Patents by Inventor Gustaf Kylberg
Gustaf Kylberg has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230279324Abstract: The method is for preparing a sample in a microfluidic device. A microfluidic device is provided that has a first reservoir in fluid communication with a second reservoir in fluid communication with and adjacent to a draining unit that has a first absorbing member disposed therein. The first reservoir contains a first liquid that is held in the first reservoir by a capillary stop valve connecting the first and second reservoirs. The second reservoir has a sample support disposed therein. A second liquid, containing substances, is added to the second reservoir. The second liquid contacts the first liquid and the first absorbing member. The first absorbing member absorbs the second liquid and the first liquid. The substances adhere to the sample support.Type: ApplicationFiled: September 9, 2022Publication date: September 7, 2023Inventors: Janosch Hauser, Gustaf Kylberg, Göran Stemme, Ida-Maria Sintorn, Niclas Roxhed
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Patent number: 11484882Abstract: The microfluidic device has a first reservoir that preferably includes a first liquid. The first liquid is being held by a capillary stop valve in the first reservoir. A second reservoir is in fluid communication with the first reservoir. The second reservoir has a second liquid and a sample support disposed therein. The second reservoir has an inlet opening defined therein. A draining unit is adjacent to the second reservoir. The draining unit is in fluid communication with the second reservoir. The draining unit has a first absorption member disposed therein.Type: GrantFiled: September 17, 2020Date of Patent: November 1, 2022Assignee: Intelligent Virus Imaging Inc.Inventors: Janosch Hauser, Gustaf Kylberg, Göran Stemme, Ida-Maria Sintorn, Niclas Roxhed
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Patent number: 11485945Abstract: The method is for preparing a sample in a microfluidic device. A microfluidic device is provided that has a first reservoir in fluid communication with a second reservoir in fluid communication with and adjacent to a draining unit that has a first absorbing member disposed therein. The first reservoir contains a first liquid that is held in the first reservoir by a capillary stop valve connecting the first and second reservoirs. The second reservoir has a sample support disposed therein. A second liquid, containing substances, is added to the second reservoir. The second liquid contacts the first liquid and the first absorbing member. The first absorbing member absorbs the second liquid and the first liquid. The substances adhere to the sample support.Type: GrantFiled: September 18, 2020Date of Patent: November 1, 2022Assignee: Intelligent Virus Imaging IncInventors: Janosch Hauser, Gustaf Kylberg, Göran Stemme, Ida-Maria Sintorn, Niclas Roxhed
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Publication number: 20220080419Abstract: The microfluidic device has a first reservoir that preferably includes a first liquid. The first liquid is being held by a capillary stop valve in the first reservoir. A second reservoir is in fluid communication with the first reservoir. The second reservoir has a second liquid and a sample support disposed therein. The second reservoir has an inlet opening defined therein. A draining unit is adjacent to the second reservoir. The draining unit is in fluid communication with the second reservoir. The draining unit has a first absorption member disposed therein.Type: ApplicationFiled: September 17, 2020Publication date: March 17, 2022Inventors: Janosch Hauser, Gustaf Kylberg, Göran Stemme, Ida-Maria Sintorn, Niclas Roxhed
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Publication number: 20220081662Abstract: The method is for preparing a sample in a microfluidic device. A microfluidic device is provided that has a first reservoir in fluid communication with a second reservoir in fluid communication with and adjacent to a draining unit that has a first absorbing member disposed therein. The first reservoir contains a first liquid that is held in the first reservoir by a capillary stop valve connecting the first and second reservoirs. The second reservoir has a sample support disposed therein. A second liquid, containing substances, is added to the second reservoir. The second liquid contacts the first liquid and the first absorbing member. The first absorbing member absorbs the second liquid and the first liquid. The substances adhere to the sample support.Type: ApplicationFiled: September 18, 2020Publication date: March 17, 2022Inventors: Janosch Hauser, Gustaf Kylberg, Göran Stemme, Ida-Maria Sintorn, Niclas Roxhed
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Patent number: 11002689Abstract: The method is for quantification of purity of sub-visible particle samples. A sample to be analyzed is place in an electron microscope to obtain an electron microscopy image of the sample. The sample contains objects. The objects that have sizes being different from a size range of primary particles and sizes being within the size range of primary particles are enhanced. The objects are detected as being primary particles or debris. The detected primary particles are excluded from the objects so that the objects contain debris but no primary particles. A first total area (T1) of the detected debris is measured. A second total area (T2) of the detected primary particles is measured.Type: GrantFiled: August 23, 2019Date of Patent: May 11, 2021Assignee: INTELLIGENT VIRUS IMAGING INC.Inventors: Ida-Maria Sintorn, Martin Ryner, Gustaf Kylberg, Josefina Nilsson
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Publication number: 20190376910Abstract: The method is for quantification of purity of sub-visible particle samples. A sample to be analyzed is place in an electron microscope to obtain an electron microscopy image of the sample. The sample contains objects. The objects that have sizes being different from a size range of primary particles and sizes being within the size range of primary particles are enhanced. The objects are detected as being primary particles or debris. The detected primary particles are excluded from the objects so that the objects contain debris but no primary particles. A first total area (T1) of the detected debris is measured. A second total area (T2) of the detected primary particles is measured.Type: ApplicationFiled: August 23, 2019Publication date: December 12, 2019Inventors: Ida-Maria Sintorn, Martin Ryner, Gustaf Kylberg, Josefina Nilsson
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Patent number: 10451566Abstract: The method is for quantification of purity of sub-visible particle samples. A sample to be analyzed is place in an electron microscope to obtain an electron microscopy image of the sample. The sample contains objects. The objects that have sizes being different from a size range of primary particles and sizes being within the size range of primary particles are enhanced. The objects are detected as being primary particles or debris. The detected primary particles are excluded from the objects so that the objects contain debris but no primary particles. A first total area (T1) of the detected debris is measured. A second total area (T2) of the detected primary particles is measured.Type: GrantFiled: September 11, 2017Date of Patent: October 22, 2019Assignee: Intelligent Virus Imaging Inc.Inventors: Ida-Maria Sintorn, Martin Ryner, Gustaf Kylberg, Josefina Nilsson
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Publication number: 20190011378Abstract: The method is for quantification of purity of sub-visible particle samples. A sample to be analyzed is place in an electron microscope to obtain an electron microscopy image of the sample. The sample contains objects. The objects that have sizes being different from a size range of primary particles and sizes being within the size range of primary particles are enhanced. The objects are detected as being primary particles or debris. The detected primary particles are excluded from the objects so that the objects contain debris but no primary particles. A first total area (T1) of the detected debris is measured. A second total area (T2) of the detected primary particles is measured.Type: ApplicationFiled: September 11, 2017Publication date: January 10, 2019Applicant: Intelligent Virus Imaging Inc.Inventors: Ida-Maria Sintorn, Martin Ryner, Gustaf Kylberg, Josefina Nilsson
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Patent number: 9928989Abstract: The method is for automatic astigmatism correction of a lens system. A first image of a first frequency spectrum in a microscope is provided. The first image of a view is not in focus. The first image is then imaged. A first roundness measure of a distribution and directions of intensities in the first image is determined. The lens is changed to a second stigmator setting to provide a second image of a second frequency spectrum. The second image of the view is not in focus. The second image is the same view as the first image of the view at the first stigmator setting. A second roundness measure of a distribution and directions of intensities in the second image is determined. The first roundness measure is compared with the second roundness measure. The image with the roundness measure indicating the roundest distribution is selected.Type: GrantFiled: June 13, 2017Date of Patent: March 27, 2018Assignee: INTELLIGENT VIRUS IMAGING INC.Inventors: Ida-Maria Sintorn, Rickard Nordstrom, Gustaf Kylberg
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Publication number: 20170287676Abstract: The method is for automatic astigmatism correction of a lens system. A first image of a first frequency spectrum in a microscope is provided. The first image of a view is not in focus. The first image is then imaged. A first roundness measure of a distribution and directions of intensities in the first image is determined. The lens is changed to a second stigmator setting to provide a second image of a second frequency spectrum. The second image of the view is not in focus. The second image is the same view as the first image of the view at the first stigmator setting. A second roundness measure of a distribution and directions of intensities in the second image is determined. The first roundness measure is compared with the second roundness measure. The image with the roundness measure indicating the roundest distribution is selected.Type: ApplicationFiled: June 13, 2017Publication date: October 5, 2017Inventors: Ida-Maria Sintorn, Rickard Nordstrom Nordstrom, Gustaf Kylberg
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Patent number: 9711323Abstract: The method is for automatic astigmatism correction of a lens system. A first image is provided that is not in focus at a first stigmator setting of a set of lenses. A calculating device calculates a corresponding first Fourier spectrum image. A distribution and direction of pixels of the Fourier spectrum image are determined by calculating a first vector and a second vector. The first vector is compared with the second vector. The lens system is changed from a first stigmator setting to a second stigmator setting to provide a second image. A corresponding Fourier spectrum image is calculated. The distribution and direction of pixels of the second Fourier spectrum image is determined by calculating a third vector and a fourth vector. The third vector is compared to the fourth vector. The image that has the lowest vector ratio is selected.Type: GrantFiled: June 17, 2015Date of Patent: July 18, 2017Assignee: Intelligent Virus Imaging Inc.Inventors: Ida-Maria Sintorn, Rickard Nordstrom Nordstrom, Gustaf Kylberg
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Publication number: 20170018396Abstract: The method is for automatic astigmatism correction of a lens system. A first image is provided that is not in focus at a first stigmator setting of a set of lenses. A calculating device calculates a corresponding first Fourier spectrum image. A distribution and direction of pixels of the Fourier spectrum image are determined by calculating a first vector and a second vector. The first vector is compared with the second vector. The lens system is changed from a first stigmator setting to a second stigmator setting to provide a second image. A corresponding Fourier spectrum image is calculated. The distribution and direction of pixels of the second Fourier spectrum image is determined by calculating a third vector and a fourth vector. The third vector is compared to the fourth vector. The image that has the lowest vector ratio is selected.Type: ApplicationFiled: June 17, 2015Publication date: January 19, 2017Inventors: Ida-Maria Sintorn, Rickard Nordstrom Nordstrom, Gustaf Kylberg