Patents by Inventor Guy Marguerite Marie Gerard Nadler
Guy Marguerite Marie Gerard Nadler has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 7491714Abstract: Quinoline and naphthridine derivatives useful in the treatment of bacterial infections in mammals, particularly humans.Type: GrantFiled: December 3, 2003Date of Patent: February 17, 2009Assignee: Glaxo Group LimitedInventors: Jeffrey Michael Axten, Catherine Genevieve Yvette Dartois, Guy Marguerite Marie Gerard Nadler, Neil David Pearson
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Patent number: 7186730Abstract: Piperidine derivatives and pharmaceutically acceptable derivatives thereof useful in methods of treatment of bacterial infections in mammals, particularly man.Type: GrantFiled: May 24, 2002Date of Patent: March 6, 2007Assignee: SmithKline Beecham p.l.c.Inventors: Catherine Genevieve Yvette Dartois, Roger Edward Markwell, Guy Marguerite Marie Gerard Nadler, Neil David Pearson
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Publication number: 20070015766Abstract: Certain compounds of formula (I) below or a pharmaceutically acceptable salt or hydrate thereof: wherein: R1 is H or alkyl; R2 is aryl, cycloalkyl or heteroaryl; R3 is H or C1-3 alkyl, optionally substituted by one or more fluorines; R4 is H, R8NR9R10, R11R13 or R11R12R13; or R5 is branched or linear alkyl, cycloalkyl, aryl, arylalkyl, or a single or fused ring aromatic heterocyclic group; a process for preparing such compounds, a pharmaceutical composition comprising such compounds and the use of such compounds and the use of such compounds and composition in medicine.Type: ApplicationFiled: June 26, 2006Publication date: January 18, 2007Inventors: Carlo Farina, Stefania Gagliardi, Giuseppe Giardina, Mario Grugni, Marisa Martinelli, Guy Marguerite Marie Gerard Nadler
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Patent number: 6903117Abstract: A compound of formula (I): or a salt thereof, or a solvate thereof, wherein Ra represents a group R5 which is hydrogen, alkyl or optionally substituted aryl and Rb represents a moiety of formula (a): wherein X represents a hydroxy or an alkoxy group wherein the alkyl group may be substitued or unsubstituted or X represents a group NRsRt wherein Rs and Rt each independently represent hydrogen, alkyl, substituted alkyl, optionally substituted alkenyl, optionally substituted aryl, optionally substituted arylalkyl, an optionally substituted heterocyclic group or an optionally substituted heterocyclylalkyl group, or Rs and Rt together with the nitrogen to which they are attached form a heterocyclic group; R1 represents an alkyl or a substituted or unsubstituted aryl group; and R2, R3 and R4 each independently represent hydrogen, alkyl, aryl or substituted aryl; R6 and R7 each independently represent hydrogen, hydroxy, amino, alkoxy, optionally substituted aryloxy, optionally substituted benzyloxy, alkylamiType: GrantFiled: November 20, 2002Date of Patent: June 7, 2005Assignee: Nikem Research S.R.L.Inventors: Carlo Farina, Stefania Gagliardi, Guy Marguerite Marie Gerard Nadler
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Publication number: 20040198755Abstract: Piperidine derivatives and pharmaceutically acceptable derivatives thereof useful in methods of treatment of bacterial infections in mammals, particularly man.Type: ApplicationFiled: May 24, 2004Publication date: October 7, 2004Inventors: Catherine Genevieve Yvette Dartois, Roger Edward Markwell, Guy Marguerite Marie Gerard Nadler, Neil David Pearson
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Patent number: 6780875Abstract: A compound, or a solvate or a salt thereof, of formula (I): wherein, Ar is an optionally substituted aryl or a C5-7 cycloalkdienyl group, or an optionally substituted C5-7 cycloalkyl group, or an optionally substituted single or fused ring aromatic heterocyclic group; R is hydrogen, linear or branched C1-6 alkyl, C3-7 cycloalkyl, C3-7 cycloalkylalkyl; R1 represents hydrogen or up to three optional substituents selected from the list consisting of: C1-6 alkyl, C1-6 alkenyl, aryl, C1-6 alkoxy, hydroxy, halogen, nitro, cyano, carboxy, carboxamido, sulphonamido, C1-6 alkoxycarbonyl, trifluoromethyl, acyloxy, amino or mono- and di-C1-6 alkylamino, R2 represents a moiety —(CH2)n—NYY2 wherein n is an integer in the range of from 1 to 9, Y1 and Y2 are independently selected from C1-6-alkyl; C1-6 alkyl substituted with hydroxy, alkoxy, C1-6 alkylamino or bis (C1-6 alkyl) amino; C3-6 cycloalkyl; C4-6 azacycloalkyl; C1-6-alkenyl; aryl or aryl-C1-6-alkyl or Y1 and Y2 together with the nitType: GrantFiled: February 5, 2003Date of Patent: August 24, 2004Assignees: SmithKline Beecham S.p.A., SmithKline Beecham Laboratories PharmaceutiquesInventors: Carlo Farina, Giuseppe Giardina, Mario Grugni, Marcel Morvan, Guy Marguerite Marie GĂ©rard Nadler, Luca Francesco Raveglia
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Publication number: 20040102633Abstract: Certain compounds of formula (I) below or a pharmaceutically acceptable salt or hydrate thereof:Type: ApplicationFiled: September 25, 2003Publication date: May 27, 2004Inventors: Carlo Farina, Giuseppe Giardina, Mario Grugni, Guy Marguerite Marie Gerard Nadler
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Publication number: 20040010012Abstract: A compound of formula (I), or a salt thereof, or a solvate thereof, wherein Ra represents a group R5 which is hydrogen, alkyl or optionally substituted aryl and Rb represents a moiety of formula (a), wherein X represents a hydroxy or an alkoxy group wherein the alkyl group may be substitued or unsubstituted or X represents a group NRsRt wherein Rs and Rt each independently represent hydrogen, alkyl, substituted alkyl, optionally substituted alkenyl, optionally substituted aryl, optionally substituted arylalkyl, an optionally substituted heterocyclic group or an optionally substituted heterocyclylalkyl group, or Rs and Rt together with the nitrogen to which they arm attached form a heterocyclic group; R1 represents an alkyl or a substituted or unsubstituted aryl group; and R2, R3 and R4 each independently represent hydrogen, alkyl, aryl or substituted aryl; R6 and R7 each independently represent hydrogen, hydroxy, amino, alkoxy, optionally substituted aryloxy, optionally substituted benzyloxy, alkylamino, dialType: ApplicationFiled: November 20, 2002Publication date: January 15, 2004Applicant: SmithKline Beecham SpAInventors: Carlo Farina, Stefania Gagliardi, Guy Marguerite Marie Gerard Nadler
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Publication number: 20030212101Abstract: A compound, or a solvate or a salt thereof, of formula (I): 1Type: ApplicationFiled: February 5, 2003Publication date: November 13, 2003Applicant: SmithKline Beecham S.p.A.Inventors: Carlo Farina, Giuseppe Giardina, Mario Grugni, Marcel Morvan, Guy Marguerite Marie Gerard Nadler, Luca Francesco Raveglia
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Patent number: 6613770Abstract: A compound, or a solvate or a salt thereof, of formula (I): wherein R is linear or branched alkyl; R1 represents hydrogen or up to four optional substituents selected from the list consisting of: C1-6 alkyl, C1-6 alkenyl, aryl, C1-6 alkoxy, hydroxy, halogen, nitro, cyano, carboxy, carboxamido, sulphonamido, C1-6 alkoxycarbonyl, trifluoromethyl, acyloxy, phthalimido, amino or mono- and di-C1-6 alkylamino; R2 represents a moiety —(CH2)n—NY1Y2 wherein n is an integer in the range of from 1 to 9, Y1 and Y2 are independently selected from hydrogen; C1-6-alkyl; C1-6 alkyl substituted with hydroxy, C1-6 alkylamino or bis (C1-6 alkyl) amino; C1-6-alkenyl; aryl or aryl-C1-6-alkyl or Y1 and Y2 together with the nitrogen atom to which they are attached represent an optionally substituted N-linked single or fused ring heterocyclic group; R3 is branched or linear C1-6 alkyl, C3-7 cycloalkyl, C4-7 cycloalkylalkyl, optionally substituted aryl, or an optionally substituted single or fused rinType: GrantFiled: September 28, 2001Date of Patent: September 2, 2003Assignees: SmithKline Beecham S.p.A., SmithKline Beecham Laboratoires PhamaceutiquesInventors: Carlo Farina, Giuseppe Giardina, Mario Grugni, Guy Marguerite Marie Gerard Nadler, Luca Francesco Raveglia
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Patent number: 6570037Abstract: A compound of formula (I): or a salt thereof, or a solvate thereof, wherein Ar represents substituted or unsubstituted aryl, wherein the optional substituents are selected from alkyl, hydroxy or alkoxy or, if attached to adjacent carbon atoms any two substituents together with the carbon atoms to which they are attached may form a fused heterocyclic ring of five to six atoms wherein one, two or three of the said atoms are oxygen or nitrogen; A represents a C1-4 n-alkylene group wherein each carbon is optionally substituted by 1 or 2 C1-6 alkyl groups; R1 represents hydrogen, alkyl, alkenyl or cycloalkyl; one or two of of the group of R2, R3 and R4 represents nitro the remaining members of the group of R2, R3 and R4 represent hydrogen; X represents a —CO—NH— moiety; and Z represents C2-4 n-alkylene group wherein each carbon is optionally substituted 1 or 2 C1-6 alkyl groups; a process for preparing such compounds, pharmaceutical compositions comprising such compounds and the use of such compoType: GrantFiled: January 30, 2002Date of Patent: May 27, 2003Assignee: SmithKline Beecham Laboratoires PharmaceutiquesInventors: Guy Marguerite Marie Gerard Nadler, Michel Jean Roger Martin
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Patent number: 6506758Abstract: A compound of formula (I): or a salt thereof, or a solvate thereof, wherein: A represents an optionally substituted aryl group or an optionally substituted heterocyclyl group; Ra represents —CO—NRsRt wherein Rs and Rt each independently represent hydrogen, alkyl, substituted alkyl, optionally substituted alkenyl, optionally substituted aryl, optionally substituted arylalkyl, optionally substituted heterocyclyl or an optionally substituted heterocyclylalkyl group, or Rs and Rt together with the nitrogen to which they are attached form a heterocyclyl group; R1 and R2 each independently represents hydrogen, hydroxy, amino, alkoxy, optionally substituted aryloxy, optionally substituted benzyloxy, alkylamino, dialkylamino, halo, trifluoromethyl, trifluoromethoxy, nitro, alkyl, carboxy, carbalkoxy, carbamoyl, alkylcarbamoyl, or R1 and R2 together represent methylenedioxy, carbonyldioxy or carbonyldiamino; and R3 represents hydrogen, alkanoyl, alkyl, aminoalkyl, hydroxyalkyl, carboxType: GrantFiled: October 11, 2001Date of Patent: January 14, 2003Assignees: SmithKline Beecham Laboratoires Pharmceutiques, SmithKline Beecham SpAInventors: Stefania Gagliardi, Guy Marguerite Marie Gerard Nadler, Pietro A T Novella
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Publication number: 20020173659Abstract: A compound of formula (I): 1Type: ApplicationFiled: December 4, 2001Publication date: November 21, 2002Applicant: Smith Kline Beecham SpAInventors: Carlo Farina, Stefania Gagliardi, Guy Marguerite Marie Gerard Nadler
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Publication number: 20020107243Abstract: A compound of formula (I): or a salt thereof, or a solvate thereof, wherein Ar represents substituted or unsubstituted aryl, wherein the optional substituents are selected from alkyl, hydroxy or alkoxy or, if attached to adjacent carbon atoms any two substituents together with the carbon atoms to which they are attached may form a fused heterocyclic ring of five to six atoms wherein one, two or three of the said atoms are oxygen or nitrogen; A represents a C1-4 n-alkylene group wherein each carbon is optionally substituted by 1 or 2 C1-6 alkyl groups; R1 represents hydrogen, alkyl, alkenyl or cycloalkyl; one or two of of the group of R2, R3 and R4 represents nitro the remaining members of the group of R2, R3 and R4 represent hydrogen; X represents a —CO—NH— moiety; and Z represents C2-4 n-alkylene group wherein each carbon is optionally substituted 1 or 2 C1-6 alkyl groups; a process for preparing such compounds, pharmaceutical compositions comprising such compounds and the use of such compoType: ApplicationFiled: January 30, 2002Publication date: August 8, 2002Applicant: SmithKline Beecham Laboratoires PharmaceutiquesInventors: Guy Marguerite Marie Gerard Nadler, Michel Jean Roger Martin
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Publication number: 20020099080Abstract: A compound of formula (I): 1Type: ApplicationFiled: October 11, 2001Publication date: July 25, 2002Applicant: SmithKline Beecham Laboratoires PharmaceutiquesInventors: Stefania Gagliardi, Guy Marguerite Marie Gerard Nadler, Pietro A. T. Novella
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Publication number: 20010025054Abstract: A compound of formula (I): or a salt thereof, or a solvate thereof, wherein Ar represents substituted or unsubstituted aryl, wherein the optional substituents are selected from alkyl, hydroxy or alkoxy or, if attached to adjacent carbon atoms any two substituents together with the carbon atoms to which they are attached may form a fused heterocyclic ring of five to six atoms wherein one, two or three of the said atoms are oxygen or nitrogen; A represents a C1-4 n-alkylene group wherein each carbon is optionally substituted by 1 or 2 C1-6 alkyl groups; R1 represents hydrogen, alkyl, alkenyl or cycloalkyl; one or two of of the group of R2, R3 and R4 represents nitro the remaining members of the group of R2, R3 and R4 represent hydrogen; X represents a —CO—NH— moiety; and Z represents C2-4 n-alkylene group wherein each carbon is optionally substituted 1 or 2 C1-6 alkyl groups; a process for preparing such compounds, pharmaceutical compositions comprising such compounds and the use of such compoType: ApplicationFiled: April 2, 2001Publication date: September 27, 2001Applicant: SmithKline Beecham p.l.c.Inventors: Guy Marguerite Marie Gerard Nadler, Michel Jean Roger Martin
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Patent number: 6025390Abstract: A compound of formula (I) or a salt thereof, or a solvate thereof, ##STR1## wherein: R.sub.1 represents an alkyl group or a substituted or unsubstituted aryl group; R.sub.2, R.sub.3 and R.sub.4 each independently represent hydrogen, alkyl, aryl or substituted aryl; R.sub.5 and R.sub.6 each independently represent hydrogen, hydroxy, amino, alkoxy, optionally substituted aryloxy, optionally substituted benzyloxy, alkylamino, dialkylamino, halo, trifluoromethyl, trifluoromethoxy, nitro, alkyl, carboxy, carbalkoxy, carbamoyl, alkylcarbamoyl, or R.sub.5 and R.sub.6 together represent methylenedioxy, carbonyldioxy or carbonyldiamino; X represents a hydroxy or an alkoxy group wherein the alkyl group may be substituted or unsubstituted or X represents a group NR.sub.S R.sub.t wherein R.sub.S and R.sub.Type: GrantFiled: June 23, 1999Date of Patent: February 15, 2000Assignees: SmithKline Beecham SpA, SmithKline Beecham FarmaceuticiInventors: Carlo Farina, Stefania Gagliardi, Guy Marguerite Marie Gerard Nadler, Michel Jean Roger Martin
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Patent number: 5985905Abstract: The invention relates to indole compounds, a process for preparing, pharmaceutical compositions containing the compounds and treating diseases associated with over activity of osteoclasts.Type: GrantFiled: May 5, 1999Date of Patent: November 16, 1999Inventors: Carlo Farina, Guy Marguerite Marie Gerard Nadler, Pierfausto Seneci
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Patent number: 5981525Abstract: A compound of formula (I) or a salt thereof, or a solvate thereof, wherein either (i) Ra represents a group R.sub.5 which is hydrogen, alkyl or optionally substituted aryl and R.sub.5 represents a moiety of formula (a); wherein X represents a hydroxy or an alkoxy group wherein the alkyl group may be substituted or unsubstituted or X represents a group NR.sub.s R.sub.t wherein R.sub.s and R.sub.t each independently represent hydrogen, alkyl, substituted alkyl, optionally substituted alkenyl, optionally substituted aryl, optionally substituted arylalkyl, an optionally substituted heterocyclic group or an optionally substituted heterocyclylalkyl group, or R.sub.s and R.sub.t together may form a heterocyclic group; R.sub.1 represents an alkyl or a substituted or unsubstituted aryl group; and R.sub.2, R.sub.3 and R.sub.4 each independently represent hydrogen, alkyl, aryl or substituted aryl or (ii) R.sub.a represents a moiety of the above defined formula (a) and R.sub.b represents the above defined R.sub.5 ; R.Type: GrantFiled: October 9, 1997Date of Patent: November 9, 1999Assignee: SmithKline Beecham CorporationInventors: Carlo Farina, Stefania Gagliardi, Carlo Parini, Mario Pinza, Guy Marguerite Marie Gerard Nadler, Marcel Jean-Marie Morvan
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Patent number: 5977179Abstract: A compound of formula (I), or a salt thereof, or a solvate thereof, wherein Ar represents substituted or unsubstituted aryl, wherein the optional substituents are selected from alkyl, hydroxy or alkoxy or, if attached to adjacent carbon atoms any two substituents together with the carbon atoms to which they are attached may form a fused heterocyclic ring of five to six atoms wherein one, two or three of the said atoms are oxygen or nitrogen; A represents a C.sub.1-4 n-alkylene group wherein each carbon is optionally substituted by 1 or 2 C.sub.1-6 -alkyl groups; R.sub.1 represents hydrogen, alkyl, alkenyl or cycloalkyl; one or two of the group of R.sub.2, R.sub.3 and R.sub.4 represents nitro the remaining members of the group of R.sub.2, R.sub.3 and R.sub.4 represent hydrogen; X represents a --CO--NH-- moiety; and Z represents C.sub.2-4 n-alkylene group wherein each carbon is optionally substituted 1 or 2 C.sub.Type: GrantFiled: July 2, 1997Date of Patent: November 2, 1999Assignee: SmithKline Beecham p.l.c.Inventors: Guy Marguerite Marie Gerard Nadler, Michel Jean Roger Martin