Patents by Inventor Guy Daculsi
Guy Daculsi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Patent number: 8440462Abstract: The invention relates to the use of a silanised hydroxypropylmethylcellulose (HPMC) or silanised hydroxyethylcellulose (HEC) hydrogel, self-crosslinking as a function of pH, for the three-dimensional ex vivo culture of chondrocytes.Type: GrantFiled: May 24, 2010Date of Patent: May 14, 2013Assignees: Institut National de la Sante et de la Recherche Medicale (INSERM), Universite de NantesInventors: Pierre Weiss, Jérôme Guicheux, Guy Daculsi, Gaël Grimandi, Claire Vinatier
-
Patent number: 8044037Abstract: A phosphocalcic compound modified by a gem-bisphosphonic acid or one of its salts, a method for preparing same, as well as its use for preparing an injectable composition. The modified phosphocalcic compound is obtained by adding a gem-bisphosphonic acid or one of its alkali metal or alkaline earth salts to a suspension of a precursor phosphocalcic compound in ultras-pure water, while stirring the reaction medium at room temperature, then in recovering by centrifuging the formed compound. The compound is useful for making an injectable composition, for use in the treatment of bone remodeling equilibrium.Type: GrantFiled: April 14, 2009Date of Patent: October 25, 2011Assignees: Centre National de la Recherche Scientifique, Université de Nantes, Institut National de la Santé et de la Recherche MédicaleInventors: Bruno Bujoli, Solen Josse, Jérôme Guicheux, Pascal Janvier, Jean-Michel Bouler, Guy Daculsi
-
Publication number: 20110189100Abstract: The invention relates to a composition for biomaterials, characterised in that it comprises a calcium phosphate, in which the molar ratio Ca/P is 1 to 2, sintered with a medical imaging contrast agent uniformly distributed in the composition mass. The invention also relates to a method for preparing the same and to the medical uses thereof.Type: ApplicationFiled: October 22, 2008Publication date: August 4, 2011Inventors: Xavier Bourges, Serge Baroth, Guy Daculsi
-
Publication number: 20100297764Abstract: The invention relates to the use of a silanised hydroxypropylmethylcellulose (HPMC) or silanised hydroxyethylcellulose (HEC) hydrogel, self-crosslinking as a function of pH, for the three-dimensional ex vivo culture of chondrocytes.Type: ApplicationFiled: May 24, 2010Publication date: November 25, 2010Inventors: Pierre Weiss, Jérôme Guicheux, Guy Daculsi, Gaël Grimandi, Claire Vinatier
-
Publication number: 20090203648Abstract: A phosphocalcic compound modified by a gem-bisphosphonic acid or one of its salts, a method for preparing same, as well as its use for preparing an injectable composition. The modified phosphocalcic compound is obtained by adding a gem-bisphosphonic acid or one of its alkali metal or alkaline earth salts to a suspension of a precursor phosphocalcic compound in ultras-pure water, while stirring the reaction medium at room temperature, then in recovering by centrifuging the formed compound. The compound is useful for making an injectable composition, for use in the treatment of bone remodeling equilibrium.Type: ApplicationFiled: April 14, 2009Publication date: August 13, 2009Applicants: Centre National de la Recherche Scientifique, Universite de Nantes, Institut National de la Sante et de la Recherche MedicaleInventors: Bruno Bujoli, Solen Josse, Jerome Guicheux, Pascal Janvier, Jean-Michel Bouler, Guy Daculsi
-
Patent number: 7521436Abstract: The invention concerns a phosphocalcic compound modified by a gem-bisphosphonic acid or one of its salts, a method for preparing same, as well as its use for preparing an injectable composition. The modified phosphocalcic compound is obtained by adding a gem-bisphosphonic acid or one of its alkali metal or alkaline earth salts to a suspension of a precursor phosphocalcic compound in ultra-pure water, while stirring the reaction medium at room temperature, then in recovering by centrifuging the formed compound. Said compound is useful for making an injectable composition, for use in the treatment of bone remodeling equilibrium.Type: GrantFiled: February 18, 2003Date of Patent: April 21, 2009Assignees: Centre National de la Recherche Scientifique, Universite de Nantes, Institut National de la Sante et de la Recherche MedicaleInventors: Bruno Bujoli, Solen Josse, Jérôme Guicheux, Pascal Janvier, Jean-Michel Bouler, Guy Daculsi
-
Patent number: 7351280Abstract: A composition and method for producing interconnective macroporous, resorbable and injectable calcium phosphate-based cements (MICPCs). The composition of the invention sets to poorly crystalline apatitic calcium phosphate after mixing a powder component and an aqueous solution. The multiphasic calcium phosphate components in the cement resorb at different rates allowing the timely replacement by new bone. The interconnected macroporosity in the cement allows for vascularization, entrapment of growth factors, cell colonization and tissue ingrowth. This MICPC can be used for dental and medical applications relating to bone repair, augmentation, reconstruction, regeneration, and osteoporosis treatment, and also for drug delivery, and as scaffolds for tissue engineering.Type: GrantFiled: February 9, 2005Date of Patent: April 1, 2008Assignees: New York University, Institut National Dela Sante ET Dela Recherche Medicale, The University of NantesInventors: Ibrahim Khairoun, Racquel Z. LeGeros, Guy Daculsi, Jean-Michael Bouler, Jérôme Guicheux, Olivier Gauthier
-
Publication number: 20070212389Abstract: The invention relates to the use of a silanised hydroxypropylmethylcellulose (HPMC) or silanised hydroxyethylcellulose (HEC) hydrogel, self-crosslinking as a function of pH, for the three-dimensional ex vivo culture of chondrocytes.Type: ApplicationFiled: November 4, 2004Publication date: September 13, 2007Inventors: Pierre Weiss, Jerome Guicheux, Guy Daculsi, Gael Grimandi, Claire Vinatier
-
Publication number: 20050282783Abstract: The invention concerns a phosphocalcic compound modified by a gem-bisphosphonic acid or one of its salts, a method for preparing same, as well as its use for preparing an injectable composition. The modified phosphocalcic compound is obtained by adding a gem-bisphosphonic acid or one of its alkali metal or alkaline earth salts to a suspension of a precursor phosphocalcic compound in ultra-pure water, while stirring the reaction medium at room temperature, then in recovering by centrifuging the formed compound. Said compound is useful for making an injectable composition, for use in the treatment of bone remodeling equilibrium.Type: ApplicationFiled: February 18, 2003Publication date: December 22, 2005Applicant: Centre National de la Recherche ScientifiqueInventors: Bruno Bujoli, Solen Josse, Jerome Guicheux, Pascal Janvier, Jean-Michel Bouler, Guy Daculsi
-
Publication number: 20050199156Abstract: A composition and method for producing interconnective macroporous, resorbable and injectable calcium phosphate-based cements (MICPCs). The composition of the invention sets to poorly crystalline apatitic calcium phosphate after mixing a powder component and an aqueous solution. The multiphasic calcium phosphate components in the cement resorb at different rates allowing the timely replacement by new bone. The interconnected macroporosity in the cement allows for vascularization, entrapment of growth factors, cell colonization and tissue ingrowth. This MICPC can be used for dental and medical applications relating to bone repair, augmentation, reconstruction, regeneration, and osteoporosis treatment, and also for drug delivery, and as scaffolds for tissue engineering.Type: ApplicationFiled: February 9, 2005Publication date: September 15, 2005Inventors: Ibrahim Khairoun, Racquel LeGeros, Guy Daculsi, Jean-Michael Bouler, Jerome Guicheux, Olivier Gauthier
-
Patent number: 6001394Abstract: A biomaterial composition for the resorption/substitution of organic supporting tissues, including 20-75 wt. % of an inorganic phase consisting of particles that include either hydroxyapatite (A) optionally mixed with tricalcium phosphate .beta. (B), or calcium-titaniumphosphate (Ca(Ti).sub.4 (PO.sub.4).sub.6) (C), and 80-25 wt. % of a liquid phase including an aqueous solution of a water-soluble biocompatible polymer that is cross-linkable under the effect of the pH of the medium. The composition is sterilizable, injectable and curable in biological media to form a biomaterial for replacing supporting tissues.Type: GrantFiled: April 13, 1998Date of Patent: December 14, 1999Assignee: Centre National de la Recherche Scientifique (C.N.R.S.)Inventors: Guy Daculsi, Pierre Weiss, Anne Dupraz, Mieczyslam Lapkowski
-
Patent number: 5717006Abstract: Composition for biomaterial for resorption/substitution of support tissues, dental tissues, bone tissues and osteoarticular tissues, which is made up of 40 to 75% by weight of a mineral phase comprising either a mixture of .beta. tricalcium phosphate (A) and hydroxyapatite (B), in a ratio A:B of between 20:80 and 70:30, or calcium titanium phosphate (Ca(Ti).sub.4 (PO.sub.4).sub.6) (C), and 60 to 25% by weight of a liquid phase comprising an aqueous solution of a polymer derived from cellulose. The mineral phase is a powder with a particle size 80 to 200 .mu.m in diameter. Preferably, the liquid phase is hydroxypropyl cellulose, and the concentration of the polymer in the liquid phase is from 0.5 to 4% by weight. The composition is prepared by mixing the mineral phase and the polymer of the liquid phase in an aqueous solution of defined viscosity, and sterilizing the liquid composition thus obtained.Type: GrantFiled: October 10, 1995Date of Patent: February 10, 1998Assignee: Centre National de la Recherche Scientifique (C.N.R.S.)Inventors: Guy Daculsi, Pierre Weiss, Joel Delecrin, Gael Grimandi, Norbert Passuti, Fran.cedilla.ois Guerin
-
Patent number: 5631016Abstract: An integrated solid body of biological interest is produced by admixing a mineral powder with a biologically active principle, and then subjecting the mixture thus obtained to a shockwave thereby to produce an integrated solid body. The shockwave is generated by explosion or by launching a projectile toward the mixture. The mixture is confined in a mold cavity prior to application of the shockwave. The mold cavity is placed under vacuum prior to application of the shockwave. Particles of the mixture are thus cold bonded to each other. The body is in the form of an implant for the human body. The mineral powder is a calcium phosphate, e.g. octocalcium phosphate, dicalcium phosphate, dihydrated dicalcium phosphate, tricalcium phosphate and tetracalcium phosphate.Type: GrantFiled: April 26, 1995Date of Patent: May 20, 1997Assignee: Universite De NantesInventors: Guy Daculsi, Catherine Deudon
-
Patent number: 5543209Abstract: The coating for a prothesis system has a resorbability gradient in the direction perpendicular to the surface of the prothesis system, the internal layer being the least resorbable. It can consist of phospho-calcium material or of two or several successive layers having different resorbabilities and having said resorbability gradient. The prothesis systems covered with the coating according to the invention are used in surgery for the provision of thigh-bone protheses as well as protheses for the facial, ear, nose and throat surgery and the like.Type: GrantFiled: September 22, 1995Date of Patent: August 6, 1996Assignee: Zimmer, Inc.Inventors: Bruno Duquet, Guy Daculsi, Joel Delecrin