Abstract: In one or more embodiments the present invention provides a three layer bimodal amphiphilic co-network (?-APCN) based drug delivery device and methods for its making and use. In various embodiments, the system is based on a three-layer scheme. A center layer is composed of a ?-APCN matrix containing a high drug loading and exhibiting high drug diffusivity and two outer layers which are also ?-APCN-based, contain no-drug and are instead loaded with a diffusional barrier such as vitamin E, which considerably slows drug diffusion through these outer layers. Both modeling and experimental data demonstrates that the combined effect of non-uniform distribution of drug loading and diffusion constants within the three-layer systems of various embodiments of the present invention is capable of maintaining a low local drug concentration at the polymer-fluid interface, thus achieving zero-order kinetics.