Abstract: A modified interleukin-2 (IL-2) molecule is obtained by being subjected to a modification as follows: substituting a region in an IL-2 molecule that mediates the binding of the IL-2 molecule to interleukin-2 receptor alpha (IL2R?) with a region in an interleukin-15 (IL-15) molecule that mediates the binding of the IL-15 molecule to interleukin-15 receptor alpha (IL15R?). The region in the IL-15 molecule that mediates the binding of the IL-15 molecule to the IL15R? includes 9 or more amino acid residues. Furthermore, a protein heterodimer including the modified IL-2 molecule and IL15R? (a Sushi domain) or a variant thereof is provided. The modified IL-2 molecule and/or the protein heterodimer including the modified IL-2 significantly reduce(s) an affinity of IL2R? to greatly reduce its side effects in clinical treatment and is promising drug candidate.

Abstract: The present invention provides an anti-TrkA antibody or an antigen-binding fragment thereof, a preparation method, and an application thereof. The present invention also provides an isolated polynucleotide encoding the anti-TrkA antibody or the antigen-binding fragments thereof, and a vector comprising the isolated polynucleotide. The present invention also provides a use of the antibody or the antigen-binding fragment thereof in the preparation of a drug for treating pain.

Abstract: Provided are an anti-NGF antibody or an antigen-binding fragment thereof, a preparation method and an application thereof. Also provided is an isolated polynucleotide encoding the anti-NGF antibody or the antigen-binding fragment thereof, as well as a vector containing the isolated polynucleotide. Also provided is use of the antibody or the antigen-binding fragment thereof of the present invention in preparing the medicament for the treatment of NGF-mediated diseases or disorders.

Abstract: Embodiments of the present invention provide a power supply module and a soft start method. The power supply module includes an input detection circuit configured to output a first notification signal to a trigger drive circuit when it is determined that the power supply module receives a power supply signal; the trigger drive circuit configured to, upon receipt of the first notification signal sent from the input detection circuit, wait for a predetermined duration without sending a drive signal to a current limiting circuit, and to send the driver signal to the current limiting circuit when the predetermined duration elapses; and the current limiting circuit configured to limit a current on a Direct Current (DC) bus of the power supply module when the drive signal is not received by the current limiting circuit, and not to limit the current on the DC bus upon receipt of the drive signal.

Abstract: Embodiments of the present invention provide a power supply module and a soft start method. The power supply module includes an input detection circuit configured to output a first notification signal to a trigger drive circuit when it is determined that the power supply module receives a power supply signal; the trigger drive circuit configured to, upon receipt of the first notification signal sent from the input detection circuit, wait for a predetermined duration without sending a drive signal to a current limiting circuit, and to send the driver signal to the current limiting circuit when the predetermined duration elapses; and the current limiting circuit configured to limit a current on a Direct Current (DC) bus of the power supply module when the drive signal is not received by the current limiting circuit, and not to limit the current on the DC bus upon receipt of the drive signal.