Abstract: The present invention relates to peptide compounds that are agonists of the erythropoietin receptor (EPO-R). The invention also relates to therapeutic methods using such peptide compounds to treat disorders associated with insufficient or defective red blood cell production. Pharmaceutical compositions, which comprise the peptide compounds of the invention, are also provided.

Abstract: The present invention relates to peptide compounds that are agonists of the erythropoietin receptor (EPO-R). The invention also relates to therapeutic methods using such peptide compounds to treat disorders associated with insufficient or defective red blood cell production. Pharmaceutical compositions, which comprise the peptide compounds of the invention, are also provided.

Abstract: The present invention relates to peptide compounds that are agonists of the erythropoietin receptor (EPO-R). The invention also relates to therapeutic methods using such peptide compounds to treat disorders associated with insufficient or defective red blood cell production. Pharmaceutical compositions, which comprise the peptide compounds of the invention, are also provided.

Abstract: Novel hemolysin fusion proteins can be produced by inserting a foreign nucleotide sequence encoding an immunogenic peptide in a region of HlyA corresponding to the CnBr II through CnBr V region of HlyA.

Abstract: The invention provides exemplary devices and methods to facilitate the performance of assays. In one embodiment, one such device comprises a holding member having a top surface, a bottom surface, and a plurality of holding locations that are adapted to hold at least one article, such as a solid support and/or a cell. When within the holding locations, the articles are preferably disposed below the top surface. A membrane is positioned above the top surface of the holding member, and a pressure system is provided to apply positive pressure to the membrane to force the membrane against the top surface of the holding member. In this way, a seal may be provided between the holding locations.

Abstract: The invention provides methods for screening libraries of complexes for compounds having a desired property, especially, the capacity to agonize, bind to, or antagonize a cellular receptor. The complexes in such libraries comprise a compound under test, a tag recording at least one step in synthesis of the compound, and a tether susceptible to modification by a reporter molecule. Modification of the tether is used to signify that a complex contains a compound having a desired property. The tag can be decoded to reveal at least one step in the synthesis of such a compound.

Abstract: A bowstring trigger includes a safety lock to prevent premature release of the arrow. Initially, the trigger is cocked by pushing the arrow onto the bowstring thereby causing a bowstring gripper lever to engage the bowstring. In this state, a safety lock lever under the influence of a bias spring moves into the normal path of the trigger lever thereby preventing it from releasing the release lever. A safety release guide string symmetrically attached to opposite sides of the bow handle is connected to the safety release lever and causes it to move out of engagement with the trigger lever when the bowstring is fully withdrawn. With the safety off, the archer can release the bowstring by pushing on the trigger lever with his or her thumb thereby causing the gripper release lever to disengage the bowstring gripper. The bowstring gripper moves forward under the influence of the bowstring and simultaneously releases the arrow in the direction of the target.