Patents by Inventor Gurparlash Singh

Gurparlash Singh has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Transgenic mouse expressing a familial form of human amyloid precursor protein
    Patent number: 6211428
    Abstract: Transgenic non-human mammals which express in their brains a nucleic acid construct comprising a DNA sequence encoding a human amyloid precursor protein FAD variant where at amino acid position 717 valine is substituted by isoleucine. These transgenic non-human mammals can be assays systems for determining compounds which are effective in modulating production of human amyloid precursor protein in brain and in isolated neuronal cells. Specifically exemplified are transgenic mice whose genome comprises a DNA sequence encoding a human amyloid precursor protein FAD variant where at amino acid position 717 valine is substituted by isoleucine operably linked to a Thy-1 promoter. The mice are shown to produce the APP-FAD variant in their brains by mRNA and protein assays.
    Type: Grant
    Filed: April 28, 1997
    Date of Patent: April 3, 2001
    Assignee: Merck & Co., Inc.
    Inventors: Gurparlash Singh, Howard Y. Chen, Robert P. Heavens, Dalip J. S. Sirinathsinghji, David W. Smith, Myrna E. Trumbauer, Leonardus H. T. Van Der Ploeg, Aurawan Vongs, Hui Zheng