Patents by Inventor Guy Patchornik

Guy Patchornik has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Large scale purification of antibodies
    Patent number: 12454567
    Abstract: A method of isolating an antibody is disclosed. The method comprises contacting an aggregate comprising a hydrophobic chelator, at least one non-ionic detergent, metal ions and a non-detergent hydrophobic agent with a liquid sample comprising the antibody under conditions that allow partitioning of the antibody into the aggregate, thereby isolating the antibody. Kits for isolating antibodies are also disclosed.
    Type: Grant
    Filed: July 27, 2022
    Date of Patent: October 28, 2025
    Assignee: Ariel Scientific Innovations Ltd.
    Inventor: Guy Patchornik
  • Methods of purifying antibodies
    Patent number: 12091445
    Abstract: A method of isolating an antibody is disclosed. The method comprises contacting a hydrophobic chelator, a non-ionic detergent and metal ions so as to generate an aggregate comprising the hydrophobic chelator, the detergent and the metal ions; and contacting the aggregate with a medium comprising the antibody under conditions that allow partitioning of the antibody into the aggregate. Kits for isolating the antibody are also disclosed.
    Type: Grant
    Filed: May 9, 2018
    Date of Patent: September 17, 2024
    Assignees: Ariel Scientific Innovations Ltd., Yeda Research and Development Co. Ltd.
    Inventors: Guy Patchornik, Irishi N. N. Namboothiri, Mordechai Sheves, Assaf Howard, Margalit (Maggie) Cohen
  • LARGE SCALE PURIFICATION OF ANTIBODIES
    Publication number: 20240262890
    Abstract: A method of isolating an antibody is disclosed. The method comprises contacting an aggregate comprising a hydrophobic chelator, at least one non-ionic detergent, metal ions and a non-detergent hydrophobic agent with a liquid sample comprising the antibody under conditions that allow partitioning of the antibody into the aggregate, thereby isolating the antibody. Kits for isolating antibodies are also disclosed.
    Type: Application
    Filed: July 27, 2022
    Publication date: August 8, 2024
    Applicant: Ariel Scientific Innovations Ltd.
    Inventor: Guy PATCHORNIK
  • SCALED-UP METHODS FOR PURIFYING ANTIBODIES
    Publication number: 20240140988
    Abstract: A method of isolating an antibody is disclosed. The method comprises contacting a hydrophobic chelator, a non-ionic detergent and metal ions so as to generate an aggregate comprising the hydrophobic chelator, the detergent and the metal ions; and contacting the aggregate with a medium comprising the antibody under conditions that allow partitioning of the antibody into the aggregate. Kits for isolating the antibody are also disclosed.
    Type: Application
    Filed: April 16, 2020
    Publication date: May 2, 2024
    Applicants: Ariel Scientific Innovations Ltd., Yeda Research and Development Co. Ltd.
    Inventors: Guy PATCHORNIK, Mordechai SHEVES, Irishi N. N. NAMBOOTHIRI, Gunasekaran DHANDAPANI
  • METHODS OF PURIFYING ANTIBODIES
    Publication number: 20200102372
    Abstract: A method of isolating an antibody is disclosed. The method comprises contacting a hydrophobic chelator, a non-ionic detergent and metal ions so as to generate an aggregate comprising the hydrophobic chelator, the detergent and the metal ions; and contacting the aggregate with a medium comprising the antibody under conditions that allow partitioning of the antibody into the aggregate. Kits for isolating the antibody are also disclosed.
    Type: Application
    Filed: May 9, 2018
    Publication date: April 2, 2020
    Applicants: Ariel Scientific Innovations Ltd., Yeda Research and Development Co. Ltd.
    Inventors: Guy PATCHORNIK, Irishi N. N. NAMBOOTHIRI, Mordechai SHEVES, Assaf HOWARD, Margalit (Maggie) COHEN
  • METHODS OF ANALYZING CELL MEMBRANES
    Publication number: 20180319849
    Abstract: A method of precipitating cell membrane fragments from a cell lysate is disclosed. The method comprises contacting the cell lysate with a hydrophobic chelator and a metal ion under conditions that allow precipitation of the cell membrane fragments. Kits for precipitating cell membrane fragments are also disclosed.
    Type: Application
    Filed: July 12, 2018
    Publication date: November 8, 2018
    Applicants: Ariel-University Research and Development Company Ltd., Yeda Research and Development Co. Ltd., Indian Institute of Technology Bombay
    Inventors: Mordechai Sheves, Irishi N. N. Namboothiri, Guy Patchornik
  • Methods of analyzing cell membranes
    Patent number: 10030224
    Abstract: A method of precipitating cell membrane fragments from a cell lysate is disclosed. The method comprises contacting the cell lysate with a hydrophobic chelator and a metal ion under conditions that allow precipitation of the cell membrane fragments. Kits for precipitating cell membrane fragments are also disclosed.
    Type: Grant
    Filed: November 1, 2015
    Date of Patent: July 24, 2018
    Assignees: Ariel-University Research and Development Company Ltd., Yeda Research and Development Co. Ltd., Indian Institute of Technology Bombay
    Inventors: Mordechai Sheves, Irishi N. N. Namboothiri, Guy Patchornik
  • METHODS OF ANALYZING CELL MEMBRANES
    Publication number: 20170121668
    Abstract: A method of precipitating cell membrane fragments from a cell lysate is disclosed. The method comprises contacting the cell lysate with a hydrophobic chelator and a metal ion under conditions that allow precipitation of the cell membrane fragments. Kits for precipitating cell membrane fragments are also disclosed.
    Type: Application
    Filed: November 1, 2015
    Publication date: May 4, 2017
    Inventors: Mordechai SHEVES, Irishi N.N. NAMBOOTHIRI, Guy PATCHORNIK
  • COMPOSITIONS AND METHODS FOR PURIFYING AND CRYSTALLIZING MOLECULES OF INTEREST
    Publication number: 20110256525
    Abstract: A composition-of-matter is provided. The composition comprising at least one antibody binding moiety capable of binding an antibody-labeled target molecule, cell or virus of interest, said at least one antibody binding moiety being attached to at least one coordinating moiety selected capable of directing the composition-of-matter to form a non-covalent complex when co-incubated with a coordinator ion or molecule.
    Type: Application
    Filed: April 11, 2011
    Publication date: October 20, 2011
    Applicant: Affisink Biotechnology Ltd.
    Inventor: Guy PATCHORNIK
  • Compositions and methods for purifying and crystallizing molecules of interest
    Patent number: 7956165
    Abstract: A composition-of-matter is provided. The composition comprising at least one antibody binding moiety capable of binding an antibody-labeled target molecule, cell or virus of interest, said at least one antibody binding moiety being attached to at least one coordinating moiety selected capable of directing the composition-of-matter to form a non-covalent complex when co-incubated with a coordinator ion or molecule.
    Type: Grant
    Filed: July 19, 2007
    Date of Patent: June 7, 2011
    Assignee: Affisink Biotechnology Ltd.
    Inventor: Guy Patchornik
  • Compositions and methods for purifying and crystallizing molecules of interest
    Publication number: 20080108053
    Abstract: A composition-of-matter is provided. The composition comprising at least one antibody binding moiety capable of binding an antibody-labeled target molecule, cell or virus of interest, said at least one antibody binding moiety being attached to at least one coordinating moiety selected capable of directing the composition-of-matter to form a non-covalent complex when co-incubated with a coordinator ion or molecule.
    Type: Application
    Filed: July 19, 2007
    Publication date: May 8, 2008
    Applicant: Affisink Biotechnology Ltd.
    Inventor: Guy Patchornik
  • Compositions and methods for purifying and crystallizing molecules of interest
    Publication number: 20060121519
    Abstract: A composition of matter is provided. The composition includes at least one ligand capable of binding a target molecule or cell of interest, the at least one ligand being attached to at least one coordinating moiety selected capable of directing the composition of matter to form a non-covalent complex when co-incubated with a coordinator ion or molecule. Also provided are methods of using such compositions for target purification, crystallization and immunization.
    Type: Application
    Filed: January 12, 2006
    Publication date: June 8, 2006
    Applicant: Affisink Biotechnology Ltd.
    Inventor: Guy Patchornik