Patents by Inventor Guozheng Liu

Guozheng Liu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Trifunctional and completely clearable specific targeting agents and methods thereof
    Patent number: 10744211
    Abstract: The invention provides a novel trifunctional targeting construct and related compositions and methods that are useful in therapeutic, diagnostic (including imaging) of various biological and/or pathological conditions and diseases such as cancers and diabetes. The trifunctional targeting construct of the invention provides enhanced clearing step and reduced non-specific background via complete clearance of undesired antibody conjugates.
    Type: Grant
    Filed: March 28, 2018
    Date of Patent: August 18, 2020
    Assignee: University of Massachusetts
    Inventors: Guozheng Liu, Shuping Dou
  • TRIFUNCTIONAL AND COMPLETELY CLEARABLE SPECIFIC TARGETING AGENTS AND METHODS THEREOF
    Publication number: 20180250425
    Abstract: The invention provides a novel trifunctional targeting construct and related compositions and methods that are useful in therapeutic, diagnostic (including imaging) of various biological and/or pathological conditions and diseases such as cancers and diabetes. The trifunctional targeting construct of the invention provides enhanced clearing step and reduced non-specific background via complete clearance of undesired antibody conjugates.
    Type: Application
    Filed: March 28, 2018
    Publication date: September 6, 2018
    Inventors: Guozheng Liu, Shuping Dou
  • TRIFUNCTIONAL AND COMPLETELY CLEARABLE SPECIFIC TARGETING AGENTS AND METHODS THEREOF
    Publication number: 20140308205
    Abstract: The invention provides a novel trifunctional targeting construct and related compositions and methods that are useful in therapeutic, diagnostic (including imaging) of various biological and/or pathological conditions and diseases such as cancers and diabetes. The trifunctional targeting construct of the invention provides enhanced clearing step and reduced non-specific background via complete clearance of undesired antibody conjugates.
    Type: Application
    Filed: April 11, 2014
    Publication date: October 16, 2014
    Inventors: Guozheng Liu, Shuping Dou
  • Morpholino imaging and therapy
    Patent number: 6899864
    Abstract: The present invention provides a kit and a method for targeting of a diagnostic or therapeutic agent to a target site in a mammal having a pathological condition. The kit comprises, in separate containers, (a) a first conjugate comprising a targeting moiety and a Morpholino oligomer, wherein the targeting moiety selectively binds to a primary, target-specific binding site of the target site or to a substance produced by or associated with the target site; (b) optionally, a clearing agent; and (c) a second conjugate comprising a complementary Morpholino oligomer and a diagnostic agent or therapeutic agent. The method comprises administering (a), optionally (b), and (c) to a mammal.
    Type: Grant
    Filed: April 1, 2002
    Date of Patent: May 31, 2005
    Assignee: Immunomedics, Inc.
    Inventors: Donald J. Hnatowich, Mary Rusckowski, Guozheng Liu
  • Morpholino imaging and therapy
    Publication number: 20030003102
    Abstract: The present invention provides a kit and a method for targeting of a diagnostic or therapeutic agent to a target site in a mammal having a pathological condition. The kit comprises, in separate containers, (a) a first conjugate comprising a targeting moiety and a Morpholino oligomer, wherein the targeting moiety selectively binds to a primary, target-specific binding site of the target site or to a substance produced by or associated with the target site; (b) optionally, a clearing agent; and (c) a second conjugate comprising a complementary Morpholino oligomer and a diagnostic agent or therapeutic agent. The method comprises administering (a), optionally (b), and (c) to a mammal.
    Type: Application
    Filed: April 1, 2002
    Publication date: January 2, 2003
    Applicant: University of Massachusetts
    Inventors: Donald J. Hnatowich, Mary Rusckowski, Guozheng Liu