Abstract: The present disclosure relates to the field of pharmacology, and in particular, to a preparation method of high-purity total ginkgo flavonol glycoside. The preparation method of high-purity total ginkgo flavonol glycoside includes: (1) mixing Ginkgo biloba extract powder and a first alkaline solution, subjecting to dissolution and centrifugation to obtain a supernatant; (2) subjecting the supernatant to separation with an acid-polar coupled macroporous resin column and to purification with a polyamide column, to obtain high-purity total ginkgo flavonol glycoside. The purity of the total ginkgo flavonol glycoside prepared by the preparation method of high-purity total ginkgo flavonol glycoside according to the present disclosure is ?90%, and has good clinical application prospects; the preparation process does not require organic reagents such as petroleum ether and ethyl acetate, which is environmentally friendly; the transfer rate of the total flavonol glycoside is high.

Abstract: The present disclosure provides a Ginkgo biloba ketone ester bulk drug. The present disclosure further provides a method for preparing Ginkgo biloba ketone ester bulk drug and use thereof. The present disclosure provides a Ginkgo biloba ketone ester and a preparation method thereof. Through optimized preparation operations and conditions, high-quality Ginkgo biloba ketone ester bulk drug can be obtained. Compared with the Ginkgo biloba ketone ester prepared by traditional methods, the Ginkgo biloba ketone ester of the present disclosure has stable quality, low unqualified rate, and good consistency of different batches of bulk drugs.

Abstract: The present disclosure relates to the field of pharmacy, specifically to a method for preparing a high-purity ginkgolide and a use thereof. The method for preparing total ginkgolide includes the following steps: (1) mixing a Ginkgo biloba extract powder with an alkali solution, obtaining a precipitate by dissolving and centrifuging; (2) obtaining a total ginkgolide concentrate through purifying the precipitate by silica gel column and recrystallizing. The preparation method of total ginkgolide provided in the present disclosure can improve the purity of total ginkgolide, and the purity of the prepared total ginkgolide is ?80%, which has good clinical application prospect; and the preparation process does not require complicated multi-step recrystallization step, and the total ginkgolide yield is high.

Abstract: The present disclosure relates to the field of pharmacology, and in particular, to a preparation method of high-purity total ginkgo flavonol glycoside. The preparation method of high-purity total ginkgo flavonol glycoside includes: (1) mixing Ginkgo biloba extract powder and a first alkaline solution, subjecting to dissolution and centrifugation to obtain a supernatant; (2) subjecting the supernatant to separation with an acid-polar coupled macroporous resin column and to purification with a polyamide column, to obtain high-purity total ginkgo flavonol glycoside. The purity of the total ginkgo flavonol glycoside prepared by the preparation method of high-purity total ginkgo flavonol glycoside according to the present disclosure is ?90%, and has good clinical application prospects; the preparation process does not require organic reagents such as petroleum ether and ethyl acetate, which is environmentally friendly; the transfer rate of the total flavonol glycoside is high.