Abstract: Treatment systems, methods, and apparatuses for treating acne, hyperhidrosis, and other skin conditions are described. Aspects of the technology can include cooling a surface of a patient's skin and detecting changes in the tissue. The tissue can be cooled a sufficient length of time and to a temperature low enough to affect glands or other targeted structures in the skin.

Abstract: Treatment systems, methods, and apparatuses for treating acne, hyperhidrosis, and other skin conditions are described. Aspects of the technology can include cooling a surface of a patient's skin and detecting changes in the tissue. The tissue can be cooled a sufficient length of time and to a temperature low enough to affect glands or other targeted structures in the skin.

Abstract: Treatment systems, methods, and apparatuses for treating acne, hyperhidrosis, and other skin conditions are described. Aspects of the technology can include cooling a surface of a patient's skin and detecting changes in the tissue. The tissue can be cooled a sufficient length of time and to a temperature low enough to affect glands or other targeted structures in the skin.

Abstract: Systems and methods that enable tissue cooling applications and delivery of electrical energy to adipose tissue for alteration and reduction of body fat are described herein. Aspects of the disclosure are directed to, for example, temperature-controlled electroporation of subcutaneous lipid-rich cells. Additional aspects of the disclosure are directed to treatment methods for treating a target region of a human subject's body to achieve an alteration of subcutaneous adipose tissue. The method can include, for example, removing heat from the target region of the human subject during a treatment process to cool subcutaneous lipid-rich cells in the target region to a temperature below normal body temperature. Furthermore, the method can include delivering energy to the target region to produce an electric field in an amount sufficient to create pores in membranes of the subcutaneous lipid-rich cells that have been cooled to the temperature below normal body temperature.

Abstract: Treatment systems, methods, and apparatuses for treating acne, hyperhidrosis, and other skin conditions are described. Aspects of the technology can include cooling a surface of a patient's skin and detecting changes in the tissue. The tissue can be cooled a sufficient length of time and to a temperature low enough to affect glands or other targeted structures in the skin.

Abstract: Systems and methods that enable tissue cooling applications and delivery of electrical energy to adipose tissue for alteration and reduction of body fat are described herein. Aspects of the disclosure are directed to, for example, temperature-controlled electroporation of subcutaneous lipid-rich cells. Additional aspects of the disclosure are directed to treatment methods for treating a target region of a human subject's body to achieve an alteration of subcutaneous adipose tissue. The method can include, for example, removing heat from the target region of the human subject during a treatment process to cool subcutaneous lipid-rich cells in the target region to a temperature below normal body temperature. Furthermore, the method can include delivering energy to the target region to produce an electric field in an amount sufficient to create pores in membranes of the subcutaneous lipid-rich cells that have been cooled to the temperature below normal body temperature.

Abstract: An electroporation method and apparatus generating and applying an electric field according to a user-specified pulsing and temperature profile scheme. The apparatus includes a cuvette holder with a Peltier device forming part of the electrode structures that form part of the holder. Advantageously, one such pulse includes a low voltage pulse of a first duration, immediately followed by a high voltage of a second duration, immediately followed by a low voltage of a third duration. The low voltage electroporation field accumulates molecules at the surface of a cell, the appropriately high voltage field creates an opening in the cell, and the final low voltage field moves the molecule into the cell. The molecules may be DNA, portions of DNA, chemical agents, the receiving cells may be eggs, platelets, human cells, red blood cells, mammalian cells, plant protoplasts, plant pollen, liposomes, bacteria, fungi, yeast, sperm, or other suitable cells.

Abstract: An electroporation method and apparatus generating and applying an electric field according to a user-specified pulsing and temperature profile scheme. The apparatus includes a cuvette holder with a Peltier device forming part of the electrode structures that form part of the holder. Advantageously, one such pulse includes a low voltage pulse of a first duration, immediately followed by a high voltage of a second duration, immediately followed by a low voltage of a third duration. The low voltage electroporation field accumulates molecules at the surface of a cell, the appropriately high voltage field creates an opening in the cell, and the final low voltage field moves the molecule into the cell. The molecules may be DNA, portions of DNA, chemical agents, the receiving cells may be eggs, platelets, human cells, red blood cells, mammalian cells, plant protoplasts, plant pollen, liposomes, bacteria, fungi, yeast, sperm, or other suitable cells.