Abstract: Disclosed is the use of a combination of an anti-PD-1 antibody and a VEGFR inhibitor in the preparation of a drug for treating cancers.

Abstract: The present disclosure belongs to the technical field of PVC foam co-extruded sheets, and particularly relates to a wide low-temperature impact-resistant and bending-resistant PVC foam co-extruded sheet and a preparation method thereof. The PVC foam co-extruded sheet of the present disclosure includes a core layer and a skin layer. Raw materials of the core layer include PVC resin powder, a silicon-acrylic composite low-temperature toughening and reinforcing agent, a filler, a foaming regulator I, a white foaming agent, a calcium-zinc stabilizer, a cold-resistant plasticizer, stearic acid, polyethylene wax, and oxidized polyethylene wax.

Abstract: An actuating member is provided. The actuating member acts on a valve core rod. A guide surface is arranged on the actuating member. A guide path is formed on the guide surface. The guide surface is configured to slidably abut against a top end of the valve core rod, so that the top end of the valve core rod selectively abuts against a position on the guide path at a different height, so as to adjust a position of the valve core rod in a valve port of a reversing valve, thereby changing a flow area at the valve port.

Abstract: The present invention provides a transmission high-voltage connector for circuit connection of a transmission of a new-energy vehicle, the transmission comprising a box body and a high-voltage connector covering an opening of the box body, the high-voltage connector comprises a housing, at least one reinforcing sheet and a copper bar, and the copper bar is inserted into and connected to the housing; wherein, the housing is an N-sided polygon, and at most N-1 fixing holes are formed in the housing at positions where two side lines are connected; and at positions where two side lines are connected while no fixing hole is formed, the housing embraces and is connected to the reinforcing sheet. The transmission high-voltage connector provided by the present invention is simple in structure, and has enhanced strength and high-temperature deformation resistance.

Abstract: Provided is a method for producing a chlorophenoxycarboxylate, comprising the following steps of: a phenoxycarboxylate under actions of a catalyst A and a catalyst B performing a selective chlorination of a chlorinating agent at a 2-position and/or a 4-position to obtain the chlorophenoxycarboxylate; the catalyst A is a Lewis acid; and the catalyst B has the following structure: R1?—S—R2?. The present disclosure redesigns the process route, and finely screens the catalyst and the chlorinating agent, thereby effectively improving the chlorination selectivity while avoiding the loss of the active ingredient, and the content of the obtained chlorophenoxycarboxylate can reach more than 98.5%, and the yield can reach more than 99%.

Abstract: Disclosed is a preparation method of phenoxycarboxylic acid herbicides. The preparation method comprises the following steps. S1: mixing an anhydrous phenol and a basic substance with a chloro-substituted carboxylic acid ester and performing a one-pot condensation reaction in an anhydrous system to obtain a phenoxycarboxylic acid ester. The chloro-substituted carboxylic acid ester is represented by the formula ClR1COOR, in which R1 is a C1-3 alkanediyl or alkylidene group, R is a C1-10 alkyl group or a C3-10 cycloalkyl group; S2: the phenoxycarboxylic acid ester undergoes selective chlorination with a chlorinating agent in the presence of a first catalyst and a second catalyst to obtain a chloro-substituted phenoxycarboxylic acid ester; and S3: the chloro-substituted phenoxycarboxylic acid ester undergoes an acid hydrolysis reaction to obtain a phenoxycarboxylic acid herbicide represented by formula I, in which R3 is H, Cl or CH3.

Abstract: Disclosed is a preparation method of phenoxycarboxylic acid herbicides. The preparation method comprises the following steps. S1: mixing an anhydrous phenol and a basic substance with a chloro-substituted carboxylic acid ester and performing a one-pot condensation reaction in an anhydrous system to obtain a phenoxycarboxylic acid ester. The chloro-substituted carboxylic acid ester is represented by the formula ClR1COOR, in which R1 is a C1-3 alkanediyl or alkylidene group, R is a C1-10 alkyl group or a C3-10 cycloalkyl group; S2: the phenoxycarboxylic acid ester undergoes selective chlorination with a chlorinating agent in the presence of a first catalyst and a second catalyst to obtain a chloro-substituted phenoxycarboxylic acid ester; and S3: the chloro-substituted phenoxycarboxylic acid ester undergoes an acid hydrolysis reaction to obtain a phenoxycarboxylic acid herbicide represented by formula I, in which R3 is H, Cl or CH3.

Abstract: Provided is a method for producing a chlorophenoxycarboxylate, comprising the following steps of: a phenoxycarboxylate under actions of a catalyst A and a catalyst B performing a selective chlorination of a chlorinating agent at a 2-position and/or a 4-position to obtain the chlorophenoxycarboxylate; the catalyst A is a Lewis acid; and the catalyst B has the following structure: R1?—S—R2?. The present disclosure redesigns the process route, and finely screens the catalyst and the chlorinating agent, thereby effectively improving the chlorination selectivity while avoiding the loss of the active ingredient, and the content of the obtained chlorophenoxycarboxylate can reach more than 98.5%, and the yield can reach more than 99%.

Abstract: The present invention provides a transmission high-voltage connector for circuit connection of a transmission of a new-energy vehicle, the transmission comprising a box body and a high-voltage connector covering an opening of the box body, the high-voltage connector comprises a housing, at least one reinforcing sheet and a copper bar, and the copper bar is inserted into and connected to the housing; wherein, the housing is an N-sided polygon, and at most N-1 fixing holes are formed in the housing at positions where two side lines are connected; and at positions where two side lines are connected while no fixing hole is formed, the housing embraces and is connected to the reinforcing sheet. The transmission high-voltage connector provided by the present invention is simple in structure, and has enhanced strength and high-temperature deformation resistance.

Abstract: The present invention discloses a water-soluble granule formulation of 2,4-D salt, comprising components in the following weight percent: 5-80% 2,4-D salt (calculated as 2,4-D acid), and a water-soluble filler as the balance. The water-soluble granule formulation of 2,4-D salt has an outstanding control efficiency on annual or perennial Poaceae weeds and some broadleaf weeds in fields of soybean and other Fabaceae plants. The formulation is environment-friendly, and has the advantages of being free of organic solvents and dusts and being easy to measure in comparison to conventional emulsifiable formulation, wettable powder formulation and suspension formulation. The present invention also discloses the preparation method of the formulation. The production process is simple, economical and safe. The whole production process, without the use of dangerous chemicals, is easy to control and operate and has a high safety factor.

Abstract: The present invention discloses a water-soluble granule formulation of 2,4-D salt, comprising components in the following weight percent: 5-80% 2,4-D salt (calculated as 2,4-D acid), and a water-soluble filler as the balance. The water-soluble granule formulation of 2,4-D salt has an outstanding control efficiency on annual or perennial Poaceae weeds and some broadleaf weeds in fields of soybean and other Fabaceae plants, for example, such weeds as amaranth, knotweed, lamb's-quarters night shade, siberian cocklebur, barnyard grass, foxtail grass, digitaria sanguinalis, broomcorn millet and the like. The formulation is environment-friendly, and has the advantages of being free of organic solvents and dusts and being easy to measure in comparison to conventional emulsifiable formulation, wettable powder formulation and suspension formulation. The present invention also discloses the preparation method of the formulation. The production process is simple, economical and safe.

Abstract: The present invention discloses a water-soluble granule formulation of 2,4-D salt, comprising components in the following weight percent: 5-80% 2,4-D salt (calculated as 2,4-D acid), and a water-soluble filler as the balance. The water-soluble granule formulation of 2,4-D salt has an outstanding control efficiency on annual or perennial Poaceae weeds and some broadleaf weeds in fields of soybean and other Fabaceae plants, for example, such weeds as amaranth, knotweed, lamb's-quarters night shade, siberian cocklebur, barnyard grass, foxtail grass, digitaria sanguinalis, broomcorn millet and the like. The formulation is environment-friendly, and has the advantages of being free of organic solvents and dusts and being easy to measure in comparison to conventional emulsifiable formulation, wettable powder formulation and suspension formulation. The present invention also discloses the preparation method of the formulation. The production process is simple, economical and safe.

Abstract: The present invention discloses a water-soluble granule formulation of 2,4-D salt, comprising components in the following weight percent: 5-80% 2,4-D salt (calculated as 2,4-D acid), and a water-soluble filler as the balance. The water-soluble granule formulation of 2,4-D salt has an outstanding control efficiency on annual or perennial Poaceae weeds and some broadleaf weeds in fields of soybean and other Fabaceae plants. The formulation is environment-friendly, and has the advantages of being free of organic solvents and dusts and being easy to measure in comparison to conventional emulsifiable formulation, wettable powder formulation and suspension formulation. The present invention also discloses the preparation method of the formulation. The production process is simple, economical and safe. The whole production process, without the use of dangerous chemicals, is easy to control and operate and has a high safety factor.