Abstract: A macrocyclic TLR7 agonist, a preparation method therefor, a pharmaceutical composition and use thereof. The macrocyclic TLR7 agonist disclosed is as represented by formula I, has good TLR7 agonistic activity, and can be used for treating or preventing tumors or infections caused by viruses.

Abstract: This application sets forth techniques for managing phone number-based user accounts. According to some embodiments, a server computing device can be configured to carry out the steps of (1) receiving, from a first client computing device, a request to create a user account based on a phone number, (2) in response to authenticating that the first client computing device is associated with the phone number: creating the user account based on the phone number, creating a hidden contact address based on the phone number, and assigning the hidden contact address to the user account, and (3) in response to receiving a notification that a second client computing device is associated with the phone number: requiring the user account to be updated to be based on a different phone number, or assigning, to the user account, a visible contact address based on the phone number.

Abstract: A device for removing unwanted objects from cut tobacco in a cut tobacco production line is disclosed, which includes: a raw cut tobacco feeding and conveying unit (N1), a heavy unwanted object removal unit (N2), a cut tobacco dispersion and recovery unit (N3), a moderate unwanted object removal unit (N4), a cut tobacco humidification unit (N5) and a light unwanted object removal unit (N6). An unwanted object removal method using the cut tobacco unwanted object removal device is also disclosed. The device and method of the disclosure can effectively remove unwanted objects from cut tobacco.

Abstract: A back-blowing unblocking device for the dustproof screen of the dryer, a dustproof equipment, and a dryer are provided. The back-blowing unblocking device for the dustproof screen of the dryer utilizes a closed compartment space of the dryer. The back-blowing unblocking device for the dustproof screen of the dryer includes a high-pressure air main pipe, a high-pressure air horizontal pipe, high-pressure air branch pipes, a shunt connecting pipe, and back-blowing fan-shaped nozzles. A length of each high-pressure air branch pipe is equal to a length of an A-shaped dustproof screen. Both ends of the each high-pressure air branch pipe are closed and an upper center opening is welded to the shunt connecting pipe. Both sides of the each high-pressure air branch pipe are densely arranged with the back-blowing fan-shaped nozzles.

Abstract: A back-blowing unblocking device for the dustproof screen of the dryer, a dustproof equipment, and a dryer are provided. The back-blowing unblocking device for the dustproof screen of the dryer utilizes a closed compartment space of the dryer. The back-blowing unblocking device for the dustproof screen of the dryer includes a high-pressure air main pipe, a high-pressure air horizontal pipe, high-pressure air branch pipes, a shunt connecting pipe, and back-blowing fan-shaped nozzles. A length of each high-pressure air branch pipe is equal to a length of an A-shaped dustproof screen. Both ends of the each high-pressure air branch pipe are closed and an upper center opening is welded to the shunt connecting pipe. Both sides of the each high-pressure air branch pipe are densely arranged with the back-blowing fan-shaped nozzles.

Abstract: A recessed plate filter press for circularly pulling and pushing plates includes a main beam, a thrust plate, multiple filter plates, multiple filter plate handles, multiple plate pulling devices, a push plate, a depressing frame, a chain and multiple sprockets, the thrust plate is arranged on the main beam, and the multiple sprockets are arranged at both ends of the main beam, the chain is installed on the multiple sprockets, the multiple filter plate handles are arranged on both sides of the multiple filter plates, the multiple plate pulling devices are arranged apart on the chain, and the depressing frame is arranged on the push plate, and a plate pulling hook of each plate pulling device is snap-connected with each filter plate handle.

Abstract: A filter press includes a frame, a power component and a plurality of filter plates driven by the power component to move to and fro along the frame to be at a pressure filtration position and an unloading position; a vibration cake unloading device includes a driving component and a vibration shaft longitudinally arranged; and protrusions are provided on an outer circumferential wall of the vibration shaft, when the filter plates are located at the unloading position, in the process that the driving component drives the vibration shaft to rotate around its own axis, the protrusions on the vibration shaft collide with the filter plate to assist in unloading. The vibration shaft has a simple structure, which can greatly reduce the cost, and the vibration cake unloading device is flexible in use. A filter press of spiral vibration cake unloading by pulling apart the filter plate twice is further provided.

Abstract: A filter press includes a frame, a power component and a plurality of filter plates driven by the power component to move to and fro along the frame to be at a pressure filtration position and an unloading position; a vibration cake unloading device includes a driving component and a vibration shaft longitudinally arranged; and protrusions are provided on an outer circumferential wall of the vibration shaft, when the filter plates are located at the unloading position, in the process that the driving component drives the vibration shaft to rotate around its own axis, the protrusions on the vibration shaft collide with the filter plate to assist in unloading. The vibration shaft has a simple structure, which can greatly reduce the cost, and the vibration cake unloading device is flexible in use. A filter press of spiral vibration cake unloading by pulling apart the filter plate twice is further provided.