Patents by Inventor Guy De Martynoff

Guy De Martynoff has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • IL-15/IL-15RALPHA BASED CONJUGATES PURIFICATION METHOD
    Publication number: 20210009658
    Abstract: The present invention relates to a method for preparing a composition comprising monomeric conjugates from a sample, said conjugate comprising (a) a polypeptide comprising the amino acid sequence of interleukin 15 or derivatives thereof, and (b) a polypeptide comprising the amino acid sequence of the sushi domain of IL-15R? or derivatives thereof; wherein said method comprises the use of anion-exchange chromatography followed by a hydrophobic interaction chromatography; and to a pharmaceutical composition which can be obtained by such a method.
    Type: Application
    Filed: September 18, 2020
    Publication date: January 14, 2021
    Inventors: David Bechard, Guy De Martynoff
  • IL-15/IL-15Ralpha based conjugates purification method
    Patent number: 10808022
    Abstract: The present invention relates to a method for preparing a composition comprising monomeric conjugates from a sample, said conjugate comprising (a) a polypeptide comprising the amino acid sequence of interleukin 15 or derivatives thereof, and (b) a polypeptide comprising the amino acid sequence of the sushi domain of IL-15R? or derivatives thereof; wherein said method comprises the use of anion-exchange chromatography followed by a hydrophobic interaction chromatography; and to a pharmaceutical composition which can be obtained by such a method.
    Type: Grant
    Filed: March 3, 2015
    Date of Patent: October 20, 2020
    Assignee: Cytune Pharma
    Inventors: David Bechard, Guy de Martynoff
  • PURIFIED HEPATITIS C VIRUS ENVELOPE PROTEINS FOR DIAGNOSTIC AND THERAPEUTIC USE
    Publication number: 20080138894
    Abstract: The present invention relates to a method for purifying recombinant HCV single or specific oligomeric envelope proteins selected from the group consisting of E1 and/or E1/E2 characterized in that upon lysing the transformed host cells to isolate the recombinantly expressed protein a disulphide bond cleavage or reduction step is carried out with a disulphide bond cleavage agent. The present invention also relates to a composition isolated by such a method. The present invention also relates to the diagnostic and therapeutic application of these compositions. Furthermore, the invention relates to the use of HCV E1 protein and peptides for prognosing and monitoring the clinical effectiveness and/or clinical outcome of HCV treatment.
    Type: Application
    Filed: February 23, 2007
    Publication date: June 12, 2008
    Applicant: INNOGENETICS N.V.
    Inventors: Geert Maertens, Fons Bosman, Guy De Martynoff, Marie-Ange Buyse
  • Purified hepatitis C virus envelope proteins for diagnostic and therapeutic use
    Publication number: 20070128721
    Abstract: The present invention relates to a method for purifying recombinant HCV single or specific oligomeric envelope proteins selected from the group consisting of E1 and/or E1/E2 characterized in that upon lysing the transformed host cells to isolate the recombinantly expressed protein a disulphide bond cleavage or reduction step is carried out with a disulphide bond cleavage agent. The present invention also relates to a composition isolated by such a method. The present invention also relates to the diagnostic and therapeutic application of these compositions. Furthermore, the invention relates to the use of HCV E1 protein and peptides for prognosing and monitoring the clinical effectiveness and/or clinical outcome of HCV treatment.
    Type: Application
    Filed: January 18, 2007
    Publication date: June 7, 2007
    Applicant: INNOGENETICS N.V.
    Inventors: Geert Maertens, Fons Bosman, Guy De Martynoff, Marie-Ange Buyse
  • Purified hepatitis C virus envelope proteins for diagnostic and therapeutic use
    Patent number: 7026457
    Abstract: The present invention relates to a method for purifying recombinant HCV single or specific oligomeric envelope proteins selected from the group consisting of E1 and/or E1/E2 characterized in that upon lysing the transformed host cells to isolate the recombinantly expressed protein a disulphide bond cleavage or reduction step is carried out with a disulphide bond cleavage agent. The present invention also relates to a composition isolated by such a method. The present invention also relates to the diagnostic and therapeutic application of these compositions. Furthermore, the invention relates to the use of HCV E1 protein and peptides for prognosing and monitoring the clinical effectiveness and/or clinical outcome of HCV treatment.
    Type: Grant
    Filed: October 10, 2001
    Date of Patent: April 11, 2006
    Assignee: Innogenetics N.V.
    Inventors: Geert Maertens, Fons Bosman, Guy De Martynoff, Marie Ange Buyse
  • Purified hepatitis C virus envelope proteins for diagnostic and therapeutic use
    Patent number: 6890737
    Abstract: The present invention relates to a method for purifying recombinant HCV single or specific oligomeric envelope proteins selected from the group consisting of E1 and/or E1/E2, characterized in that upon lysing the transformed host cells to isolate the recombinantly expressed protein a disulphide bond cleavage or reduction step is carried out with a disulphide bond cleavage agent. The present invention also relates to a composition isolated by such a method. The present invention also relates to the diagnostic and therapeutic application of these compositions. Furthermore, the invention relates to the use of HCV E1 protein and peptides for prognosing and monitoring the clinical effectiveness and/or clinical outcome of HCV treatment.
    Type: Grant
    Filed: September 12, 1997
    Date of Patent: May 10, 2005
    Assignee: Innogenetics N.V.
    Inventors: Geert Maertens, Fons Bosman, Guy De Martynoff, Marie-Ange Buyse
  • Purified hepatitis C virus envelope proteins for diagnostic and therapeutic use
    Publication number: 20030036110
    Abstract: The present invention relates to a method for purifying recombinant HCV single or specific oligomeric envelope proteins selected from the group consisting of E1 and/or E1/E2 characterized in that upon lysing the transformed host cells to isolate the recombinantly expressed protein a disulphide bond cleavage or reduction step is carried out with a disulphide bond cleavage agent. The present invention also relates to a composition isolated by such a method. The present invention also relates to the diagnostic and therapeutic application of these compositions. Furthermore, the invention relates to the use of HCV E1 protein and peptides for prognosing and monitoring the clinical effectiveness and/or clinical outcome of HCV treatment.
    Type: Application
    Filed: July 6, 2001
    Publication date: February 20, 2003
    Applicant: INNOGENETICS N.V.
    Inventors: Geert Maertens, Fons Bosman, Guy De Martynoff, Marie-Ange Buyse
  • Purified hepatitis C virus envelope proteins for diagnostic and therapeutic use
    Publication number: 20020182706
    Abstract: The present invention relates to a method for purifying recombinant HCV single or specific oligomeric envelope proteins selected from the group consisting of E1 and/or E1/E2 characterized in that upon lysing the transformed host cells to isolate the recombinantly expressed protein a disulphide bond cleavage or reduction step is carried out with a disulphide bond cleavage agent. The present invention also relates to a composition isolated by such a method. The present invention also relates to the diagnostic and therapeutic application of these compositions. Furthermore, the invention relates to the use of HCV E1 protein and peptides for prognosing and monitoring the clinical effectiveness and/or clinical outcome of HCV treatment.
    Type: Application
    Filed: October 10, 2001
    Publication date: December 5, 2002
    Applicant: Innogenetics NV
    Inventors: Geert Maertens, Fons Bosman, Guy De Martynoff, Marie Ange Buyse
  • Purified hepatitis C virus envelope proteins for diagnostic and therapeutic use
    Patent number: 6245503
    Abstract: The present invention relates to a method for purifying recombinant HCV single or specific oligomeric envelope proteins selected from the group consisting of E1 and/or E1/E2 characterized in that upon lysing the transformed host cells to isolate the recombinantly expressed protein a disulphide bond cleavage or reduction step is carried out with a disulphide bond cleavage agent. The present invention also relates to a composition isolated by such a method. The present invention also relates to the diagnostic and therapeutic application of these compositions. Furthermore, the invention relates to the use of HCV E1 protein and peptides for prognosing and monitoring the clinical effectiveness and/or clinical outcome of HCV treatment.
    Type: Grant
    Filed: September 11, 1997
    Date of Patent: June 12, 2001
    Assignee: N.V. Innogenetics S.A.
    Inventors: Geert Maertens, Fons Bosman, Guy De Martynoff, Marie-Ange Buyse
  • Purified hepatitis C virus envelope proteins for diagnostic and therapeutic use
    Patent number: 6150134
    Abstract: The present invention relates to a method for purifying recombinant HCV single or specific oligomeric envelope proteins selected from the group consisting of E1 and/or E2 and/or E1/E2, characterized in that upon lysing the transformed host cells to isolate the recombination expressed protein a disulphide bond cleavage or reduction step is carried out with a disulphide bond cleavage agent. The present invention also relates to a composition isolated by such a method. The present invention also relates to the diagnostic and therapeutic application of these compositions. Furthermore, the invention relates to the use of HCV E1 protein and peptides for prognosing and monitoring the clinical effectiveness and/or clinical outcome of HCV treatment.
    Type: Grant
    Filed: March 11, 1996
    Date of Patent: November 21, 2000
    Assignee: Innogenetics, N.V.
    Inventors: Geert Maertens, Fons Bosman, Guy De Martynoff, Marie-Ange Buyse