Patents by Inventor Gusui Wu

Gusui Wu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11028407
    Abstract: The disclosure provides nucleic acids, and variants and fragments thereof, derived from strains of Bacillus thuringiensis encoding variant polypeptides having increased pesticidal activity against insect pests, including Lepidoptera and Coleopteran. Particular embodiments of the disclosure provide isolated nucleic acids encoding pesticidal proteins, pesticidal compositions, DNA constructs, and transformed microorganisms and plants comprising a nucleic acid of the embodiments. These compositions find use in methods for controlling pests, especially plant pests.
    Type: Grant
    Filed: April 19, 2017
    Date of Patent: June 8, 2021
    Inventors: Albert L Lu, Gusui Wu
  • Patent number: 10876132
    Abstract: Compositions and methods for controlling pests are provided. The methods involve transforming organisms with one or more nucleic acid sequence encoding insecticidal protein(s) and one or more silencing element(s). In particular, the nucleic acid sequences are useful for preparing plants and microorganisms that possess insecticidal activity. Thus, transformed bacteria, plants, plant cells, plant tissues and seeds are provided. Compositions are insecticidal nucleic acids and proteins of bacterial species. The sequences find use in the construction of expression vectors for subsequent transformation into organisms of interest including plants, as probes for the isolation of other homologous (or partially homologous) genes. The molecular and breeding stacks find use in controlling, inhibiting growth or killing Lepidopteran, Coleopteran, Dipteran, fungal, Hemipteran and nematode pest populations and for producing compositions with insecticidal activity.
    Type: Grant
    Filed: March 3, 2016
    Date of Patent: December 29, 2020
    Assignees: E I DU PONT DE NEMOURS AND COMPANY
    Inventors: Scott Henry Diehn, Xu Hu, Albert L. Lu, Lu Liu, James Kevin Presnail, Gary A. Sandahl, Ute Schellenberger, Gusui Wu
  • Publication number: 20200332314
    Abstract: Compositions and methods for controlling pests are provided. The methods involve transforming organisms with a nucleic acid sequence encoding an insecticidal protein. In particular, the nucleic acid sequences are useful for preparing plants and microorganisms that possess insecticidal activity. Thus, transformed bacteria, plants, plant cells, plant tissues and seeds are provided. Compositions are insecticidal nucleic acids and proteins of bacterial species. The sequences find use in the construction of expression vectors for subsequent transformation into organisms of interest including plants, as probes for the isolation of other homologous (or partially homologous) genes. The pesticidal proteins find use in controlling, inhibiting growth or killing Lepidopteran, Coleopteran, Dipteran, fungal, Hemipteran and nematode pest populations and for producing compositions with insecticidal activity.
    Type: Application
    Filed: November 29, 2018
    Publication date: October 22, 2020
    Applicant: PIONEER HI-BRED INTERNATIONAL, INC.
    Inventors: ALBERT L LU, KNUT MEYER, GILDA RAUSCHER, GUSUI WU
  • Publication number: 20200308598
    Abstract: The disclosure provides nucleic acids, and variants and fragments thereof, derived from strains of Bacillus thuringiensis encoding variant polypeptides having increased pesticidal activity against insect pests, including Lepidoptera and Coleopteran. Particular embodiments of the disclosure provide isolated nucleic acids encoding pesticidal proteins, pesticidal compositions, DNA constructs, and transformed microorganisms and plants comprising a nucleic acid of the embodiments. These compositions find use in methods for controlling pests, especially plant pests.
    Type: Application
    Filed: April 18, 2018
    Publication date: October 1, 2020
    Applicant: PIONEER HI-BRED INTERNATIONAL, INC.
    Inventors: ALBERT L LU, MARK EDWARD NELSON, GUSUI WU, TAKASHI YAMAMOTO
  • Publication number: 20200224216
    Abstract: Compositions and methods for controlling pests are provided. The methods involve transforming organisms with a nucleic acid sequence encoding an insecticidal protein. In particular, the nucleic acid sequences are useful for preparing plants and microorganisms that possess insecticidal activity. Thus, transformed bacteria, plants, plant cells, plant tissues and seeds are provided. Compositions are insecticidal nucleic acids and proteins of bacterial species. The sequences find use in the construction of expression vectors for subsequent transformation into organisms of interest including plants, as probes for the isolation of other homologous (or partially homologous) genes. The pesticidal proteins find use in controlling, inhibiting growth or killing Lepidopteran, Coleopteran, Dipteran, fungal, Hemipteran and nematode pest populations and for producing compositions with insecticidal activity.
    Type: Application
    Filed: January 11, 2018
    Publication date: July 16, 2020
    Applicant: PIONEER HI-BRED INTERNATIONAL, INC.
    Inventors: NURIA JIMENEZ-JUAREZ, ALBERT L LU, LU LIU, MARK EDWARD NELSON, GUSUI WU
  • Publication number: 20200196612
    Abstract: This disclosure relates to the field of molecular biology. Provided are novel genes that encode pesticidal proteins. These pesticidal proteins and the nucleic acid sequences that encode them are useful in preparing pesticidal formulations and in the production of transgenic pest-resistant plants. Methods to create or alter pesticidal proteins are provided for altered or enhanced pesticidal activity.
    Type: Application
    Filed: December 18, 2019
    Publication date: June 25, 2020
    Applicants: PIONEER HI-BRED INTERNATIONAL, INC., CHINESE ACADEMY OF AGRICULTURAL SCIENCES
    Inventors: JENNIFER KARA BARRY, THOMAS CHAD WOLFE, GUSUI WU, JIAN-ZHOU ZHAO, YUEMING SHAN, CHANGLONG SHU, JIE ZHANG
  • Publication number: 20200140882
    Abstract: The disclosure provides nucleic acids, and variants and fragments thereof, derived from strains of Bacillus thuringiensis encoding variant polypeptides having increased pesticidal activity against insect pests, including Lepidoptera and Coleopteran. Particular embodiments of the disclosure provide isolated nucleic acids encoding pesticidal proteins, pesticidal compositions, DNA constructs, and transformed microorganisms and plants comprising a nucleic acid of the embodiments. These compositions find use in methods for controlling pests, especially plant pests.
    Type: Application
    Filed: April 19, 2017
    Publication date: May 7, 2020
    Applicants: PIONEER HI-BRED INTERNATIONAL, INC., E. I. DU PONT DE NEMOURS AND COMPANY
    Inventors: ALBERT L LU, GUSUI WU
  • Publication number: 20190390219
    Abstract: Compositions and methods for controlling pests are provided. The methods involve transforming organisms with a nucleic acid sequence encoding a silencing element and an insecticidal protein. In particular, the nucleic acid sequences are useful for preparing plants and microorganisms that possess insecticidal activity. Thus, transformed bacteria, plants, plant cells, plant tissues and seeds are provided. Compositions are insecticidal nucleic acids and proteins of bacterial species. The sequences find use in the construction of expression vectors for subsequent transformation into organisms of interest including plants, as probes for the isolation of other homologous (or partially homologous) genes. The pesticidal proteins find use in controlling, inhibiting growth or killing Lepidopteran, Coleopteran, Dipteran, Hemipteran, fungi and nematode pest populations and for producing compositions with insecticidal activity.
    Type: Application
    Filed: January 22, 2018
    Publication date: December 26, 2019
    Applicant: PIONEER HI-BRED INTERNATIONAL, INC.
    Inventors: CHAD THOMAS BARRETT, XU HU, ALBERT L LU, LAURA J RUTTMAN, GUSUI WU
  • Publication number: 20190292543
    Abstract: The present invention relates generally to methods of molecular biology and gene silencing to control pests.
    Type: Application
    Filed: December 13, 2017
    Publication date: September 26, 2019
    Applicant: PIONEER HI-BRED INTERNATIONAL, INC.
    Inventors: VIRGINIA CRANE, JOHN LINDSEY FLEXNER, XU HU, ADANE KASSA, ALBERT L. LU, XIPING NIU, ZAIQI PAN, AMIT SETHI, GUSUI WU
  • Publication number: 20180042242
    Abstract: Compositions and methods for controlling pests are provided. The methods involve transforming organisms with one or more nucleic acid sequence encoding insecticidal protein(s) and one or more silencing element(s). In particular, the nucleic acid sequences are useful for preparing plants and microorganisms that possess insecticidal activity. Thus, transformed bacteria, plants, plant cells, plant tissues and seeds are provided. Compositions are insecticidal nucleic acids and proteins of bacterial species. The sequences find use in the construction of expression vectors for subsequent transformation into organisms of interest including plants, as probes for the isolation of other homologous (or partially homologous) genes. The molecular and breeding stacks find use in controlling, inhibiting growth or killing Lepidopteran, Coleopteran, Dipteran, fungal, Hemipteran and nematode pest populations and for producing compositions with insecticidal activity.
    Type: Application
    Filed: March 3, 2016
    Publication date: February 15, 2018
    Applicants: PIONEER HI-BRED INTERNATIONAL, INC., E. I. DU PONT DE NEMOURS AND COMPANY
    Inventors: SCOTT HENRY DIEHN, XU HU, ALBERT L. LU, LU LIU, JAMES KEVIN PRESNAIL, GARY A. SANDAHL, UTE SCHELLENBERGER, GUSUI WU
  • Publication number: 20160168587
    Abstract: The present invention comprises methods and compositions for controlling nematode parasitism in host plant. The present invention comprises novel polynucleotides and polypeptides encoded by such polynucleotides comprising one or more nucleic acid sequences disclosed herein having a nucleotide sequence comprising any one of SEQ ID NO: 1-142 or 161, a fragment or variant thereof, or a complement thereof, or a polypeptide sequence comprising any one of SEQ ID NO: 143-160, a fragment or variant thereof.
    Type: Application
    Filed: March 12, 2014
    Publication date: June 16, 2016
    Inventors: Jun-Zhi Wei, Gusui Wu, Carl Simmons, Thomas Baum, Eric Davis, Richard Hussey, Melissa G. Mitchum
  • Publication number: 20140275213
    Abstract: The present invention comprises methods and compositions for controlling nematode parasitism in host plant. The present invention comprises novel polynucleotides and polypeptides encoded by such polynucleotides comprising one or more nucleic acid sequences disclosed herein having a nucleotide sequence comprising any one of SEQ ID NOs: 1-142, a fragment or variant thereof, or a complement thereof, or a polypeptide sequence comprising any one of SEQ ID NOs: 143-159, a fragment or variant thereof.
    Type: Application
    Filed: March 12, 2014
    Publication date: September 18, 2014
    Applicants: Pioneer Hi-Bred International, Inc., Iowa State University Research Foundation, Inc., The Curators of the University of Missouri, University of Georgia Research Foundation, Inc., North Carolina State University
    Inventors: Jun-zhi Wei, Gusui Wu, Carl R. Simmons, Thomas Baum, Eric Davis, Richard Hussey, Melissa G. Mitchum
  • Patent number: 8735147
    Abstract: The invention provides novel cyclotide polypeptides, and variants and fragments thereof, obtained from Butterfly pea and having pesticidal activity against nematodes. Particular embodiments of the invention provide isolated nucleic acids encoding pesticidal proteins, biopesticide compositions, expression cassettes, and transformed microorganisms and plants comprising a nucleic acid of the invention. These compositions find use in methods for controlling pests, especially plant-parasitic pests such as nematodes and insects.
    Type: Grant
    Filed: April 4, 2012
    Date of Patent: May 27, 2014
    Assignee: Pioneer Hi Bred International Inc
    Inventors: Daniel J. Altier, Xuehua Hu, Daniel L. Siehl, Jun-Zhi Wei, Gusui Wu
  • Publication number: 20130029844
    Abstract: The invention provides novel cyclotide polypeptides, and variants and fragments thereof, obtained from Butterfly pea and having pesticidal activity against nematodes. Particular embodiments of the invention provide isolated nucleic acids encoding pesticidal proteins, biopesticide compositions, expression cassettes, and transformed microorganisms and plants comprising a nucleic acid of the invention. These compositions find use in methods for controlling pests, especially plant-parasitic pests such as nematodes and insects.
    Type: Application
    Filed: April 4, 2012
    Publication date: January 31, 2013
    Applicant: PIONEER HI BRED INTERNATIONAL INC.
    Inventors: Daniel J. Altier, Xuehua Hu, Daniel L. Siehl, Jun-Zhi Wei, Gusui Wu
  • Publication number: 20110191903
    Abstract: Methods for identifying one or more amino acid substitutions in an oxalate oxidase (OXOX) variant polypeptide that confer maintained or increased OXOX activity are described herein. Methods and compositions for increasing a plant's resistance to a pathogen using the modified OXOX variant polypeptides are provided. Transformed plants, plant cell, tissues, seed, and expression vectors are also provided.
    Type: Application
    Filed: December 30, 2010
    Publication date: August 4, 2011
    Applicant: Pioneer Hi-Bred International, Inc.
    Inventors: James Joseph English, Xu Hu, Azalea Sukfun Ong, Daniel J. Thorpe, Gusui Wu
  • Patent number: 7785828
    Abstract: The invention relates to a method of producing cysteine containing polypeptides in fusion proteins by recombinantly expressing in a host cell sequences encoding an antifungal polypeptide, a maltose binding protein, and a histidine tag. The method is carried out in the presence of a reducing agent to prevent misfolding of the fusion proteins.
    Type: Grant
    Filed: February 6, 2004
    Date of Patent: August 31, 2010
    Assignee: Pioneer Hi-Bred International, Inc.
    Inventors: Gusui Wu, Wessel Lageweg, Maarten H. Stuiver, Lu Liu, Wei Wei, Michael A. Dojka, Jr., Linda K. Dojka, legal representative
  • Patent number: 7528293
    Abstract: Methods for protecting a plant from a plant pathogenic fungus are provided. A method for enhancing fungal pathogen resistance in a plant using the nucleotide sequences disclosed herein is further provided. The method comprises introducing into a plant an expression cassette comprising a promoter operably linked to a nucleotide sequence that encodes an antifungal polypeptide of the invention. Transformed plants, plant cells, seeds, and microorganisms comprising a nucleotide sequence that encodes an antifungal polypeptide of the embodiments, or variant or fragment thereof, are also disclosed.
    Type: Grant
    Filed: December 14, 2007
    Date of Patent: May 5, 2009
    Assignee: Pioneer Hi-Bred International, Inc.
    Inventors: Hana S. Ali, Robert J. Keenan, Michael Lassner, Mathias L. Muller, Gusui Wu
  • Patent number: 7511188
    Abstract: Methods for protecting a plant from a plant pathogenic fungus are provided. A method for enhancing fungal pathogen resistance in a plant using the nucleotide sequences disclosed herein is further provided. The method comprises introducing into a plant an expression cassette comprising a promoter operably linked to a nucleotide sequence that encodes an antifungal polypeptide of the invention. Transformed plants, plant cells, seeds, and microorganisms comprising a nucleotide sequence that encodes an antifungal polypeptide of the embodiments, or variant or fragment thereof, are also disclosed.
    Type: Grant
    Filed: December 14, 2007
    Date of Patent: March 31, 2009
    Assignee: Pioneer Hi-Bred International, Inc.
    Inventors: Hana S. Ali, Robert J. Keenan, Michael Lassner, Mathias L. Muller, Gusui Wu
  • Publication number: 20080127375
    Abstract: Methods for protecting a plant from a plant pathogenic fungus are provided. A method for enhancing fungal pathogen resistance in a plant using the nucleotide sequences disclosed herein is further provided. The method comprises introducing into a plant an expression cassette comprising a promoter operably linked to a nucleotide sequence that encodes an antifungal polypeptide of the invention. Transformed plants, plant cells, seeds, and microorganisms comprising a nucleotide sequence that encodes an antifungal polypeptide of the embodiments, or variant or fragment thereof, are also disclosed.
    Type: Application
    Filed: December 14, 2007
    Publication date: May 29, 2008
    Inventors: Hana S. Ali, Robert J. Keenan, Michael Lassner, Mathias L. Muller, Gusui Wu
  • Publication number: 20080120741
    Abstract: Methods for protecting a plant from a plant pathogenic fungus are provided. A method for enhancing fungal pathogen resistance in a plant using the nucleotide sequences disclosed herein is further provided. The method comprises introducing into a plant an expression cassette comprising a promoter operably linked to a nucleotide sequence that encodes an antifungal polypeptide of the invention. Transformed plants, plant cells, seeds, and microorganisms comprising a nucleotide sequence that encodes an antifungal polypeptide of the embodiments, or variant or fragment thereof, are also disclosed.
    Type: Application
    Filed: December 14, 2007
    Publication date: May 22, 2008
    Inventors: Hana S. Ali, Robert J. Keenan, Michael Lassner, Mathias L. Muller, Gusui Wu