Abstract: According to an example aspect of the present invention, there is provided a method for the delivery of a session of therapeutic transcranial magnetic stimulation, TMS, the method comprising: defining a session of transcranial magnetic stimulation, TMS, the session of TMS comprising a plurality of pulse trains, each pulse train comprising at least one burst and each burst comprising at least one pulse pair; placing a TMS device relative to an individual's brain such that the TMS device targets a selected region within the brain; and applying the session of TMS using the TMS device, wherein each pulse train comprises 2 to 20 bursts, the interval between bursts being 80 to 500 ms, the interval between pulses of the at least one pulse pair is 1 to 20 ms, and the interval between pulse trains is 1 to 60 seconds.

Abstract: An apparatus and method for facilitating delivery of Transcranial Magnetic Stimulation (TMS) by: receiving anatomical data for a person defining a shape of at least the cranium and an outer surface of the skin surrounding the cranium; receiving information from a tracking system regarding a real-time position and orientation of the head of the person; and controlling a multi-axis robotic arm to maintain a TMS stimulation device at an optimal position and orientation relative to the head based on the anatomical data and the information regarding the real-time position and orientation of the head in order to target a predetermined location within the cranium with the TMS stimulation device; wherein the optimal position and orientation is such that a surface of the TMS stimulation device is a predetermined distance from the outer surface of the skin.

Abstract: It is an aspect of the present invention to provide a method for recording a response to Transcranial Magnetic Stimulation (TMS) utilizing a bi-phasic double pulse pair from a TMS coil device to stimulate a subject wherein the second pulse has a lower amplitude compared to the first pulse in the bi-phasic double pulse pair. Significant advantages are achieved using bi-phasic double pulse pairs, particularly where the second pulse in a pair has an intensity lower than the first. Obtaining measurements is simpler and more accurate as the number and intensity of stimulation can be reduced compared to standard single pulse stimulation.

Abstract: Provided herein is a multichannel Transcranial Magnetic Stimulation (mTMS) coil device with two or more overlapping coil windings within a casing. The mTMS coil device is capable of adjusting parameters of the stimulation of magnetic and induced electric fields through the selective control of the multiple coil windings within the mTMS coil device. Additionally, provided are methods of operation including navigated TMS for adjusting parameters such as location, direction and/or orientation of magnetic and induced electric fields from mTMS coil devices.

Abstract: Described herein are methods including determining a structural effectiveness index (SEI) for a target area of a brain which accounts for the effectiveness of a Transcranial Magnetic Stimulation (TMS) pulse based on at least one neurological feature of the brain. An SEI may include an anisotropy index (AI). An AI may account for the effectiveness of a TMS pulse based at least on the local anisotropy of the target area. An SEI may include a connectivity index (CI). A CI may account for the effectiveness of a TMS pulse at a different location of the brain than a stimulated target area. Moreover, the CI can be based at least partially on white matter tract connections. The SEI of at least one area of a brain may be used in order to plan a minimum effective dose at that location based on the actual neurological structure there, e.g. the anisotropy or white matter tracts at that area.

Abstract: It is an aspect of the present invention to provide a method for recording a response to Transcranial Magnetic Stimulation (TMS) utilizing a bi-phasic double pulse pair from a TMS coil device to stimulate a subject wherein the second pulse has a lower amplitude compared to the first pulse in the bi-phasic double pulse pair. Significant advantages are achieved using bi-phasic double pulse pairs, particularly where the second pulse in a pair has an intensity lower than the first. Obtaining measurements is simpler and more accurate as the number and intensity of stimulation can be reduced compared to standard single pulse stimulation.

Abstract: The present invention relates to the field of mapping cognitive brain functions, more specifically to non-invasive systems for and methods of cognitive mapping. Examples of cognitive brain function which can reliably be mapped according to embodiments of the present invention are speech, language, working-memory and decision-making. According to certain embodiments, navigated Transcranial Magnetic Stimulation (TMS) is utilized along with accurate baseline determination in order to provide accurate, non-invasive cognitive mapping.

Abstract: It is an aspect of the present invention to provide a method for recording a response to Transcranial Magnetic Stimulation (TMS) utilizing a bi-phasic double pulse pair from a TMS coil device to stimulate a subject wherein the second pulse has a lower amplitude compared to the first pulse in the bi-phasic double pulse pair. Significant advantages are achieved using bi-phasic double pulse pairs, particularly where the second pulse in a pair has an intensity lower than the first. Obtaining measurements is simpler and more accurate as the number and intensity of stimulation can be reduced compared to standard single pulse stimulation.

Abstract: According to an example embodiment of the present invention, there is provided an apparatus, comprising a first arm configured to accept a device, the first arm comprising a first counterweight arrangement, a second arm supporting the first arm by a coupling, and a base defining a curve and having the second arm mounted thereon, wherein the second arm is movable along the curve, the base configured to be mounted on a chair. The second arm may be furnished with a second counterweight arrangement.

Abstract: Described herein are methods including determining a structural effectiveness index (SEI) for a target area of a brain which accounts for the effectiveness of a Transcranial Magnetic Stimulation (TMS) pulse based on at least one neurological feature of the brain. An SEI may include an anisotropy index (AI). An AI may account for the effectiveness of a TMS pulse based at least on the local anisotropy of the target area. An SEI may include a connectivity index (CI). A CI may account for the effectiveness of a TMS pulse at a different location of the brain than a stimulated target area. Moreover, the CI can be based at least partially on white matter tract connections. The SEI of at least one area of a brain may be used in order to plan a minimum effective dose at that location based on the actual neurological structure there, e.g. the anisotropy or white matter tracts at that area.

Abstract: According to an example embodiment of the present invention, there is provided an apparatus, comprising a first arm configured to accept a device, the first aim comprising a first counterweight arrangement, a second arm supporting the first arm by a coupling, and a base defining a curve and having the second arm mounted thereon, wherein the second arm is movable along the curve, the base configured to be mounted on a chair. The second arm may be furnished with a second counterweight arrangement.

Abstract: It is an aspect of the present invention to provide a method for recording a response to Transcranial Magnetic Stimulation (TMS) utilizing a bi-phasic double pulse pair from a TMS coil device to stimulate a subject wherein the second pulse has a lower amplitude compared to the first pulse in the bi-phasic double pulse pair. Significant advantages are achieved using bi-phasic double pulse pairs, particularly where the second pulse in a pair has an intensity lower than the first. Obtaining measurements is simpler and more accurate as the number and intensity of stimulation can be reduced compared to standard single pulse stimulation.

Abstract: Provided herein is a multichannel Transcranial Magnetic Stimulation (mTMS) coil device with two or more overlapping coil windings within a casing. The mTMS coil device is capable of adjusting parameters of the stimulation of magnetic and induced electric fields through the selective control of the multiple coil windings within the mTMS coil device. Additionally, provided are methods of operation including navigated TMS for adjusting parameters such as location, direction and/or orientation of magnetic and induced electric fields from mTMS coil devices.

Abstract: The present invention relates to the field of mapping cognitive brain functions, more specifically to non-invasive systems for and methods of cognitive mapping. Examples of cognitive brain function which can reliably be mapped according to embodiments of the present invention are speech, language, working-memory and decision-making. According to certain embodiments, navigated Transcranial Magnetic Stimulation (TMS) is utilized along with accurate baseline determination in order to provide accurate, non-invasive cognitive mapping.

Abstract: A patient breathing system includes a ventilator that provides a driving gas flow to generate patient inspiration. The ventilator further includes a gas inlet for driving gas, the patient breathing system being connectable to a circle which includes an inspiratory hose and an expiratory hose connected to patient, through which circle expired gases can be circulated back to the patient. The circle further includes a fresh gas inlet, an arrangement for enabling the gas flow in a desired direction, a unit for removal of the exhaled carbon dioxide, and a ventilator port for the ventilator connection. The patient breathing system further includes an arrangement by which driving gas of the ventilator has been separated from the patient gases flowing in the circle.

Abstract: A patient breathing system includes a ventilator that provides a driving gas flow to generate patient inspiration. The ventilator further includes a gas inlet for driving gas, the patient breathing system being connectable to a circle which includes an inspiratory hose and an expiratory hose connected to patient, through which circle expired gases can be circulated back to the patient. The circle further includes a fresh gas inlet, an arrangement for enabling the gas flow in a desired direction, a unit for removal of the exhaled carbon dioxide, and a ventilator port for the ventilator connection. The patient breathing system further includes an arrangement by which driving gas of the ventilator has been separated from the patient gases flowing in the circle.

Abstract: A detector for determining the volume and volumetric changes of respiratory gases in a closed circuit anaesthesia circuit having a bellows ventilator. The device includes a first sensor positioned with respect to the bellows for detecting and indicating when the bellows assumes a given expanded position in a bellows housing indicative of the given volume of respiratory gas in the circuit. A second sensor detects and indicates when the bellows assumes an expanded position indicative of the greater amount of expansion than that corresponding to the given expanded position. During respiratory cycles of the patient, indications from the first sensor in the absence of indications from the second sensor indicates that the volume of gas in the closed circuit anaesthesia circuit is not changing, but is remaining at that corresponding to the given expanded position of the bellows.

Abstract: A method of straining a diaphragm and a device therefor. The diaphragm (3) is placed between two preferably ring-shaped frame parts (1, 2). In addition at least between one frame part (1, 2) and the diaphragm (3) is placed a resilient body (4), which touches the frame parts when they are pressed against each other.