Abstract: Methods and systems for evaluating, mitigating, and managing biosafety and biosecurity risks. The methods and systems establish biosafety and biosecurity risk management procedures and systems, and facilitate auditing of facilities and testing individuals and companies to evaluate compliance with such procedures and systems. Systems and business methods for establishing biosafety and biosecurity risk management procedures and systems, auditing and certifying companies, facilities, systems and individuals for compliance, and analyzing biosafety and biosecurity risks for making investment decisions and for pricing and underwriting such risks in the insurance industry.