Abstract: Provided herein are bioactive molecule conjugates, preparation methods and use thereof, particularly bioactive molecule conjugates (such as antibody-drug conjugates and small molecule drug conjugates) obtained by improved coupling of a drug and a targeting moiety, as well as their preparation method and use for the treatment of a disease associated with an abnormal cell activity.

Abstract: A liquid collection process with liquid guiding holes for in-situ leaching an ore body to extract rare earth elements, including: 1) multiple liquid collection channels are provided in an ore body; 2) liquid guiding holes are arranged near the bottom and on both sides of the channels, and these holes and the channels jointly constitute a multi-channel mother liquid drainage and collection control network; 3) a blocking wall is provided in the channels, a front lower part of the wall is connected to a channel outlet by a conduit controlled with a ball valve switch at the outlet; 4) a multi-channel mother liquid collection network of liquid collection engineering control system is finally formed through the alternate operation of pressure release and increase. The process reduces the loss rate of mother liquid, reduces environmental pollution, and improves the recovery rate of rare earth elements.

Abstract: A liquid collection process with secondary channels for in-situ leaching an ore body to extract rare earth elements, including: 1) multiple liquid collection channels are provided in an ore body; 2) secondary channels are provided on both sides of the liquid collection channels, and all of the channels jointly constitute a multi-channel mother liquid drainage and collection control network; 3) a blocking wall is provided in the liquid collection channels, the front lower part of the wall is connected to a channel outlet by a conduit which is controlled with a ball valve switch at the outlet; 4) in the measurement and production, a multi-channel mother liquid collection network of liquid collection engineering control system is finally formed through the alternate operation of pressure release and increase; 5) the rare earth recovery rate is finally improved by adjusting the non-mineral liquid and the loss ratio of the mother liquid.

Abstract: A liquid collection process with liquid guiding holes for in-situ leaching an ore body to extract rare earth elements, including: 1) multiple liquid collection channels are provided in an ore body; 2) liquid guiding holes are arranged near the bottom and on both sides of the channels, and these holes and the channels jointly constitute a multi-channel mother liquid drainage and collection control network; 3) a blocking wall is provided in the channels, a front lower part of the wall is connected to a channel outlet by a conduit controlled with a ball valve switch at the outlet; 4) a multi-channel mother liquid collection network of liquid collection engineering control system is finally formed through the alternate operation of pressure release and increase. The process reduces the loss rate of mother liquid, reduces environmental pollution, and improves the recovery rate of rare earth elements.