Patents by Inventor Guy H. Harris
Guy H. Harris has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20040242904Abstract: A novel sordarin derivative was isolated from fungal cultures. The compound is useful in the treatment and/or prevention of human and animal fungal infections, as well as in the control of phytopathogenic fungi in crops. Two novel cultures of fungi, ATCC No. PTA-3862 and ATCC No. PTA-3861 can be used to ferment and produce the present compound.Type: ApplicationFiled: June 3, 2004Publication date: December 2, 2004Inventors: Angelo Basilio, Javier Collado, Maria Teresa Diez, Ziqiang Guan, Guy H Harris, Michael C Justice, Jennifer Nielsen-Kahn, Mythili S Shastry
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Patent number: 6228622Abstract: 11-hydroxysordarin, biotransformation product of a fermentation with sordarin and Actinomyces spp., (Merck Culture Collection MA7235) ATCC No. 202103 is an antifungal agent. This compound may be useful in the treatment of diseases caused by fungal pathogens such as Candida albicans.Type: GrantFiled: October 26, 1999Date of Patent: May 8, 2001Assignee: Merck & Co., Inc.Inventors: Michael G. Sturr, Michel M. Chartrain, Guy H. Harris, Jennifer Nielsen-Kahn, Brian Heimbuch
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Patent number: 5972994Abstract: Biotransformation products of a fermentation with Streptomyces sp., (Merck Culture Collection MA7165) ATCC No. 55946 are potent antifungal agents. These products may be useful in the treatment of diseases caused by fungal pathogens such as Candida sp. and Cryptococcus neoformans.Type: GrantFiled: March 24, 1998Date of Patent: October 26, 1999Assignee: Merck & Co., Inc.Inventors: Ali Shafiee, Guy H. Harris, Deborah L. Zink, Janet M. Sigmund, Mark J. Rosenbach, Suzanne Miller Mandala
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Patent number: 5855771Abstract: The present invention relates to a process for separating pyrite from sulfide ores and coal during flotation separation which comprises the depressing of pyrite with from about 0.05 to 0.75 kilograms per ton of concentrate solids, using a pyrite depressant compounds selected from the group consisting ofR1--S (CH.sub.2').sub.n PO (OH).sub.2 (I)wheren is between 2 and 4, andR1 is selected from a group consisting of hydrogen (H) and amidine, and ##STR1## where Ro is a lower alkyl having carbon atoms in a range of 3 to 8 with 3 to 6 being preferred and a final pH in a range of 4 to 9 depending on the ore being processed, and therafter recovering the flotation concentrate thus obtained.Type: GrantFiled: June 17, 1997Date of Patent: January 5, 1999Inventors: Douglas W. Fuerstenau, Guy H. Harris
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Patent number: 5853571Abstract: The present invention relates to a process for separating pyrite from sulfide ores and coal during flotation separation which comprises the depressing of pyrite with from about 0.05 to 0.75 kilograms per ton of concentrate solids using a pyrite depressant compounds selected from the group consisting ofR1, R2, R3 N.sup.+ O.sub.2 H.sub.4 SR4X.sup.- (I)where R1, R2 and R3 are lower alkyls wherein the final sum of the carbon atoms is in a range of 3 to 6, R4 is selected from a group consisting of hydrogen (H) and amidine and X is chlorine, bromine or iodine, ##STR1## where Ro is a lower alkyl having carbon atoms in a range of 3 to 8 with 3 to 6 being preferred and a final pH in a range of 4 to 9 depending on the ore being processed, and therafter recovering the flotation concentrate thus obtained.Type: GrantFiled: June 17, 1997Date of Patent: December 29, 1998Inventors: Guy H. Harris, Douglas W. Fuerstenau
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Patent number: 5846407Abstract: The present invention relates to a process for separating pyrite from sulfide ores and coal during flotation separation which comprises the depression of pyrite with from about 0.125 to 1.250 pounds per ton of 2-S thironium-ethane sulfonate (IESA) as a pyrite depressant. The aforementioned depressant is surprisingly effective in pyrite removal, being substantially independent of the pH values of the treated ore or coal, compatible with conventional collector reagents such as xanthates in the case of copper sulfide bearing ores as well as being substantially unobtrusive in not depressing other useful ore sulfides, including but limited to chalcopyrite, bornite, chalcosite, etc.Type: GrantFiled: June 17, 1997Date of Patent: December 8, 1998Inventors: Douglas W. Fuerstenau, Guy H. Harris
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Patent number: 5801172Abstract: There is disclosed a novel compound having the formula ##STR1## which exhibits antifungal activity.Type: GrantFiled: July 11, 1997Date of Patent: September 1, 1998Assignee: Merck & Co., Inc.Inventors: Wendy H. Clapp-Shapiro, Bruce W. Burgess, Robert A. Giacobbe, Guy H. Harris, Suzanne Mandala, Jon Polishook, Mark Rattray, Rosemary A. Thornton, Deborah L. Zink, Angeles Cabello, Maria Teresa Diez, Isabel Martin, Fernando Pelaez
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Patent number: 5686637Abstract: There is disclosed a novel compound having the formula ##STR1## which exhibits antifungal activity.Type: GrantFiled: January 10, 1995Date of Patent: November 11, 1997Assignee: Merck & Co., Inc.Inventors: Gerald F. Bills, James E. Curotto, S. Dreikorn, Robert A. Giacobbe, Guy H. Harris, Suzanne Miller Mandala, Rosemary A. Thornton, Deborah L. Zink, Angeles Cabello Arroyo, Fernando Pelaez Perez, Teresa Diez Matas, Francisca Vicente Perez
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Patent number: 5597806Abstract: There are disclosed novel compounds having the formula ##STR1## which exhibit antifungal activity.Type: GrantFiled: May 9, 1995Date of Patent: January 28, 1997Assignee: Merck & Co., Inc.Inventors: Wendy H. Clapp, Guy H. Harris, Gerald F. Bills, James E. Curotto, Anne W. Dombrowski, Sarah J. Driekorn, Myra B. Kurtz, Maria S. Meinz, Janet C. Onishi, Jon D. Polishook, Stanley L. Streicher, John R. Thompson, Marie Williams, Deborah L. Zink
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Patent number: 5441987Abstract: A compound having the formula ##STR1## which is useful as an antifungal agent and for the treatment and control of several agricultural phytopathogens, including Phytophthora infestans, is disclosed.Type: GrantFiled: August 12, 1994Date of Patent: August 15, 1995Assignee: Merck & Co., Inc.Inventors: Guy H. Harris, James E. Curotto, Robert A. Giacobbe, Suzanne M. Mandala, Richard L. Monaghan, Richard K. Jansson, Joan A. Lasota
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Patent number: 5364948Abstract: This invention relates to compounds of structural formula (I) isolated from an aerobic fermentation of Trichoderma viride MF5628, ATCC 74084: ##STR1## which are squalene synthase inhibitors and thus useful as cholesterol lowering agents. These compounds are also potent antifungal agents. Additionally, they inhibit farnesyl protein transferase and farnesylation of the oncogene protein Ras and are thus useful in treating cancer. This invention also relates to a process for obtaining compounds of structural formula (I).Type: GrantFiled: February 9, 1993Date of Patent: November 15, 1994Assignee: Merck & Co., Inc.Inventors: Guy H. Harris, Deborah Zink, E. Tracy T. Jones, Yu L. Kong
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Patent number: 5286895Abstract: An acyclic tricarboxylic compound has been isolated from a culture of MF5453. The compound and its derivatives are active as squalene synthetase inhibitors and are useful in the treatment of hypercholesterolemia.Type: GrantFiled: December 7, 1992Date of Patent: February 15, 1994Assignee: Merck & Co., Inc.Inventors: Guy H. Harris, Henry Joshua, Deborah L. Zink
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Patent number: 5262435Abstract: A new Zaragozic acid analog has been isolated from a culture of MF5453. The compound and its derivatives are active as squalene synthetase inhibitors and are useful in the treatment of hypercholesterolemia.Type: GrantFiled: February 10, 1992Date of Patent: November 16, 1993Assignee: Merck & Co., Inc.Inventors: Henry Joshua, Guy H. Harris
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Patent number: 4793852Abstract: This invention relates to a method of recovering non-ferrous metal sulfides from a metal ore which comprises subjecting the metal ore, in the form of an aqueous pulp, to a froth flotation process in the presence of a flotating amount of a flotation collector wherein the collector comprises a compound which corresponds to one of the formulas ##STR1## wherein R.sup.1 is alkyl, aryl or aralkyl group wherein the aryl and aralkyl can be substituted with a halo or alkyl moiety;R.sup.2 is alkyl, aryl or aralkyl group wherein the aryl or aralkyl can be substituted with a halo or alkyl moiety;R.sup.3 is aryl or aralkyl unsubstituted or substituted with a halo or alkyl moiety;R.sup.4 is alkyl, aryl or aralkyl group wherein the aryl or aralkyl can be substituted with a halo or alkyl moiety; with the proviso that at least one of R.sup.1 and R.sup.2 must be aryl or aralkyl unsubstituted or substituted;under conditions such that the metal sulfide values are recovered in the froth.Type: GrantFiled: October 28, 1985Date of Patent: December 27, 1988Assignee: The Dow Chemical CompanyInventors: Guy H. Harris, Patrice K. Ackerman, Frank F. Aplan
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Patent number: 4130477Abstract: A process for the recovery of mineral values by froth flotation in an aqueous medium from mineral ores with the use of an effective amount of a mercaptan polyalkylene oxide frother.Type: GrantFiled: December 21, 1977Date of Patent: December 19, 1978Assignee: The Dow Chemical CompanyInventors: Donald M. Podobnik, Guy H. Harris
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Patent number: 4122004Abstract: A process for the recovery of mineral values by froth flotation in an aqueous medium from mineral ores with the use of an effective amount of a sulfide-containing polyalkylene oxide frother.Type: GrantFiled: November 7, 1977Date of Patent: October 24, 1978Assignee: The Dow Chemical CompanyInventor: Guy H. Harris