mask body. The mask body includes: multiple alignment holes; and, separating parts surrounding at least some alignment holes and used for separating the areas at where the at least some alignment holes are located from other areas, where the separation parts include at least one semi-etched line.

Abstract: A display apparatus includes a plurality of display panels, a mounting frame, and a central control circuit. The mounting frame includes a side ridge electrically coupled to each of the plurality of display panels. The central control circuit is arranged inside the side ridge. The plurality of display panels are arranged such that a side edge of each of the plurality of display panels is attached to the side ridge to thereby allow the each of the plurality of display panels to be flipped open or close along the side ridge. The central control circuit is electrically coupled to each of the plurality of display panels, and is configured to control a display state of each of the plurality of display panels upon receiving a control signal from a user.

Abstract: A pixel circuit and a driving method thereof, and a display device are provided. The pixel circuit includes a data writing circuit, a driving circuit, a first compensation circuit, a second compensation circuit and a light emitting element. The driving circuit includes a control terminal, a first terminal and a second terminal, and is configured to control a driving current which runs through the first terminal and the second terminal and is used to drive the light emitting element to emit light; the data writing circuit is connected with the control terminal of the driving circuit, and is configured to write a data signal or a reference voltage signal to the control terminal of the driving circuit in response to a scan signal.

Abstract: The disclosure provides a multi-page display screen and a mobile phone including the same. The multi-page display screen includes a first display sub-screen and a second display sub-screen formed by flexible screens. The first display sub-screen and the second display sub-screen each includes a first half screen and a second half screen. The first half screen and the second half screen are pivotable and foldable relative to each other, and the first half screen and the second half screen can be unfolded relative to each other to constitute the first display sub-screen and the second display sub-screen respectively. Backs of the first half screens of the first display sub-screen and in the second display sub-screen are bonded together, such that the first display sub-screen and the second display sub-screen are arranged as book pages. The multi-page display screen makes it easy to switch to a page of a different mode.

Abstract: A display substrate is provided. The display substrate includes a plurality of subpixels configured to emit light for image display; and a plurality of auxiliary subpixels that are not light emitting. The display substrate in a region of the plurality of auxiliary subpixels includes a first auxiliary electrode layer on the base substrate and including a plurality of first auxiliary cathodes respectively in the plurality of auxiliary subpixels; and a second auxiliary electrode layer including a plurality of second auxiliary cathodes respectively in the plurality of auxiliary subpixels, the second auxiliary electrode layer being on a side of the first insulating layer away from the first auxiliary electrode layer. A respective one of the plurality of first auxiliary cathodes and a respective one of the plurality of second auxiliary cathodes are electrically connected to a unitary cathode layer of the plurality of light emitting elements.

Abstract: Disclosed are a federated-learning based method of acquiring model parameters, a system, and a readable storage medium. The method includes: calculating first data of a first terminal and second data of a second terminal to obtain a loss value; and encrypting, by the second terminal, the loss value, and sending, the encrypted loss value to a third terminal; receiving the encrypted loss value sent by the second terminal, by the third terminal, and decrypting the encrypted loss value to obtain the loss value; detecting whether the model to be trained is at convergence according to the loss value after decrypting; in response that the model to be trained is at convergence, acquiring a gradient corresponding to the loss value; and determining a sample parameter corresponding to the gradient, and determining the sample parameter as a model parameter of the model to be trained.