Patents by Inventor Guoquing Chen

Guoquing Chen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Heterocyclic amino substituted heteroaryl fused pyridines; GABA brain receptor ligands
    Patent number: 6423711
    Abstract: Disclosed are compounds of the formula or the pharmaceutically acceptable non-toxic salts thereof wherein: n is an integer from 0 to 3; the C ring is aryl or heteroaryl; X is CH, N, or O Z represents an electron pair, hydrogen, or (un)substituted heterocycle, aryl, or amido; W is (un)substituted alkyl, aryl, or heteroaryl; A and B are hydrogen or lower alkyl, which compounds are highly selective agonists, antagonists or inverse agonists for GABAa brain receptors or prodrugs of agonists, antagonists or inverse agonists for GABAa brain receptors. These compounds are useful in the diagnosis and treatment of anxiety, Down Syndrome, sleep, cognitive and seizure disorders, and overdose with benzodiazepine drugs and for enhancement of alertness.
    Type: Grant
    Filed: December 13, 2000
    Date of Patent: July 23, 2002
    Assignee: Neurogen Corporation
    Inventors: Guolin Cai, Gang Liu, Guoquing Chen, Pamela A. Albaugh
  • Heterocyclic amino substituted heteroaryl fused pyridines; GABA brain receptor ligands
    Publication number: 20020077474
    Abstract: Disclosed are compounds of the formula 1
    Type: Application
    Filed: December 13, 2000
    Publication date: June 20, 2002
    Applicant: Neurogen
    Inventors: Guolin Cai, Gang Liu, Guoquing Chen, Pamela Albaugh
  • Heterocyclic amino substituted heteroaryl fused pyridines; GABA brain receptor ligands
    Patent number: 6166203
    Abstract: Disclosed are compounds of the formula ##STR1## or the pharmaceutically acceptable non-toxic salts thereof wherein: n is an integer from 0 to 3;the C ring is aryl or heteroaryl;X is CH, N, or OZ represents an electron pair, hydrogen, or (un)substituted heterocycle, aryl, or amido;W is (un)substituted alkyl, aryl, or heteroaryl;A and B are hydrogen or lower alkyl,which compounds are highly selective agonists, antagonists or inverse agonists for GABAa brain receptors or prodrugs of agonists, antagonists or inverse agonists for GABAa brain receptors. These compounds are useful in the diagnosis and treatment of anxiety, Down Syndrome, sleep, cognitive and seizure disorders, and overdose with benzodiazepine drugs and for enhancement of alertness.
    Type: Grant
    Filed: February 26, 1999
    Date of Patent: December 26, 2000
    Assignee: Neurogen Corporation
    Inventors: Guolin Cai, Gang Liu, Guoquing Chen, Pamela A. Albaugh