Patents by Inventor Gustavo E. Grampp

Gustavo E. Grampp has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Production of glycoproteins using manganese
    Patent number: 8617878
    Abstract: Culture media comprising manganese and methods of culturing cells to improve sialylation and glycosylation of glycoproteins are provided.
    Type: Grant
    Filed: May 20, 2011
    Date of Patent: December 31, 2013
    Assignee: Amgen Inc.
    Inventors: Christopher K. Crowell, Gustavo E. Grampp
  • PRODUCTION OF GLYCOPROTEINS USING MANGANESE
    Publication number: 20110287483
    Abstract: Culture media comprising manganese and methods of culturing cells to improve sialylation and glycosylation of glycoproteins are provided.
    Type: Application
    Filed: May 20, 2011
    Publication date: November 24, 2011
    Inventors: Christopher K. CROWELL, Gustavo E. GRAMPP
  • Production of glycoproteins using manganese
    Patent number: 7972810
    Abstract: Culture media comprising manganese and methods of culturing cells to improve sialylation and glycosylation of glycoproteins are provided.
    Type: Grant
    Filed: December 6, 2006
    Date of Patent: July 5, 2011
    Assignee: Amgen Inc.
    Inventors: Christopher K. Crowell, Gustavo E. Grampp
  • Methods for controlling sialic acid derivatives in recombinant glycoproteins
    Patent number: 5459031
    Abstract: The invention relates to the effects of certain cell culture and/or production parameters on the carbohydrate composition of a cell culture-derived recombinant glycoprotein. The methods of the invention demonstrate a practical method for controlling levels of a sialic acid derivative, NGNA, in secreted recombinant glycoproteins which will be useful in a variety of bioprocessing systems.
    Type: Grant
    Filed: June 17, 1994
    Date of Patent: October 17, 1995
    Assignee: Amgen Inc.
    Inventors: Tracy K. Blumen, Gustavo E. Grampp, David J. Hettwer