Abstract: The embodiments of the present disclosure provide a cleaning device, the cleaning device including a body and a floor brush. The floor brush is connected to one end of the device body; the device body is provided with a sewage storage box, and the box body of the sewage storage box is at least for storing and/or filtering garbage suctioned by the floor brush. When the cleaning device is tilted or laid flat for use, no sewage may flow back into the motor from the sewage storage box, which prevents causing the motor to stop or be damaged, and ensures a normal use of the cleaning device.

Abstract: The present disclosure provides a cleaning device. The cleaning device may include a machine body, a cleaning liquid tank, and a floor brush, wherein the floor brush may be connected to an end of the machine body, the cleaning liquid tank may be arranged above the floor brush, and the cleaning liquid tank may be configured to provide cleaning liquid for the floor brush or floor. When a user uses the cleaning device for cleaning work, the user may hold the machine body to control a moving direction of the floor brush. In the cleaning device, by setting a cleaning liquid tank on the floor brush, a volume and weight of the machine body can be reduced, which reduces an overall volume and weight of the cleaning device, thereby reducing a load and weight when the user operates the machine body and improving experience of the user during cleaning work.

Abstract: Provided are a novel bile acid derivative for treating fatty liver disease, a pharmaceutical composition thereof, and a use in the preparation of a medicine for treating and improving diseases and symptoms mediated or caused by FXR or TGR5. The bile acid derivative of the present invention inhibits or delays the metabolism of bile acid by bacterial BSH/7? dehydroxylase in the intestine and greatly prolongs the effective survival time of bile acid in the intestine. The bile acid derivative and the pharmaceutical composition thereof can significantly stimulate bile acid membrane receptor TGR5, promote the secretion of glucagon-like peptide 1 from enteroendocrine cells, reduce liver fat accumulation, significantly improve liver function and increase glucose tolerance, thereby having an excellent effect on the treatment of fatty liver disease.

Abstract: The present invention discloses a quantitative detection method of multiple metabolic components in a biological sample and a metabolic chip used in the method. The detection method includes performing derivatization treatment on the biological sample and then detecting the derivatized biological sample by liquid chromatography-mass spectrometry. During derivatization treatment, 3-nitrophenylhydrazine is used as a derivatization reagent, and 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide is used as a derivatization reaction catalyst. According to the detection method of the present invention, high-sensitivity detection can be achieved, multiple metabolic components of different magnitudes can be detected, the operation is simple and fast, and the method is applicable to clinical detection and scientific research examination.