Patents by Inventor Gurusankar Ramamoorthy

Gurusankar Ramamoorthy has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • PROCESS FOR PREPARING DIPHENYLUREIDO-DIHALOKYNURENIC ACIDS AND TOSYLATE ADDITION SALTS THEREOF
    Publication number: 20220162168
    Abstract: A method of preparing 5,7-dihalo-1,4-dihydro-4-oxoquinoline-2-carboxylic acid tosylate addition salts is provided, which involves direct conversion of esters of Formula V as described herein to acids of Formula VIII as described herein. Tosylate addition salts of Formula IX as described herein are then prepared from the acids of Formula VIII.
    Type: Application
    Filed: February 11, 2022
    Publication date: May 26, 2022
    Inventors: Ananya Sengupta, Sergiy KRASUTSKY, Scott TWEEDIE, Gurusankar RAMAMOORTHY
  • Process for preparing 1,4-dihydro-4-oxoquinoline-2-carboxylates and 4-aminoquinoline compounds therefrom
    Patent number: 10875831
    Abstract: A method for preparing an alkyl 5,7-dihalo-1,4-dihydro-4-oxoquinoline-2-carboxylate ester is described herein. The method comprises cyclizing a compound of Formula III with Eaton's reagent in heated continuous flow reactor to form a compound of Formula IV wherein in Formula III and Formula IV, each X independently is a halogen atom; and each R independently is C1 to C4 alkyl. Optionally, a cosolvent such as dichloromethane can be included with the Eaton's reagent. A method of preparing a diphenylureido-dihalokynurenic acid alkyl ester of Formula VI from the compound of Formula IV also is described.
    Type: Grant
    Filed: August 12, 2019
    Date of Patent: December 29, 2020
    Assignee: Lohocla Research Corporation
    Inventors: Sergiy Krasutsky, Scott Tweedie, Gurusankar Ramamoorthy
  • Substituted-3H-imidazo [4,5-c] pyridine and 1H-pyrrolo[2,3-c]pyridine series of novel ectonucleotide pyrophosphatase/phosphodiesterase-1 (ENPP1) and stimulator for interferon genes (STING) modulators as cancer immunotherapeutics
    Patent number: 10689376
    Abstract: Substituted-3H-imidazo[4,5-c]pyridine and 1H-pyrrolo[2,3-c]pyridine series of novel Ectonucleotide Pyrophosphatase/Phosphodiesterase-1 (ENPP1) and related compounds, which are useful as inhibitors of ENPP1; synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of using the compounds and compositions to treat disorders associated with dysfunction of the ENPP1.
    Type: Grant
    Filed: July 27, 2018
    Date of Patent: June 23, 2020
    Assignees: Stingray Therapeutics, Inc., The University of Utah
    Inventors: Hariprasad Vankayalapati, Xiaohui Liu, Gurusankar Ramamoorthy, Sunil Sharma, Mohan Rao Kaadige, Alexis Weston, Trason Thode
  • Substituted-3H-imidazo[4,5-c]pyridine and 1H-pyrrolo[2,3-c]pyridine series of novel Ectonucleotide Pyrophosphatase/Phosphodiesterase-1 (ENPP1) and Stimulator for Interferon Genes (STING) modulators as cancer immunotherapeutics
    Publication number: 20190031655
    Abstract: Substituted-3H-imidazo[4,5-c]pyridine and 1H-pyrrolo[2,3-c]pyridine series of novel Ectonucleotide Pyrophosphatase/Phosphodiesterase-1 (ENPP1) and related compounds, which are useful as inhibitors of ENPP1; synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of using the compounds and compositions to treat disorders associated with dysfunction of the ENPP1.
    Type: Application
    Filed: July 27, 2018
    Publication date: January 31, 2019
    Inventors: Hariprasad Vankayalapati, Xiaohui Liu, Gurusankar Ramamoorthy, Sunil Sharma, Mohan Rao Kaadige, Alexis Weston, Trason Thode