Patents by Inventor Gustavo Leónidas Vera Janavel

Gustavo Leónidas Vera Janavel has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHOD TO INDUCE NEOVASCULAR FORMATION AND TISSUE REGENERATION
    Publication number: 20090275645
    Abstract: The present invention relates, e.g., to a method for inducing arteriogenesis, lymphangiogenesis, vasculogenesis, or cardiomyogenesis, and/or for inducing mitosis or proliferation of a smooth muscle cell, a skeletal muscle cell, or a cardiomyocyte, comprising administering to a cell or tissue in need thereof a dose of a polynucleotide that encodes a vascular endothelial growth factor (VEGF), or that encodes a polypeptide comprising an active site of the VEGF. The coding sequence is operably linked to an expression control sequence; and the dose is sufficient to induce arteriogenesis, lymphangiogenesis, vasculogenesis, or cardiomyogenesis, and/or to induce mitosis or proliferation of a smooth muscle cell, a skeletal muscle cell, or a cardiomyocyte. In preferred embodiments of the invention, the method is a method of tissue regeneration, particularly of cardiomyogenesis; and the polynucleotide (or a polypeptide encoded by such a polynucleotide) is administered into the myocardium.
    Type: Application
    Filed: June 18, 2009
    Publication date: November 5, 2009
    Applicants: Sterrenbeld Biotechnologie North America, Inc., Fundacion Universitaria Dr. Rene G. Favaloro
    Inventors: Rubén Laguens, Marcelo L. Arguelles, Gustavo Leónidas Vera Janavel, José Alberto Crottogini, Carlos Alberto Melo, Ricardo Horacio Pichel, Marcelo Eduardo Criscuolo
  • Method to induce neovascular formation and tissue regeneration
    Patent number: 7563777
    Abstract: The present invention relates, e.g., to a method for inducing arteriogenesis, lymphangiogenesis, vasculogenesis, or cardiomyogenesis, and/or for inducing mitosis or proliferation of a smooth muscle cell, a skeletal muscle cell, or a cardiomyocyte, comprising administering to a cell or tissue in need thereof a dose of a polynucleotide that encodes a vascular endothelial growth factor (VEGF), or that encodes a polypeptide comprising an active site of the VEGF. The coding sequence is operably linked to an expression control sequence; and the dose is sufficient to induce arteriogenesis, lymphangiogenesis, vasculogenesis, or cardiomyogenesis, and/or to induce mitosis or proliferation of a smooth muscle cell, a skeletal muscle cell, or a cardiomyocyte. In preferred embodiments of the invention, the method is a method of tissue regeneration, particularly of cardiomyogenesis; and the polynucleotide (or a polypeptide encoded by such a polynucleotide) is administered into the myocardium.
    Type: Grant
    Filed: November 17, 2003
    Date of Patent: July 21, 2009
    Assignees: Sterrenbeld Biotechnologie North America, Inc., Fundacion Universitaria Dr. Rene G. Favaloro
    Inventors: Rubén Laguens, Marcelo L. Argüelles, Gustavo Leónidas Vera Janavel, José Alberto Crottogini, Carlos Alberto Melo, Ricardo Horacio Pichel, Marcelo Eduardo Criscuolo