Abstract: A method for vascular assessment is disclosed. The method comprises receiving a plurality of 2D angiographic images of a portion of a vasculature of a subject, and processing the images to produce a stenotic model over the vasculature, the stenotic model having measurements of the vasculature at one or more locations along vessels of the vasculature. The method further comprises obtaining a flow characteristic of the stenotic model, and calculating an index indicative of vascular function, based, at least in part, on the flow characteristic in the stenotic model.

Abstract: A method for vascular assessment is disclosed. The method includes receiving a plurality of medical images of a portion of a vasculature of a subject and processing the medical images to produce a model of the vasculature. The method further includes obtaining a flow characteristic of the model and calculating an index indicative of vascular function, based, at least in part, on the flow characteristic in the model.

Abstract: A method for vascular modeling is disclosed. The method, in some embodiments, comprises receiving a plurality of 2-D angiographic images of a portion of a vasculature of a subject, and processing the images to automatically detect 2-D features, for example, paths along vascular extents, which are projected into 3-D to determine homologous features among blood vessels. In some embodiments, projection and/or image registration is iteratively altered to improve feature position matching. Based on 3-D vascular extents and their registration to 2-D images, additional features such as vascular width are optionally determined and added to the model.

Abstract: Automated image analysis used in vascular state modeling. Coronary vasculature in particular is modeled in some embodiments. Methods of “virtual revascularization” of a presently stenotic vasculature are described; useful, for example, as a reference in disease state determinations. Structure and uses of a model which relates records comprising acquired images or other structured data to a vascular tree representation are described.

Abstract: A teletherapy control system constituted of: a teletherapy management server; and a computerized tomography unit in communication with the teletherapy management server, the teletherapy management server arranged to: obtain at least one reference image of a target area; obtain from the computerized tomography unit at least one scout image of the target area; compare the obtained at least one scout image of the target area with the obtained at least one reference image of the target area; identify the location coordinates of the target area responsive to the comparison of the obtained scout image with the obtained at least one reference image; and output a control signal to a positioning device responsive to the identified location coordinates of the target area.

Abstract: A method for vascular assessment is disclosed. The method, in some embodiments, comprises receiving a plurality of 2-D angiographic images of a portion of a vasculature of a subject, and processing the images to produce a stenotic model over the vasculature, the stenotic model having measurements of the vasculature at one or more locations along vessels of the vasculature. The method, in some embodiments, further comprises obtaining a flow characteristic of the stenotic model, and calculating an index indicative of vascular function, based, at least in part, on the flow characteristic in the stenotic model.

Abstract: Method for real-time vascular modeling and assessment. Modeling, in some embodiments, comprises receiving a plurality of 2-D angiographic images of a portion of a vasculature of a subject, and processing the images to automatically detect 2-D features, for example, paths along vascular extents, which are projected into 3-D to determine homologous features among blood vessels and construct 3-D vascular extents and determine other vascular characteristics. Assessment, in some embodiments, comprises processing models selectively different from one another to produce one or more vascular indexes which indicate a diagnostic preference, for example, to perform a medical intervention such as a stent implantation. Speed is achieved, for example, by the method being optimized for determining the effects of a medical intervention. In some embodiments, results are produced quickly enough to allow use of the method to perform PCI within the same catheterization used to perform diagnostic imaging.

Abstract: A method for vascular modeling is disclosed. The method, in some embodiments, comprises receiving a plurality of 2-D angiographic images of a portion of a vasculature of a subject, and processing the images to automatically detect 2-D features, for example, paths along vascular extents, which are projected into 3-D to determine homologous features among blood vessels. In some embodiments, projection and/or image registration is iteratively altered to improve feature position matching. Based on 3-D vascular extents and their registration to 2-D images, additional features such as vascular width are optionally determined and added to the model.

Abstract: Automated image analysis used in vascular disease characterization. Coronary vasculature in particular is automatically characterized in some embodiments for lesion complexity and related anatomical and/or functional parameters related to disease state. In some embodiments, a “virtual revascularization” model is used as a reference in disease state determinations. In some embodiments, disease parameters are determined for application by a disease characterization tool such as a SYNTAX Score calculator.

Abstract: A method for visualizing a region of interest within a viewport includes presenting tomographic image data as an image in a viewport using a set of global image processing operations, presenting a viewing window in the main viewport; and using a second, different set of image processing operations that is local to the viewing window, wherein the second, different set of image processing operations reduces image artifact with respect to a desired structure of interest in the viewing window.

Abstract: A method for vascular assessment is disclosed. The method comprises receiving a plurality of 2D angiographic images of a portion of a vasculature of a subject, and processing the images to produce a stenotic model over the vasculature, the stenotic model having measurements of the vasculature at one or more locations along vessels of the vasculature. The method further comprises obtaining a flow characteristic of the stenotic model, and calculating an index indicative of vascular function, based, at least in part, on the flow characteristic in the stenotic model.

Abstract: A method of adjusting an irradiation treatment plan, the plan constituted of: obtaining a plurality of reference scans of a target tissue over a breathing cycle; obtaining a pre-treatment scan of the target tissue; identifying the reference scan whose phase is consonant with the obtained pre-treatment scan; computing at least one motion vector field between the identified reference scan and another of the plurality of reference scans different from the identified reference scan; applying the at least one computed motion vector field to one of the obtained pre-treatment scan and the another of the plurality of reference scans so as to obtain at least one synthetic scan whose phase is consonant with the other of the obtained pre-treatment scan and the another of the plurality of reference scans; and adjusting one of an irradiation dose, irradiation angle and irradiation positioning responsive to the at least one synthetic scan.

Abstract: A teletherapy control system constituted of: a teletherapy management server; and a computerized tomography unit in communication with the teletherapy management server, the teletherapy management server arranged to: obtain at least one reference image of a target area; obtain from the computerized tomography unit at least one scout image of the target area; compare the obtained at least one scout image of the target area with the obtained at least one reference image of the target area; identify the location coordinates of the target area responsive to the comparison of the obtained scout image with the obtained at least one reference image; and output a control signal to a positioning device responsive to the identified location coordinates of the target area.

Abstract: The invention relates to an imaging system for imaging a region of interest comprising a moving object, which moves less in small motion phases than in large motion phases. Detection values are provided and a small motion determination unit (15) determines the motion of the object in the region of interest in the small motion phases from the 5 detection values. A large motion determination unit (16) determines the motion of the object in the large motion phases from the determined motion of the object in the small motion phases. A reconstruction unit (17) reconstructs an image of the region of interest from the detection values, wherein the reconstruction unit (17) is adapted for performing a motion compensation using the determined motions in the small and large motion phases.

Abstract: Projection data (302) acquired during a tomographic examination of a periodically moving object is used to reconstruct a plurality of image layers (308). The image layers (308) are combined to generate image data at a desired phase of motion. To generate a weighting function used to combine the image layers, a reference weighting function (512) is generated at the desired phase. The image layers (308) are weighted to approximate the first weighting function (312). The number of image layers and the size of a sub-region of interest are advantageously selected so that the various image layers can be stored in a relatively high speed memory portion of a computer.

Abstract: A method of adjusting an irradiation treatment plan, the plan constituted of: obtaining a plurality of reference scans of a target tissue over a breathing cycle; obtaining a pre-treatment scan of the target tissue; identifying the reference scan whose phase is consonant with the obtained pre-treatment scan; computing at least one motion vector field between the identified reference scan and another of the plurality of reference scans different from the identified reference scan; applying the at least one computed motion vector field to one of the obtained pre-treatment scan and the another of the plurality of reference scans so as to obtain at least one synthetic scan whose phase is consonant with the other of the obtained pre-treatment scan and the another of the plurality of reference scans; and adjusting one of an irradiation dose, irradiation angle and irradiation positioning responsive to the at least one synthetic scan.

Abstract: A method for visualizing a region of interest within a viewport includes presenting tomographic image data as an image in a viewport using a set of global image processing operations, presenting a viewing window in the main viewport; and using a second, different set of image processing operations that is local to the viewing window, wherein the second, different set of image processing operations reduces image artifact with respect to a desired structure of interest in the viewing window.

Abstract: The invention relates to an imaging system for imaging a region of interest comprising a moving object, which moves less in small motion phases than in large motion phases. Detection values are provided and a small motion determination unit (15) determines the motion of the object in the region of interest in the small motion phases from the 5 detection values. A large motion determination unit (16) determines the motion of the object in the large motion phases from the determined motion of the object in the small motion phases. A reconstruction unit (17) reconstructs an image of the region of interest from the detection values, wherein the reconstruction unit (17) is adapted for performing a motion compensation using the determined motions in the small and large motion phases.

Abstract: Projection data (302) acquired during a tomographic examination of a periodically moving object is used to reconstruct a plurality of image layers (308). The image layers (308) are combined to generate image data at a desired phase of motion. To generate a weighting function used to combine the image layers, a reference weighting function (512) is generated at the desired phase. The image layers (308) are weighted to approximate the first weighting function (312). The number of image layers and the size of a sub-region of interest are advantageously selected so that the various image layers can be stored in a relatively high speed memory portion of a computer.

Abstract: A coronary arteries tree is approximated by a base sphere (32) which is best fitted to vessels centerlines (38). The base surface (32) is gridded to define pixels (52). The base sphere (32) is mapped to fit the centerlines (38) such that a true form surface (56) is determined. A wall thickness to the true form surface (56) is defined, preferably, by a user. A normal of each pixel (52) is searched for grayscale values of voxels. Each pixel (52) is assigned a maximum of grayscale values of voxels within the defined wall thickness intersected by the corresponding normal. The resulting true form surface is undistorted mode of visualization revealing the arteries tree in its context running on the true surface drawn through the vessels. Mapping the assigned grayscale values onto the base sphere (32) visualizes arteries tree on a globe surface (84) which might be rotatably inspected as a globe. Mapping the assigned grayscale values into a flat surface visualizes arteries tree on a two-dimensional map.