Patents by Inventor Guy de Roo

Guy de Roo has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for purifying Cys-linked antibody-drug conjugates
    Patent number: 10266606
    Abstract: The present invention relates to a method for purifying a mixture of cysteine-linked antibody-drug conjugates, wherein the amount of non-conjugated antibody is in the range of 0-40% by weight, using hydrophobic interaction chromatography (HIC). The mixture is loaded onto a preparative HIC column using a 0.2-1.5 M aqueous salt solution, in which non-conjugated antibody is collected in a flow-through fraction, followed by elution of a purified mixture of cysteine-linked antibody-drug conjugates using a 0-100 mM aqueous salt solution.
    Type: Grant
    Filed: January 9, 2015
    Date of Patent: April 23, 2019
    Assignee: Synthon Biopharmaceuticals B.V.
    Inventors: Guy De Roo, Ruud Martin Verstegen, Rudy Gerardus Elisabeth Coumans
  • METHOD FOR PURIFYING CYS-LINKED ANTIBODY-DRUG CONJUGATES
    Publication number: 20160324979
    Abstract: The present invention relates to a method for purifying a mixture of cysteine-linked antibody-drug conjugates, wherein the amount of non-conjugated antibody is in the range of 0-40% by weight, using hydrophobic interaction chromatography (HIC). The mixture is loaded onto a preparative HIC column using a 0.2-1.5 M aqueous salt solution, in which non-conjugated antibody is collected in a flow-through fraction, followed by elution of a purified mixture of cysteine-linked antibody-drug conjugates using a 0-100 mM aqueous salt solution.
    Type: Application
    Filed: January 9, 2015
    Publication date: November 10, 2016
    Applicant: SYNTHON BIOPHARMACEUTICALS B.V.
    Inventors: Guy DE ROO, Ruud Martin VERSTEGEN, Rudy Gerardus Elisabeth COUMANS
  • EXPRESSION OF SECRETORY IgA ANTIBODIES IN DUCKWEED
    Publication number: 20140359902
    Abstract: Secretory IgA antibodies can be made by expression in a stably-transformed duckweed.
    Type: Application
    Filed: December 14, 2012
    Publication date: December 4, 2014
    Inventors: Gerardus Joseph Andreas Ariaans, Frans van Dalen, Guy De Roo, Declan Thomas Nolan, Jeff Regan
  • Binding peptides: methods for their generation and use
    Publication number: 20060177437
    Abstract: Described are means and methods for generating binding peptide associated with a suitable core region, the resulting proteinaceous molecule and uses thereof. The invention provides a solution to the problems associated with the use of binding molecules over their entire range of use. Binding molecules can be designed to accommodate extreme conditions of use, such as extreme temperatures or pH. Alternatively, binding molecules can be designed to respond to very subtle changes in the environment.
    Type: Application
    Filed: December 9, 2005
    Publication date: August 10, 2006
    Applicant: CatchMabs B.V.
    Inventors: Erwin Houtzager, Wietse Willebrands, Guy de Roo, KeesJan Francoijs, Irma Vijn