Patents by Inventor Guruprasad A. Giridharan
Guruprasad A. Giridharan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Patent number: 12217432Abstract: Assessment of pulmonary function in coronavirus patients includes use of a computer aided diagnostic (CAD) system to assess pulmonary function and risk of mortality in patients with coronavirus disease 2019 (COVID-19). The CAD system processes chest X-ray data from a patient, extracts imaging markers, and grades disease severity based at least in part on the extracted imaging markers, thereby distinguishing between higher risk and lower risk patients.Type: GrantFiled: March 3, 2022Date of Patent: February 4, 2025Assignee: University of Louisville Research Foundation, Inc.Inventors: Ayman S. El-Baz, Ahmed Shalaby, Mohamed Elsharkawy, Ahmed Sharafeldeen, Ahmed Soliman, Ali Mahmoud, Harpal Sandhu, Guruprasad A. Giridharan
-
Publication number: 20240164786Abstract: Instruments and methods are disclosed for left atrial appendage (LAA) closure. An exemplary occluder comprises a lattice framework and an anchor. An exemplary delivery tool provides a catheter-based means of delivery of the occluder to the left atrium and LAA of a heart, such as a human heart, and deployment of the occluder by minimally invasive surgery.Type: ApplicationFiled: March 17, 2022Publication date: May 23, 2024Inventors: Mark SLAUGHTER, Guruprasad GIRIDHARAN, Michael SOBIESKI, Gretel MONREAL, Steven KOENIG, Jorge JIMINEZ, Landon TOMPKINS
-
Publication number: 20230230705Abstract: Assessment of pulmonary function in coronavirus patients includes use of a computer aided diagnostic system to assess pulmonary function and risk of mortality in patents with coronavirus disease 2019. The CAD system processes thoracic X-ray data from a patient, extracts imaging markers, and grades disease severity based at least in part on the extracted imaging markers, thereby distinguishing between higher risk and lower risk patients. An alternative approach is to use an automatic CAD system to grade COVID-19 from computed tomography (CT) images to determine an accurate diagnosis of lung function.Type: ApplicationFiled: March 10, 2023Publication date: July 20, 2023Inventors: Ayman S. El-Baz, Mohamed Elsharkawy, Ahmed Sharafeldeen, Ahmed Shalaby, Ahmed Soliman, Ali Mahmoud, Harpal Sandhu, Guruprasad A. Giridharan
-
Publication number: 20230159871Abstract: An in vitro three-dimensional multicellular system for maintaining tissue such as heart tissue (e.g. human or other animal heart slices) under physiological conditions is provided. Heart tissue that is cultured using the system remains full viable and functional for at least 6 days. The system is thus suitable to continuously monitor the effects of drugs (e.g. cardiotoxicity) during in vitro testing.Type: ApplicationFiled: May 14, 2021Publication date: May 25, 2023Inventors: Guruprasad GIRIDHARAN, Moustafa MEKI, Tamer M.A. MOHAMED
-
Patent number: 11497505Abstract: An atrial appendage closure device is provided that includes an insertion rod having a first end and a second end. An occluding member having an outer surface and an inner surface is connected to the first end of the insertion rod. The occluding member is moveable between a retracted position and a deployed position such that, in the deployed position, the occluding member is configured to provide a seal between a left atrial appendage and a left atrium of a heart. An anchoring member is further connected to the insertion rod and is configured to slide along the insertion rod to secure the device to a wall of a left atrial appendage. Methods for occluding a left atrial appendage that make use of the closure devices are also provided.Type: GrantFiled: December 4, 2019Date of Patent: November 15, 2022Assignee: University of Louisville Research FoundationInventors: Mark S. Slaughter, Guruprasad A. Giridharan, Steven C. Koenig, Michael A. Sobieski, Kevin Soucy
-
Publication number: 20220284586Abstract: Assessment of pulmonary function in coronavirus patients includes use of a computer aided diagnostic system to assess pulmonary function and risk of mortality in patents with coronavirus disease 2019. The CAD system processes thoracic X-ray data from a patient, extracts imaging markers, and grades disease severity based at least in part on the extracted imaging markers, thereby distinguishing between higher risk and lower risk patients.Type: ApplicationFiled: March 3, 2022Publication date: September 8, 2022Inventors: Ayman S. El-Baz, Ahmed Shalaby, Mohamed Elsharkawy, Ahmed Sharafeldeen, Ahmed Soliman, Ali Mahmoud, Harpal Sandhu, Guruprasad A. Giridharan
-
Publication number: 20210345970Abstract: A computer-aided diagnostic (CAD) system and method for non-invasive detection of cancer includes receiving and analyzing data from a plurality of sources, using a neural network to generate an initial classification probability from each data source, assigning weights to the initial classification probabilities, and integrating the initial classification probabilities to generate a final classification. The final classification may be a designation of a tissue, such as a pulmonary nodule, as cancerous or noncancerous.Type: ApplicationFiled: October 14, 2019Publication date: November 11, 2021Inventors: AYMAN S. EL-BAZ, AHMED SOLIMAN, AHMED SHAFFIE, GURUPRASAD A. GIRIDHARAN
-
Patent number: 10898202Abstract: An atrial appendage closure device is provided that includes an occluding portion having a distal surface and a proximal surface opposite the distal surface, the occluding portion being moveable between a retracted position and a deployed position such that, in the deployed position, the occluding portion is configured to provide a seal between a left atrial appendage and a left atrium of a heart. An anchoring portion is operably connected to the occluding member with the anchoring portion being moveable between a retracted position and a deployed position. Methods for occluding a left atrial appendage that make use of the closure devices are also provided.Type: GrantFiled: August 25, 2016Date of Patent: January 26, 2021Assignee: University of Louisville Research Foundation, Inc.Inventors: Mark S. Slaughter, Guruprasad A. Giridharan, Steven C. Koenig, Michael A. Sobieski, Kevin Soucy
-
Publication number: 20200107837Abstract: An atrial appendage closure device is provided that includes an insertion rod having a first end and a second end. An occluding member having an outer surface and an inner surface is connected to the first end of the insertion rod. The occluding member is moveable between a retracted position and a deployed position such that, in the deployed position, the occluding member is configured to provide a seal between a left atrial appendage and a left atrium of a heart. An anchoring member is further connected to the insertion rod and is configured to slide along the insertion rod to secure the device to a wall of a left atrial appendage. Methods for occluding a left atrial appendage that make use of the closure devices are also provided.Type: ApplicationFiled: December 4, 2019Publication date: April 9, 2020Inventors: Mark S. SLAUGHTER, Guruprasad A. GIRIDHARAN, Steven C. KOENIG, Michael A. SOBIESKI, Kevin SOUCY
-
Patent number: 10531878Abstract: An atrial appendage closure device is provided that includes an insertion rod having a first end and a second end. An occluding member having an outer surface and an inner surface is connected to the first end of the insertion rod. The occluding member is moveable between a retracted position and a deployed position such that, in the deployed position, the occluding member is configured to provide a seal between a left atrial appendage and a left atrium of a heart. An anchoring member is further connected to the insertion rod and is configured to slide along the insertion rod to secure the device to a wall of a left atrial appendage. Methods for occluding a left atrial appendage that make use of the closure devices are also provided.Type: GrantFiled: July 26, 2013Date of Patent: January 14, 2020Assignee: University of Louisville Research FoundationInventors: Mark S. Slaughter, Guruprasad A. Giridharan, Steven C. Koenig, Michael A. Sobieski, Kevin Soucy
-
Publication number: 20180235640Abstract: An atrial appendage closure device is provided that includes an occluding portion having a distal surface and a proximal surface opposite the distal surface, the occluding portion being moveable between a retracted position and a deployed position such that, in the deployed position, the occluding portion is configured to provide a seal between a left atrial appendage and a left atrium of a heart. An anchoring portion is operably connected to the occluding member with the anchoring portion being moveable between a retracted position and a deployed position. Methods for occluding a left atrial appendage that make use of the closure devices are also provided.Type: ApplicationFiled: August 25, 2016Publication date: August 23, 2018Inventors: Mark S. SLAUGHTER, Guruprasad A. GIRIDHARAN, Steven C. KOENIG, Michael A. SOBIESKI, Kevin SOUCY
-
Publication number: 20170348017Abstract: Embodiments of this invention relate to endoscopic and laparoscopic surgical instruments. More specifically, embodiments of this invention relate to an open loop polypectomy system including a means for securely closing the loop. In some embodiments, the open loop polypectomy system comprises a snare wire and a capture mechanism wherein, when the snare wire is advanced, the snare wire extends from a distal portion of the open loop polypectomy system along a path passing through the capture mechanism. After the snare wire has advanced through the plane of the capture mechanism, retraction of the capture mechanism secures the snare wire, creating a formed loop around a target tissue. Retraction of at least one of the snare wire and capture mechanism contracts the formed loop, resecting the target tissue.Type: ApplicationFiled: August 22, 2017Publication date: December 7, 2017Applicant: University of Louisville Research Foundation, Inc.Inventors: Gerald W. Dryden, Joseph Watson Vicars, III, Guruprasad A. Giridharan, Lauren Elizabeth Allen, Megan C. Mann, John F. Naber
-
Patent number: 9227002Abstract: Systems and methods for providing cavopulmonary support to a subject are provided that include and make use of a first inflatable extravascular cuff configured to be placed around a superior vena cava in the subject and a second inflatable extravascular cuff configured to be placed around an inferior vena cava in the subject. The system further includes a pump that is operably connected to both the first inflatable extravascular cuff and the second inflatable extravascular cuff, as well as a controller that is in communication with the pump. The controller receives one or more user-defined parameters and, in response to the user-defined parameters, independently controls the inflation and deflation of the first inflatable extravascular cuff and the second inflatable extravascular cuff to provide cavopulmonary support.Type: GrantFiled: June 13, 2014Date of Patent: January 5, 2016Assignee: University of Louisville Research Foundation, Inc.Inventors: Guruprasad A. Giridharan, Steven C. Koenig, Michael A. Sobieski, Palaniappan Sethu, Mark D. Rodefeld
-
Publication number: 20150250482Abstract: An atrial appendage closure device is provided that includes an insertion rod having a first end and a second end. An occluding member having an outer surface and an inner surface is connected to the first end of the insertion rod. The occluding member is moveable between a retracted position and a deployed position such that, in the deployed position, the occluding member is configured to provide a seal between a left atrial appendage and a left atrium of a heart. An anchoring member is further connected to the insertion rod and is configured to slide along the insertion rod to secure the device to a wall of a left atrial appendage. Methods for occluding a left atrial appendage that make use of the closure devices are also provided.Type: ApplicationFiled: July 26, 2013Publication date: September 10, 2015Inventors: Mark S. Slaughter, Guruprasad A. Giridharan, Steven C. Koenig, Michael A. Sobieski, Kevin Soucy
-
Publication number: 20140364866Abstract: Embodiments of this invention relate to endoscopic and laparoscopic surgical instruments. More specifically, embodiments of this invention relate to an open loop snare device including a means for securely closing the loop. In some embodiments, a snare device comprises a snare wire and a capture mechanism wherein, when the snare wire is advanced, the snare wire extends from a distal portion of the device along an arcuate path curving back toward the capture mechanism such that, after the snare wire is advanced, activation of the capture mechanism captures the snare wire, creating a formed loop around a target tissue. Retraction of at least one of the snare wire and capture mechanism contracts the formed loop, resecting the target tissue.Type: ApplicationFiled: January 7, 2013Publication date: December 11, 2014Applicant: UNIVERSITY OF LOUISVILLE RESEARCH FOUNDATION, INC.Inventors: Gerald W. Dryden, Joseph Watson Vicars, III, Guruprasad A. Giridharan, Lauren Elizabeth Allen, Megan C. Mann, John F. Naber
-
Patent number: 8894667Abstract: An endoscopic closure device comprises: a coupling member; a helical needle mounted to the coupling member and carrying a suture; and a plurality of grasping needles, each of said plurality of grasping needles moveable between a storage position and a deployed position. The plurality of grasping needles is configured to be (a) advanced in the storage position into a luminal defect, (b) moved into the deployed position, and (c) then refracted from the luminal defect, thus pulling and drawing tissue surrounding the luminal defect together. Then, upon rotation of the coupling member and the helical needle, the helical needle is driven into and pierces the tissue, carrying the suture through the tissue.Type: GrantFiled: March 9, 2011Date of Patent: November 25, 2014Assignee: University of Louisville Research Foundation, Inc.Inventors: Farid Kehdy, Guruprasad A. Giridharan, Erica J. Wells, Kenny J. King, Lindsay N. Strotman, William R. Ross
-
Patent number: 8231538Abstract: An embodiment of the invention is an in-vivo blood pressure sensor device including a strain transducer and flexible biocompatible material that carries the strain transducer. The flexible biocompatible material is configured to encircle the outside of a blood vessel when surgically installed. A preferred embodiment in-vivo blood pressure sensor device of the invention includes a strain transducer carried by a flexible biocompatible ring that is configured to be surgically installed to encircle a blood vessel. The device also includes passive circuitry encased in biocompatible material for sensing strain in the strain transducer and for providing data to an external reader. The passive circuitry is also configured to be surgically installed in a subject.Type: GrantFiled: February 19, 2008Date of Patent: July 31, 2012Assignee: University of Louisville Research Foundation, Inc.Inventors: Julia W. Aebersold, Guruprasad A. Giridharan, George M. Pantalos, Laman A. Gray, Jr.
-
Publication number: 20120059395Abstract: An endoscopic closure device comprises: a coupling member; a helical needle mounted to the coupling member and carrying a suture; and a plurality of grasping needles, each of said plurality of grasping needles moveable between a storage position and a deployed position. The plurality of grasping needles is configured to be (a) advanced in the storage position into a luminal defect, (b) moved into the deployed position, and (c) then refracted from the luminal defect, thus pulling and drawing tissue surrounding the luminal defect together. Then, upon rotation of the coupling member and the helical needle, the helical needle is driven into and pierces the tissue, carrying the suture through the tissue.Type: ApplicationFiled: March 9, 2011Publication date: March 8, 2012Applicant: UNIVERSITY OF LOUISVILLE RESEARCH FOUNDATION, INC.Inventors: Farid Kehdy, Guruprasad A. Giridharan, Erica J. Wells, Kenny J. King, Lindsay N. Strotman, William R. Ross, II
-
Publication number: 20120034695Abstract: A system for culturing cells and/or tissue includes a tissue/cell culture chamber including a tissue/cell culture membrane, at least one collapsible valve fluidly coupled with the tissue/cell culture chamber, a pump fluidly coupled with the tissue/cell culture chamber, and a flow loop including the pump, chamber, and collapsible valve fluidly coupled together.Type: ApplicationFiled: June 30, 2011Publication date: February 9, 2012Inventors: Palaniappan Sethu, Guruprasad A. Giridharan, Sumanth Prabhu, Rosendo Estrada, Mai-Dung Nguyen
-
Patent number: 7572217Abstract: A system for providing cardiac support to a patient and for promoting myocardial repair and recovery, comprises a device for connecting to a vasculature of the patient and a control module. The device includes a pump, defining a blood-receiving volume, and a cannula, in fluid communication with the blood-receiving volume, for anatomizing to the vasculature of the patient such that the blood-receiving volume may receive blood from and return blood to the vasculature of the patient through the cannula. The control module is for controlling the device and includes a means for establishing user-defined parameters, and a means for operating the pump of the device, which is in communication with the means for establishing user-defined parameters such that the operation of the pump is in response to the established user-defined parameters.Type: GrantFiled: June 15, 2005Date of Patent: August 11, 2009Assignees: University of Louisville Research Foundation, Inc., NDSU Research FoundationInventors: Steven C. Koenig, Guruprasad A. Giridharan, Kenneth N. Litwak, Jacob Glower, Daniel L. Ewert