Abstract: Disclosed are a pyrimidine carboxamide compound and an application thereof. Further provided are a pyrimidine carboxamide compound represented by formula (I), or a tautomer, mesomer, racemate, enantiomer, or diastereomer thereof, a mixture form thereof, or a pharmaceutically acceptable salt thereof. The compound can be used as a Vanin enzyme inhibitor, and can be used to prepare a drug for treating various diseases, including Crohn's disease, ulcerative colitis, and so on.

Abstract: A one-pot method is used to prepare a fused pyrazole-type compound substituted at nitrogen on 2-position, specifically an indazole-type compound substituted at nitrogen on 2-position. In the method, after azidizing a halogen in a substrate, without post-processing, R-NH2 can be directly added to proceed a ring-closing reaction with an aldehyde group, so as to give the fused pyrazole-type compound substituted at nitrogen on 2-position. For example, by using 2-fluoro-4 methoxy-5-nitro benzaldehyde as a raw material, the indazole-type compound substituted at nitrogen on 2-position can be obtained via azidation and ring-closing steps, and then a series of indazole derivatives can be produced by means of a hydrogenation reaction and a condensation reaction.

Abstract: A compound represented by formula I are provided. The stereoisomer, racemate, tautomer, isotopic label, prodrug or a pharmaceutically acceptable salt of the compound, and a pharmaceutical composition containing the compound, a preparation method, and medical use of the compound are further provided. The structure is as shown in formula I.

Abstract: The present disclosure relates a compound as an IRAK inhibitor. Specifically, the present disclosure provides a compound of formula I, or a cis-trans isomer, an optical isomer, a racemate, a pharmaceutically acceptable salt, a prodrug, a deuterated derivative thereof, a hydrate or a solvate thereof. The compounds disclosed herein have potent inhibitory effects on IRAK and thus have therapeutic effect on IRAK-related diseases.