Abstract: The present invention discloses compounds of Formula (I), and pharmaceutically acceptable salts, thereof: which inhibit coronavirus replication activity. The invention further relates to pharmaceutical compositions comprising a compound of Formula (I) or a pharmaceutically acceptable salt thereof, and methods of treating or preventing a coronavirus infection in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of a compound of Formula (I) or a pharmaceutically acceptable salt thereof.

Abstract: The present invention provides compounds of Formula I, pharmaceutical compositions comprising these compounds and methods of using these compounds to prevent or treat FXR-mediated or TGR5-mediated diseases or conditions.

Abstract: The present invention discloses compounds of Formula (I), and pharmaceutically acceptable salts and esters thereof: which inhibit the Apoptosis signal-regulating kinase 1 (ASK-1), which is associated with autoimmune disorders, neurodegenerative disorders, inflammatory diseases, chronic kidney disease, cardiovascular disease. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from ASK-1 related disease. The invention also relates to methods of treating an ASK-1 related disease in a subject by administering a pharmaceutical composition comprising the compounds of the present invention. The present invention specifically relates to methods of treating ASK-1 associated with hepatic steatosis, including non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH).

Abstract: The present invention provides compounds represented by Formula I, or pharmaceutically acceptable salts, stereoisomers, solvates, hydrates or combination thereof, The invention also provides pharmaceutical compositions comprising these compounds and methods of using this compounds for treating FXR-mediated or TGR5-mediated diseases or conditions.

Abstract: A data transmission method, apparatus, and device, and a computer storage medium are provided. The method includes: obtaining an application packet of a target application; transmitting the application packet to a first routing device by using a network data channel, and transmitting, by using the first routing device, the application packet to a proxy server; meanwhile, transmitting the same application packet to a second routing device by using a short-range wireless data channel different from the network data channel, and transmitting, by using the second routing device, the application packet to the proxy server. The proxy server performs, a deduplication mechanism on the application packet and transmit the application packet to an application server corresponding to the target application.

Abstract: The present invention discloses compounds of Formula (I), or pharmaceutically acceptable salts, esters, or prodrugs thereof: which inhibit Respiratory Syncytial Virus (RSV) or HMPV. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from RSV or HMPV infection. The invention also relates to methods of treating an RSV or HMPV infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention.

Abstract: The present invention discloses compounds of Formula (I), and pharmaceutically acceptable salts, thereof: which inhibit coronavirus replication activity. The invention further relates to pharmaceutical compositions comprising a compound of Formula (I) or a pharmaceutically acceptable salt thereof, and methods of treating or preventing a coronavirus infection in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of a compound of Formula (I) or a pharmaceutically acceptable salt thereof.

Abstract: The present invention discloses compounds of Formula (I), and pharmaceutically acceptable salts, thereof: which inhibit coronavirus replication activity. The invention further relates to pharmaceutical compositions comprising a compound of Formula (I) or a pharmaceutically acceptable salt thereof, and methods of treating or preventing a coronavirus infection in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of a compound of Formula (I) or a pharmaceutically acceptable salt thereof.

Abstract: The present disclosure relates to a dual gerotor apparatus. The dual gerotor apparatus comprises a housing configured to provide a first and second hydraulic fluid circuit sharing a single inlet and a single outlet. The dual gerotor apparatus further comprises a gerotor assembly coupling with a rotatable shaft, the gerotor assembly is configured to transfer a hydraulic fluid flowing through the first or second hydraulic fluid circuit from the single inlet to the single outlet. The gerotor comprises a first gerotor pump and a second gerotor pump, the first gerotor pump will be in operation when the rotatable shaft rotates in a first direction, and the second gerotor pump will be in operation when the rotatable shaft rotates in a second direction.

Abstract: A rotary electric machine includes a rotor configured for coupling with a rotary shaft and a stator configured for surrounding the rotor, the stator includes a stator body and stator end windings which extend from axial ends of the stator body. The rotary electric machine further includes a housing configured for receiving the stator and rotor, the housing includes a fluid distributing chamber provided along an inner surface of the housing for being communicated with a plurality of fluid channels so as to distribute the fluid to flow through outer surfaces of the stator body and stator end windings when the stator is inserted into the housing. The present disclosure further relates to a powertrain assembly and an electrified vehicle including the rotary electric machine.

Abstract: A universal automatic test system for a digital plugboard based on imagine processing, includes a digital plugboard test platform, an image acquisition and processing module, a test instrument module and a control and processing module. The universal automatic test system can determine a type of the digital plugboard and a point to be test based on the image of the digital plugboard, and call a corresponding automatic test program to complete the test of each point. A type of the output signal can be obtained through the universal automatic test system. By moving the detection probe, the any position of the digital plugboard can be test, and a fault portion of the digital plugboard can be obtained according to the test result.

Abstract: A method for multi-task-based predicting massive-user loads based on a multi-channel convolutional neural network, and belongs to the technical field of electric power systems. The method includes clustering all residential users into a plurality of clusters with different daily average electricity consumption modes by adopting an agglomerative hierarchical clustering method. Corresponding input data sets are constructed for various clusters by adopting a multi-channel-based multi-source input fusion method. Then, a multi-task-based load prediction model based on a convolutional neural network is established for each of the clusters. Load prediction values for different users in the corresponding cluster are output in parallel by each model to eventually obtain load prediction results of all of the residential users.

Abstract: A universal automatic test system for a digital plugboard based on imagine processing, including a digital plugboard test platform, an image acquisition and processing module, a test instrument module and a control and processing module.

Abstract: Disclosed are an intelligent instrument verification system and method. The intelligent instrument verification system includes an automatic verification system, a reference instrument group and a communication control interface. The automatic verification system is connected to an instrument to be verified through the communication control interface. The automatic verification system is connected to the reference instrument group through the communication control interface. The reference instrument group is connected to the instrument to be verified through the communication control interface.

Abstract: Disclosed are methods of producing human iPSC-derived brain organoids and uses thereof to detect and develop treatment for HCMV-induced brain deformation in developing fetus.

Abstract: The invention claims a flame-retardant and corrosion-resistant fiber bamboo substrate and a preparation method thereof. The preparation method comprises the following steps of: 1) cutting raw bamboo into bamboo filaments; 2) flame-retardant treatment: soaking the bamboo filaments prepared in Step 1) in aqueous solution of a flame retardant; 3) drying: drying the flame-retardant treated bamboo filaments at 55° C. to 65° C. until the absolute water content is not more than 12%; 4) carbonized pyrolysis: feeding the dried bamboo filaments into a carbonized pyrolysis kiln, to be high-temperature treated according to a pyrolysis gradient; and, 5) sequentially gumming, post-gumming drying, pressing, curing, maintaining and splitting to obtain a bamboo substrate. The bamboo substrate has high stability, no cracks on the product surface, enhanced corrosion resistance and excellent flame retardance, and may be used in various climate conditions and environments.

Abstract: A preparation method for a flame-retardant and corrosion-resistant fiber bamboo substrate comprises the following steps of: 1) cutting raw bamboo into bamboo filaments; 2) flame-retardant treatment: soaking the bamboo filaments prepared in Step 1) in aqueous solution of a flame retardant; 3) drying: drying the flame-retardant treated bamboo filaments at 55° C. to 65° C.; 4) carbonized pyrolysis: feeding the dried bamboo filaments into a carbonized pyrolysis kiln; and 5) sequentially gumming, post-gumming drying, pressing, curing, maintaining and splitting to obtain a bamboo substrate.

Abstract: A biochemical reactor involves an online cell examination microscope thereon. The online cell examination microscope comprises a main body, an objective lens, an observation entrance window, a sampling device, an external light source system. Said observation entrance window lies in front of said main body and the sampling device lies in front of said observation entrance window. An objective lens and said external light source system lie behind the observation entrance window in the main body. A reflector prism is installed between the external light source system and the objective lens. A reflector lies behind the objective lens and in front of the observation entrance window. An annular diaphragm is placed in front of the reflecting prism. A CCD or an area image sensor is arranged on the upper side of the reflectance prism.

Abstract: A biochemical reactor involves an online cell examination microscope (4) thereon. Said online cell examination microscope (4) comprises a main body (43), an objective lens (24), an observation entrance window (22), a sampling device (40), an external light source system (60). Said observation entrance window (22) lies in front of said main body (43) and the sampling device (40) lies in front of said observation entrance window (22). An objective lens (24) and said external light source system (60) lie behind the observation entrance window (22) in the main body (43). A reflector prism (25) is installed between the external light source system (60) and the objective lens (24). A reflector (23) lies behind the objective lens (24) and in front of the observation entrance window (22). An annular diaphragm (26) is placed in front of the reflecting prism (25). A CCD or an area image sensor (30) is arranged on the upper side of the reflectance prism (25).