Abstract: The invention relates to the field of localized surface analysis, characterization and modification by electrochemistry. It particularly relates to a portable electrochemical microscopy device, to kits comprising such a portable device, and to uses of the portable device and kits. According to the invention, the portable device comprises: a body having a gripping surface for a user and a bearing surface that can be applied to a surface of a substrate to be analyzed; an electrolytic chamber formed in the body and arranged so as to receive an electrolyte, the electrolytic chamber comprising an opening leading to the bearing surface; and a working probe having a distal end arranged in the electrolytic chamber.

Abstract: The invention relates to the field of localized surface analysis, characterization and modification by electrochemistry. It particularly relates to a portable electrochemical microscopy device, to kits comprising such a portable device, and to uses of the portable device and kits. According to the invention, the portable device comprises: a body having a gripping surface for a user and a bearing surface that can be applied to a surface of a substrate to be analyzed; an electrolytic chamber formed in the body and arranged so as to receive an electrolyte, the electrolytic chamber comprising an opening leading to the bearing surface; and a working probe having a distal end arranged in the electrolytic chamber.

Abstract: The present invention relates to a method for grafting, in a covalent manner, a coloured indicator having at least one aromatic primary amine function onto the surface of a solid substrate, including the steps that consist of: (a) preparing, from the coloured indicator having at least one aromatic primary amine function, the corresponding diazonium salt; (b) placing the solid substrate in contact with a solution containing the diazonium salt prepared in step (a) and subjecting the solution to non-electrochemical conditions for an optimal grafting time whereby organic chains in which the units are derivatives of the diazonium salt are grafted, in a covalent manner, onto the surface of the solid substrate; (c) washing the solid substrate thus grafted; (d) repeating steps (b) and (c) or possibly steps (a) to (c) at least once. The present invention also relates to a kit for implementing such a method.

Abstract: The present invention relates to a method for grafting, in a covalent manner, a coloured indicator having at least one aromatic primary amine function onto the surface of a solid substrate, including the steps that consist of: (a) preparing, from the coloured indicator having at least one aromatic primary amine function, the corresponding diazonium salt; (b) placing the solid substrate in contact with a solution containing the diazonium salt prepared in step (a) and subjecting the solution to non-electrochemical conditions for an optimal grafting time whereby organic chains in which the units are derivatives of the diazonium salt are grafted, in a covalent manner, onto the surface of the solid substrate; (c) washing the solid substrate thus grafted; (d) repeating steps (b) and (c) or possibly steps (a) to (c) at least once. The present invention also relates to a kit for implementing such a method.

Abstract: The present invention relates to an implantable material having at least one external surface grafted with a film including carboxylate and sulfonate functions wherein the film is simultaneously synthesized and grafted directly on the external surface by radical reaction of a bifunctional adhesion primer of Formula (I) or by radical reaction of an adhesion primer and a bifunctional polymerizable monomer of Formula (II). The invention also relates to a process for directly synthesizing and grafting of a film according to the invention onto at least one external surface of an implantable material. The invention further relates to the use of a grafted implantable material for the manufacture of an antiproliferative and/or antibacterial implantable medical device. The invention also relates to compounds of Formula (I) and Formula (II).

Abstract: This invention relates to a method for preparing an organic film at the surface of a solid support, with a step of contacting said surface with a liquid solution including (i) at least one solvent, (ii) at least one adhesion primer, under non-electrochemical conditions, and allowing the formation of radical entities based on the adhesion primer. The liquid solution can also include (iii) at least one monomer different from the adhesion primer and radically polymerizable. This invention also relates to a non-electrically-conductive solid support on which an organic film according to said method is grafted, and a kit for preparing an essentially polymeric organic film at the surface of a solid support.

Abstract: A method for modifying the surface energy of at least one surface of a solid is provided. The method may comprise a step consisting of grafting, on the surface, a polymeric organic film consisting of graft polymers, each polymer having a first unit bound directly to the surface derived from a cleavable aryl salt and at least one other unit of the polymer chain derived from a component selected from the group consisting of a cleavable fluorinated aryl salt, a fluorinated (meth)acrylate and a vinyl-terminated siloxane. In addition, a kit for implementation of the method is provided.

Abstract: The present invention relates to an implantable material having at least one external surface grafted with a film including carboxylate and sulfonate functions wherein the film is simultaneously synthesized and grafted directly on the external surface by radical reaction of a bifunctional adhesion primer of Formula (I) or by radical reaction of an adhesion primer and a bifunctional polymerizable monomer of Formula (II). The invention also relates to a process for directly synthesizing and grafting of a film according to the invention onto at least one external surface of an implantable material. The invention further relates to the use of a grafted implantable material for the manufacture of an antiproliferative and/or antibacterial implantable medical device. The invention also relates to compounds of Formula (I) and Formula (II).

Abstract: The invention relates to a method for forming a polymer film on a surface that conducts or semiconducts electricity by means of electrografting. Said method uses an electrolytic solution containing a selected quantity of Bronsted acid. This invention also relates to the electrically conductive or semiconductive surfaces obtained by means of said method.

Abstract: The present invention relates to a process for assembling at least one zone of a first surface with at least one zone of a second surface or with a molecule of interest, comprising a step that consists in placing the said zone of the said first surface in contact with the said zone of the said second surface or with the said molecule of interest, the said zone of the said first surface bearing at least one radical and/or ionic species. The present invention also relates to a solid support whose surface bears at least one zone with at least one radical and/or ionic species, with at least one adhesion primer, or with at least one adhesion primer precursor, and to its various uses.

Abstract: An implantable material has at least one external surface grafted with a film including carboxylate and sulfonate functions wherein the film is simultaneously synthesized and grafted directly on the external surface by radical reaction of a source of carboxylate functions, the source being either polymerizable or chemisorbable and polymerizable and a source of sulfonate functions, the source being either polymerizable or chemisorbable and polymerizable. A process for simultaneously synthesizing and grafting a film directly onto at least one external surface of an implantable material, and the use of a grafted implantable material for the manufacture of an antiproliferative and/or antibacterial implantable medical device are also described.

Abstract: This invention relates to a method for preparing an organic film at the surface of a solid support, with a step of contacting said surface with a liquid solution including (i) at least one protic solvent, (ii) at least one adhesion primer, under non-electrochemical conditions, and allowing the formation of radical entities based on the adhesion primer. The liquid solution can also include (iii) at least one monomer different from the adhesion primer and radically polymerizable. This invention also relates to a non-electrically-conductive solid support on which an organic film according to said method is grafted, and a kit for preparing an essentially polymeric organic film at the surface of a solid support.

Abstract: The present invention relates to the use of precursors of following formula (I): independently of E or Z configuration, in which: R2 is an electron-withdrawing group, R1, R3, R4 and R5, which are identical or different, represent a hydrogen atom, an alkyl radical or an aryl radical, in the formation, by electrochemical grafting, of a homogeneous organic film, preferably with a thickness of less than or equal to 10 nm, on an electrically conducting or semiconducting surface; and to the corresponding process for the formation of an ultrathin homogeneous organic film on an electrically conducting or semiconducting surface.

Abstract: A method for modifying the surface energy of at least one surface of a solid is provided. The method may comprise a step consisting of grafting, on the surface, a polymeric organic film consisting of graft polymers, each polymer having a first unit bound directly to the surface derived from a cleavable aryl salt and at least one other unit of the polymer chain derived from a component selected from the group consisting of a cleavable fluorinated aryl salt, a fluorinated (meth)acrylate and a vinyl-terminated siloxane. In addition, a kit for implementation of the method is provided.

Abstract: The present invention concerns a method for preparing an organic copolymer film on electrically conductive or semi-conductive surfaces in two steps. The first step includes electrolysis of an electrolytic solution containing an adhesion primer, in contact with a surface. The second step corresponds to the reaction, at the surface obtained previously, of a solution containing the following species: a protic solvent, and a “radically polymerizable” monomer. The polymerizable monomer is solubilized in micellar form. The surfaces obtained with the use of this method, and their applications apply to preparation of microelectronic components, biomedical devices or screening kits, as well as kits for preparing an organic copolymer film on an electrically conductive or semi-conductive surface.

Abstract: The present invention concerns the area of surface coatings in the form of organic films, the coatings being in the form of organic films. It most especially relates to a method for forming copolymer organic films by electrochemical grafting on electrically conductive or semi-conductive surfaces using electrolytic aqueous solutions containing at least one protic solvent, at least one radically polymerizable monomer and at least one surfactant. The invention also concerns surfaces obtained with the use of this method, their applications especially for preparation of microelectronic components, biomedical devices or screening kits, as well as the electrolyte solution used in the course of the method.

Abstract: The present invention relates to a process for assembling at least one zone of a first surface with at least one zone of a second surface or with a molecule of interest, comprising a step that consists in placing the said zone of the said first surface in contact with the said zone of the said second surface or with the said molecule of interest, the said zone of the said first surface bearing at least one radical and/or ionic species. The present invention also relates to a solid support whose surface bears at least one zone with at least one radical and/or ionic species, with at least one adhesion primer, or with at least one adhesion primer precursor, and to its various uses.

Abstract: The invention relates to a method of fixing macro-objects to an electricity conducting- or semi-conducting surface by means of electrografting. The invention also relates to the electricity conducting- or semi-conducting-surfaces obtained using the aforementioned method and to the applications of same.

Abstract: This invention relates to a method for preparing an organic film at the surface of a solid support, with a step of contacting said surface with a liquid solution including (i) at least one solvent, (ii) at least one adhesion primer, under non-electrochemical conditions, and allowing the formation of radical entities based on the adhesion primer. The liquid solution can also include (iii) at least one monomer different from the adhesion primer and radically polymerizable. This invention also relates to a non-electrically-conductive solid support on which an organic film according to said method is grafted, and a kit for preparing an essentially polymeric organic film at the surface of a solid support.

Abstract: This invention relates to a method for preparing an organic film at the surface of a solid support, with a step of contacting said surface with a liquid solution including (i) at least one protic solvent, (ii) at least one adhesion primer, under non-electrochemical conditions, and allowing the formation of radical entities based on the adhesion primer. The liquid solution can also include (iii) at least one monomer different from the adhesion primer and radically polymerisable. This invention also relates to a non-electrically-conductive solid support on which an organic film according to said method is grafted, and a kit for preparing an essentially polymeric organic film at the surface of a solid support.