Patents by Inventor Gurijala V. Reddy

Gurijala V. Reddy has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for recovery of the desired cis-1,3-oxathiolane nucleosides from their undesired trans-isomers
    Patent number: 6600044
    Abstract: A process for the preparation of 1,3-oxathiolane nucleoside analogues in predominantly the cis-form, from mixture of cis-/trans-1,3-oxathiolane nucleosides or their protected derivatives thereof, comprising: (i) treatment of the cis-/trans-1,3-oxathiolane nucleosides (or protected derivatives thereof) with a pyrimidine base (or it derivatives thereof) and an acid, (ii) adding a suitable acid to the obtained cis-/trans-mixture of isomers, (iii) selective crystallization of the desired cis-isomer salt from a solvent or combination of solvents, and (iv) treatment of the predominantly cis-isomer salt with a suitable base to offer the free 1,3-oxathiolane nucleosides, and thereafter optionally repeating steps (i) to (iv) inclusive.
    Type: Grant
    Filed: June 18, 2001
    Date of Patent: July 29, 2003
    Assignee: Brantford Chemicals Inc.
    Inventors: K. S. Keshava Murthy, Gurijala V. Reddy, Zhi-xian Wang, Chandrawansha B. W. Senanayake
  • Process for recovery of the desired cis-1,3-oxathiolane nucleosides from their undesired trans-isomers
    Publication number: 20030013880
    Abstract: A process for the preparation of 1,3-oxathiolane nucleoside analogues in predominantly the cis-form, from mixture of cis-/trans-1,3-oxathiolane nucleosides or their protected derivatives thereof, comprising:
    Type: Application
    Filed: June 18, 2001
    Publication date: January 16, 2003
    Inventors: K.S. Keshava Murthy, Gurijala V. Reddy, Zhi-xian Wang, Chandrawansha B.W. Senanayake
  • 1,3-oxathiolan-5-ones useful in the production of antiviral nucleoside analogues
    Patent number: 6380388
    Abstract: A compound of the formula A, wherein R* is a chiral auxiliary, and where the configuration at the asymmetric carbon atom between oxygen and sulfur is (R), (S), or combinations of (R) and (S), useful in the preparation of enantiomerically enriched 1,3-oxathiolane nucleoside analogues, for example (−)-FTC and 3TC.
    Type: Grant
    Filed: May 18, 2000
    Date of Patent: April 30, 2002
    Assignee: Brantford Chemicals Inc.
    Inventors: K. S. Keshava Murthy, Stephen E. Horne, Gurijala V. Reddy, Chandrawansha B. W. Senanayake, Bruno K. Radatus