Abstract: Ultrafine particles are provided having a core region that has a signal amplifying molecule and a shell region that surrounds the core region. The shell region has at least one antibody affixed to its surface that is specific for at least one antigen. Alternatively, the ultrafine particles may entrap the signal amplifying molecule within its matrix and may also have antibodies affixed to its surface for molecular recognition. Ultrafine particles are also provided having a matrix component that includes a signal amplifying molecule and at least one antibody specific for the antigen or biomaterial. The ultrafine particles of the present disclosure may be used in assays for the detection, including quantification, of one or more antigens present in a biological sample.

Abstract: Capsules and particles with at least one encapsulated and/or entrapped agent, such as therapeutic agent, imaging agents, and other constituents may be produced by electrohydrodynamic processes. More particularly, the agent encapsulated in a vehicle, capsule, particle, vector, or carrier may maximize treatment and/or imaging of malignant cancers while minimizing the adverse effects of treatment and/or imaging.

Abstract: Capsules and particles with at least one encapsulated and/or entrapped agent, such as therapeutic agent, imaging agents, and other constituents may be produced by electrohydrodynamic processes. More particularly, the agent encapsulated in a vehicle, capsule, particle, vector, or carrier may maximize treatment and/or imaging of malignant cancers while minimizing the adverse effects of treatment and/or imaging.

Abstract: A method of manufacturing a sturdy and pliable fibrous hemostatic dressing by making fibers that maximally expose surface area per unit weight of active ingredients as a means for aiding in the clot forming process and as a means of minimizing waste of active ingredients. The method uses a rotating object to spin off a liquid biocompatible fiber precursor, which is added at its center. Fibers formed then deposit on a collector located at a distance from the rotating object creating a fiber layer on the collector. An electrical potential difference is maintained between the rotating disk and the collector. Then, a liquid procoagulation species is introduced at the center of the rotating disk such that it spins off the rotating disk and coats the fibers.

Abstract: A method of manufacturing a sturdy and pliable fibrous hemostatic dressing by making fibers that maximally expose surface area per unit weight of active ingredients as a means for aiding in the clot forming process and as a means of minimizing waste of active ingredients. The method uses a rotating object to spin off a liquid biocompatible fiber precursor, which is added at its center. Fibers formed then deposit on a collector located at a distance from the rotating object creating a fiber layer on the collector. An electrical potential difference is maintained between the rotating disk and the collector. Then, a liquid procoagulation species is introduced at the center of the rotating disk such that it spins off the rotating disk and coats the fibers.

Abstract: A method of making a pliable, bioabsorbable hemostatic dressing wherein the dressing is composed of fibers with at least one molecular-scale coating, which upon first contact with blood and due to a large area of contact with blood per unit weight of active ingredients, initiates and accelerates the biochemical blood clotting cascade processes.

Abstract: A method for organizing and controlling cell growth on a cell-free structure comprises steps of decellularizing a biological material to produce an acellular matrix; adding cells sought to be propagated to the acellular matrix; coating the acellular matrix with a fiber comprising biological and nonbiological material; and storing the covered acellular matrix for a time sufficient to form organized cell growth in the three-dimensional structural shape. The method may include the step of covering the three-dimensional structural shape by a structural layer to enable generation of a replacement external organ. This structural layer comprises a polymer film and fiber with a biological material and a nonbiological material. The biological material includes a cell growth factor; and the nonbiological material includes magnetite. This structural layer also comprises a therapeutic at a concentration between 0.001 and 5 weight percent. This structural layer may also comprise an acellular matrix of an organ.

Abstract: Ultrafine particles are provided having a core region that has a signal amplifying molecule and a shell region that surrounds the core region. The shell region has at least one antibody affixed to its surface that is specific for at least one antigen. Alternatively, the ultrafine particles may entrap the signal amplifying molecule within its matrix and may also have antibodies affixed to its surface for molecular recognition. Ultrafine particles are also provided having a matrix component that includes a signal amplifying molecule and at least one antibody specific for the antigen or biomaterial. The ultrafine particles of the present disclosure may be used in assays for the detection, including quantification, of one or more antigens present in a biological sample.

Abstract: A method of making a pliable, bioabsorbable hemostatic dressing wherein the dressing is composed of fibers with at least one molecular-scale coating, which upon first contact with blood and due to a large area of contact with blood per unit weight of active ingredients, initiates and accelerates the biochemical blood clotting cascade processes.

Abstract: A method of manufacturing a sturdy and pliable fibrous hemostatic dressing by making fibers that maximally expose surface area per unit weight of active ingredients as a means for aiding in the clot forming process and as a means of minimizing waste of active ingredients. The method uses a rotating object to spin off a liquid biocompatible fiber precursor, which is added at its center. Fibers formed then deposit on a collector located at a distance from the rotating object creating a fiber layer on the collector. An electrical potential difference is maintained between the rotating disk and the collector. Then, a liquid procoagulation species is introduced at the center of the rotating disk such that it spins off the rotating disk and coats the fibers.

Abstract: Capsules and particles with at least one encapsulated and/or entrapped agent, such as therapeutic agent, imaging agents, and other constituents may be produced by electrohydrodynamic processes. More particularly, the agent encapsulated in a vehicle, capsule, particle, vector, or carrier may maximize treatment and/or imaging of malignant cancers while minimizing the adverse effects of treatment and/or imaging.

Abstract: Capsules and particles with at least one encapsulated and/or entrapped agent, such as therapeutic agent, imaging agents, and other constituents may be produced by electrohydrodynamic processes. More particularly, the agent encapsulated in a vehicle, capsule, particle, vector, or carrier may maximize treatment and/or imaging of malignant cancers while minimizing the adverse effects of treatment and/or imaging.

Abstract: A cellulose/silica composite useful as a filter material is highly selective towards a solute that has been molecularly imprinted upon an inorganic gel coating formed on the cellulose. The filter material provides dual filtering functionality, as both a selective molecular sieve and as a particulate filter. A unique method for making the filter material is also set forth that imparts these attributes and performance capabilities.

Abstract: A cellulose/silica composite useful as a filter material is highly selective towards a solute that has been molecularly imprinted upon an inorganic gel coating formed on the cellulose. The filter material provides dual filtering functionality, as both a selective molecular sieve and as a particulate filter. A unique method for making the filter material is also set forth that imparts these attributes and performance capabilities.

Abstract: Stable cellulosic fiber material for use in forming zeolite/cellulose composites is prepared by suspending loose cellulose fibers in an aqueous solution of sodium hydroxide, potassium hydroxide or sodium silicate, stirring the resulting suspension until it reaches a macroscopically homogenous appearance, heating the resulting mixture at a temperature of 323-423 K until only dry solids remain, contacting the resulting mixture with excess distilled water to remove physically adsorbed or trapped sodium hydroxide, potassium hydroxide or sodium silicate from the fibers, and heating the resulting fiber material at 323-423 K to dry the fiber material. Stable zeolite/cellulose composite material characterized in that leaching of the zeolite phase does not occur upon contact of the composite with water at approximately 373 K comprises a zeolite and a stable cellulosic fiber prepared as described above, the composite material being formed by contacting a zeolite with the stable fiber material.

Abstract: Stable cellulosic fiber material for use in forming zeolite/cellulose composites is prepared by suspending loose cellulose fibers in an aqueous solution of sodium hydroxide, potassium hydroxide or sodium silicate, stirring the resulting suspension until it reaches a macroscopically homogenous appearance, heating the resulting mixture at a temperature of 323-423 K until only dry solids remain, contacting the resulting mixture with excess distilled water to remove physically adsorbed or trapped sodium hydroxide, potassium hydroxide or sodium silicate from the fibers, and heating the resulting fiber material at 323-423 K to dry the fiber material. Stable zeolite/cellulose composite material characterized in that leaching of the zeolite phase does not occur upon contact of the composite with water at approximately 373 K comprises a zeolite and a stable cellulosic fiber prepared as described above, the composite material being formed by contacting a zeolite with the stable fiber material.

Abstract: New compositions of matter comprise a metal from the group consisting of platinum, rhodium and palladium, a metal from the first row of Group VIII of the Periodic Table and a nonacidic L-zeolite. A preferred composition is Pt--Ni/KL-zeolite. Such catalysts are prepared by coimpregnation of the zeolite with the metals. Methods of using the catalysts in reforming, aromatization or dehydrogenation are provided.