Abstract: Systems and methods for designing and optimizing tools are provided. A computational fluid dynamics (CFD) simulation model implemented by a processor is provided to simulate a fluid flow inside the tool to generate a particle density distribution of fluids inside the tool. The particle density distribution is converted to a spatial distribution of fluid concentration of the mixture which allows for high resolution visualization of fluid flow in the tool.

Abstract: Methods and apparatus including a fiber opening chamber having an open upper end and a lower end, at least one fiber inlet for introducing a multiplicity of fibers into the opening chamber, a first multiplicity of rollers positioned within the opening chamber wherein each roller has a multiplicity of projections extending outwardly from a circumferential surface surrounding a center axis of rotation, at least one gas emission nozzle positioned substantially below the first multiplicity of rollers to direct a gas stream generally towards the open upper end of the opening chamber, and a forming chamber having an upper end and a lower end, wherein the upper end of the forming chamber is in flow communication with the open upper end of the opening chamber, and the lower end of the forming chamber is substantially open and positioned above a collector having a collector surface.

Abstract: Methods and apparatus including a chamber having a substantially open lower end positioned above a collector surface, at least one fiber inlet positioned above the lower end, a first multiplicity of rollers positioned within the chamber wherein each roller has a multiplicity of projections extending outwardly from a circumferential surface surrounding a center axis of rotation, a second multiplicity of rollers positioned within the chamber above the first multiplicity of rollers wherein each of the second multiplicity of rollers has a multiplicity of projections extending outwardly from a circumferential surface surrounding a center axis of rotation, the second multiplicity of rollers positioned so at least a portion of the projections extending outwardly from the circumferential surfaces of each of the second multiplicity of rollers vertically overlaps with at least a portion of the projections extending outwardly from the circumferential surface of at least one of the first multiplicity of rollers.

Abstract: An apparatus for debriding a wound is provided. The apparatus comprises a curette head having a plurality of blades extending from a base. Each blade of the plurality of blades comprises a debridement edge and a longitudinal dimension. At least one first hollow channel extends through the first blade along the longitudinal dimension from a first opening proximate the base to at least one second opening that is integrated in the debridement edge of the first blade or that is disposed in a major surface of the first blade proximate the debridement edge. Methods of using the apparatus are also provided.

Abstract: Described herein is a construction comprising (a) a support sheet having a base, comprising (i) a plurality of rails extending from the base wherein each rail of the plurality of rails extends continuously down a length of the support sheet and each rail comprises a first side surface and an opposing second side surface and a top surface; and (ii) a plurality of first protrusions extending from the base, wherein the plurality of first protrusions are located between the plurality of rails; and (b) a selectively permeable membrane having a first major membrane surface contacting at least the top surface of at least two rails enclosing a flow channel having a height extending between the base of the support sheet and the first major membrane surface, wherein the plurality of protrusions change the height of the flow channel along its length along the longitudinal axis of the flow channel.

Abstract: Described herein is a construction comprising (a) a support sheet having a base, comprising (i) a plurality of rails extending from the base wherein each rail of the plurality of rails extends continuously down a length of the support sheet and each rail comprises a first side surface and an opposing second side surface and a top surface; and (ii) a plurality of first protrusions extending from the base, wherein the plurality of first protrusions are located between the plurality of rails; and (b) a selectively permeable membrane having a first major membrane surface contacting at least the top surface of at least two rails enclosing a flow channel having a height extending between the base of the support sheet and the first major membrane surface, wherein the plurality of protrusions change the height of the flow channel along its length along the longitudinal axis of the flow channel.

Abstract: Filter media including a microperforated film with tapered microperforations, and a nonwoven web positioned upstream of the microperforated film. Framed air filters incorporating such filter media, and methods of using such filter media.

Abstract: Filter media including a microperforated film with tapered microperforations, and a nonwoven web positioned upstream of the microperforated film. Framed air filters incorporating such filter media, and methods of using such filter media.

Abstract: Methods and apparatus including a fiber opening chamber having an open upper end and a lower end, at least one fiber inlet for introducing a multiplicity of fibers into the opening chamber, a first multiplicity of rollers positioned within the opening chamber wherein each roller has a multiplicity of projections extending outwardly from a circumferential surface surrounding a center axis of rotation, at least one gas emission nozzle positioned substantially below the first multiplicity of rollers to direct a gas stream generally towards the open upper end of the opening chamber, and a forming chamber having an upper end and a lower end, wherein the upper end of the forming chamber is in flow communication with the open upper end of the opening chamber, and the lower end of the forming chamber is substantially open and positioned above a collector having a collector surface.

Abstract: Methods and apparatus including a chamber having a substantially open lower end positioned above a collector surface, at least one fiber inlet positioned above the lower end, a first multiplicity of rollers positioned within the chamber wherein each roller has a multiplicity of projections extending outwardly from a circumferential surface surrounding a center axis of rotation, a second multiplicity of rollers positioned within the chamber above the first multiplicity of rollers wherein each of the second multiplicity of rollers has a multiplicity of projections extending outwardly from a circumferential surface surrounding a center axis of rotation, the second multiplicity of rollers positioned so at least a portion of the projections extending outwardly from the circumferential surfaces of each of the second multiplicity of rollers vertically overlaps with at least a portion of the projections extending outwardly from the circumferential surface of at least one of the first multiplicity of rollers.

Abstract: Static mixers and fluid systems incorporating one or more of the static mixers. The static mixers include a mixing structure formed within a body, wherein fluid flowing through the mixing structure defines a downstream direction through the mixing structure. The mixing structure includes a series of Y-shaped channels that cross to provide flowpaths that result in efficient mixing.

Abstract: A sample acquisition device includes a capillary array configured to draw in a sample and retain the sample by capillary action. The capillary array may be coupled to an elongated member, such as a stem or a hollow tube, which defines a longitudinal axis extending in a first direction. In some embodiments, the capillary array defines a major sample acquisition surface that extends in a second direction different than the first direction. A ratio of the major sample acquisition surface area to maximum volume retained by the capillary array may be selected to minimize physical binding between the capillary array and sample. In some embodiments, the device may include a feedback mechanism to indicate the relative pressure applied to a sample source with the sample acquisition device. In addition, in some embodiments, the sample acquisition device may include a suction source to help draw the sample into the capillary array.

Abstract: A sample acquisition device includes a body comprising a plurality of sample acquisition regions defined by at least a first wall and a second wall oriented nonparallel to the first wall. In some embodiments, the body defines a plurality of apertures that define a plurality of sample acquisition regions. In other embodiments, the walls extend from the body, and the sample acquisition regions are defined between the walls. The sample acquisition regions may be configured in some embodiments such that a user may acquire a sample by rotating the body in a first direction relative to a sample source and may release the sample by rotating the body in a second direction that is substantially opposite to the first direction. When rotated in the first direction, at least one of the first or second walls defines a surface that is inclined into a sample acquisition region.

Abstract: Static mixers and fluid systems incorporating one or more of the static mixers. The static mixers include a mixing structure formed within a body, wherein fluid flowing through the mixing structure defines a downstream direction through the mixing structure. The mixing structure includes a series of Y-shaped channels that cross to provide flowpaths that result in efficient mixing.

Abstract: Static mixers and fluid systems incorporating one or more of the static mixers. The static mixers include one or more channels that provide a fluid path through a body, wherein fluid flowing through each channel defines a downstream direction through the channel. The channel includes two or more sets of concatenated mixing elements arranged adjacent to each other across the width of the channel, wherein two sets of the mixing elements are offset from each other along the downstream direction of the channel.

Abstract: Static mixers and fluid systems incorporating one or more of the static mixers. The static mixers may include one or more channels that provide a tortuous path through a body, wherein fluid flowing through each channel defines a downstream direction through the tortuous path created within the channel. The tortuous path of the channel is preferably formed by a set of flow obstacles protruding into the channel and a set of flow restrictions positioned along the channel between the inlet and the outlet. Each flow restriction has a downstream length over which the open cross-sectional area of the channel decreases and then increases when moving in the downstream direction.

Abstract: A sample acquisition device includes a capillary array configured to draw in a sample and retain the sample by capillary action. The capillary array may be coupled to an elongated member, such as a stem or a hollow tube, which defines a longitudinal axis extending in a first direction. In some embodiments, the capillary array defines a major sample acquisition surface that extends in a second direction different than the first direction. A ratio of the major sample acquisition surface area to maximum volume retained by the capillary array may be selected to minimize physical binding between the capillary array and sample. In some embodiments, the device may include a feedback mechanism to indicate the relative pressure applied to a sample source with the sample acquisition device. In addition, in some embodiments, the sample acquisition device may include a suction source to help draw the sample into the capillary array.

Abstract: The application discloses embodiments of detection devices including a sensor component in a flow path between a first flow path portion and a second flow path portion. In embodiments described, the sensor component includes a receptor in a polymerized composition. The receptor is configured to bind with an analyte in a test sample. Upon binding the sensor component undergoes a detectable change in response to interaction of the analyte with the receptor.

Abstract: Valve stems for use in an aerosol metering valve are described herein. The valve stems include structures designed to limit the likelihood and extent to which a gasket can intrude into an opening in the valve stem. The valve stems described herein also limit the likelihood and extent of damage to the gasket caused by repeated use of the metering valve.

Abstract: A novel metering valve having improved flow for delivery of an aerosol formulation is disclosed. Methods of delivering an aerosol formulation using a device comprising the novel metering valve are also disclosed.