Patents by Inventor Gustavo Alejandro Stolovitzky
Gustavo Alejandro Stolovitzky has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11931225Abstract: One or more embodiments include antimicrobial bandages with nanostructures, formation thereof, and usage thereof to facilitate wound healing. In one embodiment, a bandage apparatus that facilitates healing a wound is provided. The bandage apparatus includes a substrate having an attachment mechanism that facilitates removably attaching the substrate to a part of a body having the wound. The bandage apparatus also includes a nanostructure film provided on a surface of the substrate and configured to contact the wound when the substrate is attached to the part of the body having the wound, wherein the nanostructure film includes a plurality of nanostructures.Type: GrantFiled: December 23, 2020Date of Patent: March 19, 2024Assignee: INTERNATIONAL BUSINESS MACHINES CORPORATIONInventors: Huan Hu, Minhua Lu, Vince Siu, Gustavo Alejandro Stolovitzky
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Publication number: 20230313192Abstract: Techniques for positional delivery and position encoding by oligonucleotides of biological cells for single cell RNA sequencing are provided. In one aspect, a method of positional delivery and encoding of cells in a biological sample includes: encoding the cells in the biological sample for single cell sequencing by delivering molecular probes inside the cells that encode a position of the cells in the biological sample. A system for positional delivery and encoding of cells in a biological sample is also provided.Type: ApplicationFiled: June 8, 2023Publication date: October 5, 2023Inventors: Pablo Meyer Rojas, Gustavo Alejandro Stolovitzky
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Patent number: 11766484Abstract: Techniques regarding the transportation and/or delivery of molecular cargo by exosomes are provided. For example, one or more embodiments described herein can comprise a molecule, which can comprise a chemically modified molecular cargo bonded to a surface biomolecule of an exosome. The surface biomolecule can be located on a bilayer membrane of the exosome opposite a cytoplasm of the exosome.Type: GrantFiled: January 3, 2019Date of Patent: September 26, 2023Assignee: INTERNATIONAL BUSINESS MACHINES CORPORATIONInventors: Navneet Dogra, Gustavo Alejandro Stolovitzky
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Patent number: 11739327Abstract: Techniques for positional delivery and position encoding by oligonucleotides of biological cells for single cell RNA sequencing are provided. In one aspect, a method of positional delivery and encoding of cells in a biological sample includes: encoding the cells in the biological sample for single cell sequencing by delivering molecular probes inside the cells that encode a position of the cells in the biological sample. A system for positional delivery and encoding of cells in a biological sample is also provided.Type: GrantFiled: April 11, 2020Date of Patent: August 29, 2023Assignee: International Business Machines CorporationInventors: Pablo Meyer Rojas, Gustavo Alejandro Stolovitzky
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Publication number: 20230259811Abstract: There are provided a system, a method and computer program product providing a data-to-model challenge platform for enabling bidders publicly build, test, evaluate, validate and optimize AI models on proprietary data while at the same time avoiding the need to grant them access to the data itself. Rather, the bidder develops analytics on the enterprise’s data to solve a task desirable to the organization and submits the analytics for evaluation against other bidders. The offering organization evaluates all submissions from the bidders and rank submissions against each other using the same metrics, wherein the metrics for selecting the winning bidder can include response time, number and rate of attempts to solve the analytics, quality of results, code compactness, team size etc. Allowing the submissions of the bidders to be visible only to the offering organization can occur subject to an agreement that the offering organization and the bidder sign.Type: ApplicationFiled: February 14, 2022Publication date: August 17, 2023Inventors: Mahtab Mirmomeni, John Maxwell Cohn, Gustavo Alejandro Stolovitzky, Stefan Harrer
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Patent number: 11208648Abstract: Techniques regarding measuring a position and transcriptome of one or more cells from a biological sample are provided. For example, one or more embodiments described herein can comprise a method, which can comprise covalently bonding a probe to a molecular structure located on a cell to label the cell according to a position of the cell with regards to a biological sample comprising the cell. The probe comprises an oligonucleotide sequence that can be indicative of the position.Type: GrantFiled: November 16, 2018Date of Patent: December 28, 2021Assignee: INTERNATIONAL BUSINESS MACHINES CORPORATIONInventors: Robert Vogel, Navneet Dogra, Lena Voith von Voithenberg, Aditya Kashyap, Govind V. Kaigala, Gustavo Alejandro Stolovitzky
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Publication number: 20210317449Abstract: Techniques for positional delivery and position encoding by oligonucleotides of biological cells for single cell RNA sequencing are provided. In one aspect, a method of positional delivery and encoding of cells in a biological sample includes: encoding the cells in the biological sample for single cell sequencing by delivering molecular probes inside the cells that encode a position of the cells in the biological sample. A system for positional delivery and encoding of cells in a biological sample is also provided.Type: ApplicationFiled: April 11, 2020Publication date: October 14, 2021Inventors: Pablo Meyer Rojas, Gustavo Alejandro Stolovitzky
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Publication number: 20210145647Abstract: The subject disclosure is directed to antimicrobial bandages with nanostructures, formation thereof, and usage thereof to facilitate wound healing. In one embodiment, a bandage apparatus that facilitates healing a wound is provided. The bandage apparatus comprises a substrate comprising an attachment mechanism that facilitates removably attaching the substrate to a part of a body comprising the wound. The bandage apparatus further comprises a nanostructure film provided on a surface of the substrate and configured to contact the wound when the substrate is attached to the part of the body comprising the wound, wherein the nanostructure film comprises a plurality of nanostructures.Type: ApplicationFiled: December 23, 2020Publication date: May 20, 2021Inventors: Huan Hu, Minhua Lu, Vince Siu, Gustavo Alejandro Stolovitzky
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Patent number: 10952904Abstract: Bandage apparatus, methods, and antimicrobial bandages for facilitating wound healing by providing an antimicrobial functionality. A bandage apparatus includes a substrate with a first surface and a second surface opposing the first surface. An attachment mechanism and a nanostructure film are provided on the first surface. The attachment mechanism facilitates removably attaching the substrate to a part of a body comprising a wound. The nanostructure film includes a plurality of nanostructures that contact the wound without puncturing the wound when the substrate is attached to the part of the body comprising the wound.Type: GrantFiled: November 28, 2017Date of Patent: March 23, 2021Assignee: INTERNATIONAL BUSINESS MACHINES CORPORATIONInventors: Huan Hu, Minhua Lu, Vince Siu, Gustavo Alejandro Stolovitzky
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Publication number: 20200215201Abstract: Techniques regarding the transportation and/or delivery of molecular cargo by exosomes are provided. For example, one or more embodiments described herein can comprise a molecule, which can comprise a chemically modified molecular cargo bonded to a surface biomolecule of an exosome. The surface biomolecule can be located on a bilayer membrane of the exosome opposite a cytoplasm of the exosome.Type: ApplicationFiled: January 3, 2019Publication date: July 9, 2020Inventors: Navneet Dogra, Gustavo Alejandro Stolovitzky
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Publication number: 20200157528Abstract: Techniques regarding measuring a position and transcriptome of one or more cells from a biological sample are provided. For example, one or more embodiments described herein can comprise a method, which can comprise covalently bonding a probe to a molecular structure located on a cell to label the cell according to a position of the cell with regards to a biological sample comprising the cell. The probe comprises an oligonucleotide sequence that can be indicative of the position.Type: ApplicationFiled: November 16, 2018Publication date: May 21, 2020Inventors: Robert Vogel, Navneet Dogra, Lena Voith von Voithenberg, Aditya Kashyap, Govind V. Kaigala, Gustavo Alejandro Stolovitzky
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Publication number: 20190159937Abstract: The subject disclosure is directed to antimicrobial bandages with nanostructures, formation thereof, and usage thereof to facilitate wound healing. In one embodiment, a bandage apparatus that facilitates healing a wound is provided. The bandage apparatus comprises a substrate comprising an attachment mechanism that facilitates removably attaching the substrate to a part of a body comprising the wound. The bandage apparatus further comprises a nanostructure film provided on a surface of the substrate and configured to contact the wound when the substrate is attached to the part of the body comprising the wound, wherein the nanostructure film comprises a plurality of nanostructures.Type: ApplicationFiled: November 28, 2017Publication date: May 30, 2019Inventors: Huan Hu, Minhua Lu, Vince Siu, Gustavo Alejandro Stolovitzky
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Patent number: 8618581Abstract: A field effect transistor device includes: a reservoir bifurcated by a membrane of three layers: two electrically insulating layers; and an electrically conductive gate between the two insulating layers. The gate has a surface charge polarity different from at least one of the insulating layers. A nanochannel runs through the membrane, connecting both parts of the reservoir. The device further includes: an ionic solution filling the reservoir and the nanochannel; a drain electrode; a source electrode; and voltages applied to the electrodes (a voltage between the source and drain electrodes and a voltage on the gate) for turning on an ionic current through the ionic channel wherein the voltage on the gate gates the transportation of ions through the ionic channel.Type: GrantFiled: February 3, 2012Date of Patent: December 31, 2013Assignee: International Business Machines CorporationInventors: Hongbo Peng, Stanislav Polonsky, Stephen M. Rossnagel, Gustavo Alejandro Stolovitzky
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Patent number: 8271414Abstract: Methods, systems and apparatus for characterizing networks are presented. For example, a method of characterizing a network represented by a plurality of nodes and a plurality of edges is provided. The method may be implemented on a processor device and includes calculating, for example, by the processor device, a passthrough count of at least a portion of the network. The passthrough count includes a count of a number of passthroughs in the at least a portion of the network. A passthrough includes one of the plurality of nodes, a directed edge of the plurality of edges coupled to the one of the plurality of nodes, and another edge of the plurality of edges coupled to the one of the plurality of nodes. At most one of the directed edge and the other edge is directed towards the one of the plurality of nodes. At most one of the directed edge and the other edge is directed away from the one of the plurality of nodes.Type: GrantFiled: July 24, 2009Date of Patent: September 18, 2012Assignees: International Business Machines Corporation, Mount Sinai School of Medicine of New York UniversityInventors: Guillermo Alberto Cecchi, Srinivas Ravi Viraraghava Iyengar, Avi Ma'ayan, Ravishankar Rao, Gustavo Alejandro Stolovitzky, John Michael Wagner
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Patent number: 8200982Abstract: A method of processing semiotic data includes receiving semiotic data including at least one data set P, selecting a function h, and for at least one of each data set P to be collected, computing h(P), destroying data set P, and storing h(P) in a database, wherein data set P cannot be extracted from h(P). The method further includes selecting a private key/public key (K, k) once for all cases, one of destroying the private key K and sending the private key K to a trusted party, and choosing function h as the public encryption function corresponding to k.Type: GrantFiled: March 19, 2010Date of Patent: June 12, 2012Assignee: International Business Machines CorporationInventors: Andrea Califano, Stephen Carl Kaufman, Marco Martens, William Robert Pulleyblank, Gustavo Alejandro Stolovitzky, Charles Philippe Tresser, Chai Wah Wu
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Publication number: 20120132886Abstract: A field effect transistor device includes: a reservoir bifurcated by a membrane of three layers: two electrically insulating layers; and an electrically conductive gate between the two insulating layers. The gate has a surface charge polarity different from at least one of the insulating layers. A nanochannel runs through the membrane, connecting both parts of the reservoir. The device further includes: an ionic solution filling the reservoir and the nanochannel; a drain electrode; a source electrode; and voltages applied to the electrodes (a voltage between the source and drain electrodes and a voltage on the gate) for turning on an ionic current through the ionic channel wherein the voltage on the gate gates the transportation of ions through the ionic channel.Type: ApplicationFiled: February 3, 2012Publication date: May 31, 2012Applicant: INTERNATIONAL BUSINESS MACHINES CORPORATIONInventors: Hongbo Peng, Stanislav Polonsky, Stephen Rossnagel, Gustavo Alejandro Stolovitzky
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Patent number: 8110410Abstract: A field effect transistor device includes: a reservoir bifurcated by a membrane of three layers: two electrically insulating layers; and an electrically conductive gate between the two insulating layers. The gate has a surface charge polarity different from at least one of the insulating layers. A nanochannel runs through the membrane, connecting both parts of the reservoir. The device further includes: an ionic solution filling the reservoir and the nanochannel; a drain electrode; a source electrode; and voltages applied to the electrodes (a voltage between the source and drain electrodes and a voltage on the gate) for turning on an ionic current through the ionic channel wherein the voltage on the gate gates the transportation of ions through the ionic channel.Type: GrantFiled: June 29, 2009Date of Patent: February 7, 2012Assignee: International Business Machines CorporationInventors: Hongbo Peng, Stanislav Polonsky, Stephen M. Rossnagel, Gustavo Alejandro Stolovitzky
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Publication number: 20110022355Abstract: Methods, systems and apparatus for characterizing networks are presented. For example, a method of characterizing a network represented by a plurality of nodes and a plurality of edges is provided. The method may be implemented on a processor device and includes calculating, for example, by the processor device, a passthrough count of at least a portion of the network. The passthrough count includes a count of a number of passthroughs in the at least a portion of the network. A passthrough includes one of the plurality of nodes, a directed edge of the plurality of edges coupled to the one of the plurality of nodes, and another edge of the plurality of edges coupled to the one of the plurality of nodes. At most one of the directed edge and the other edge is directed towards the one of the plurality of nodes. At most one of the directed edge and the other edge is directed away from the one of the plurality of nodes.Type: ApplicationFiled: July 24, 2009Publication date: January 27, 2011Applicants: International Business Machines Corporation, Mount Sinai School of Medicine of New York UniversityInventors: Guillermo Alberto Cecchi, Srinivas Ravi Viraraghava Iyengar, Avi Ma'ayan, Ravishankar Rao, Gustavo Alejandro Stolovitzky, John Michael Wagner
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Publication number: 20100327255Abstract: A field effect transistor device includes: a reservoir bifurcated by a membrane of three layers: two electrically insulating layers; and an electrically conductive gate between the two insulating layers. The gate has a surface charge polarity different from at least one of the insulating layers. A nanochannel runs through the membrane, connecting both parts of the reservoir. The device further includes: an ionic solution filling the reservoir and the nanochannel; a drain electrode; a source electrode; and voltages applied to the electrodes (a voltage between the source and drain electrodes and a voltage on the gate) for turning on an ionic current through the ionic channel wherein the voltage on the gate gates the transportation of ions through the ionic channel.Type: ApplicationFiled: June 29, 2009Publication date: December 30, 2010Applicant: INTERNATIONAL BUSINESS MACHINES CORPORATIONInventors: Hongbo Peng, Stanislav Polonsky, Stephen Rossnagel, Gustavo Alejandro Stolovitzky
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Patent number: 7761715Abstract: A method (as well as system and signal-bearing medium) of processing biometric data, includes receiving biometric data including a data set P, selecting a secure hash function h, and for each data set P to be collected, computing h(P), destroying the data set P, and storing h(P) in a database, wherein data set P cannot be extracted from h(P).Type: GrantFiled: December 10, 1999Date of Patent: July 20, 2010Assignee: International Business Machines CorporationInventors: Andrea Califano, Stephen Carl Kaufman, Marco Martens, William Robert Pulleyblank, Gustavo Alejandro Stolovitzky, Charles Philippe Tresser, Chai Wah Wu