Patents by Inventor Guy R. della-Cioppa
Guy R. della-Cioppa has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 7291767Abstract: This invention relates to putative known and unknown deoxyribonucleic acid (DNA) and amino acid sequences identified in one or more metabolic pathways that lead to dwarfism and stunting in plants and the use of these sequences in agriculture to create dwarf varieties of any plant species. This invention also relates to nucleic acids sequences and polypeptides that produce altered metabolism phenotypes in plants.Type: GrantFiled: July 20, 2001Date of Patent: November 6, 2007Assignee: The Dow Chemical CompanyInventors: J. Vincent B. Oriedo, David McCrery, Philip Savickas, Barbara A. Miller, Randy Pell, Ignacio M. Larrinua, Ted Weglarz, Daniel Gachotte, Avutu S. Reddy, Max Ruegger, Beth Blakeslee, Gregory P. Pogue, Rodney Crosley, Wenjin Zheng, Guy R. Della-Cioppa, Gerson Wolfe
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Patent number: 6987213Abstract: The present invention relates to a method for conferring herbicide, pest, and disease resistance in plant hosts. Specifically, the present invention employs transient viral expression vectors to express proteins or enzymes conferring resistance in plant hosts. In addition, a library of nucleotide sequence variants in a sense or antisene orientation may be used to determine the targets of an herbicide or pathogen and to screen suitable viral nucleic acids for herbicide, pest, and disease resistance.Type: GrantFiled: October 1, 2001Date of Patent: January 17, 2006Assignee: Large Scale Biology CorporationInventors: Monto H. Kumagai, Guy R. della-Cioppa
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Publication number: 20040142477Abstract: The invention provides novel genetic constructions for the expression of inhibitory RNA in the cytoplasm of eukaryotic cells. The inhibitory RNA may be an anti-sense RNA or a co-suppressor RNA, and functions to reduce the expression of a gene of interest in the target cell. The genetic constructions of the invention are capable of replicating in the cytoplasm of a eukaryotic cell and comprise a promoter region in functional combination with an encoding polynucleotide. The genetic constructions may be designed so as to replicate in the cytoplasm of plant cells, yeast cells, and mammalian cells. When the eukaryotic cell of interest is a plant cell, the genetic construction is preferably derived from a plant RNA virus. Plant RNA virus derived genetic constructions may employ a plant virus subgenomic promoter, including subgenomic promoters from tobamoviruses in functional combination with the RNA encoding region.Type: ApplicationFiled: February 6, 2004Publication date: July 22, 2004Applicant: Large Scale Biology CorporationInventors: Monto H. Kumagai, Guy R. Della-Cioppa, Jonathan Donson, Damon A. Harvey, Laurence K. Grill
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Publication number: 20040088762Abstract: This invention relates to putative known and unknown deoxyribonucleic acid (DNA) and amino acid sequences identified in one or more metabolic pathways that lead to dwarfism and stunting in plants and the use of these sequences in agriculture to create dwarf varieties of any plant species. This invention also relates to nucleic acids sequences and polypeptides that produce altered metabolism phenotypes in plants.Type: ApplicationFiled: October 10, 2003Publication date: May 6, 2004Inventors: J. Vincent B. Oriedo, David McCrery, Philip Savickas, Barbara A. Miller, Randy Pell, Ignacio M. Larrinua, Ted Weglarz, Daniel Gachotte, Avutu S. Reddy, Max Ruegger, Beth Blakeslee, Gregory P. Pogue, Rodney Crosley, Wenjin Zheng, Guy R. Della-Cioppa, Wolfe D.W. Gershon
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Patent number: 6720183Abstract: The invention provides novel genetic constructions for the expression of inhibitory RNA in the cytoplasm of eukaryotic cells. The inhibitory RNA may be an anti-sense RNA or a co-suppressor RNA, and functions to reduce the expression of a gene of interest in the target cell. The genetic constructions of the invention are capable of replicating in the cytoplasm of a eukaryotic cell and comprise a promoter region in functional combination with an encoding polynucleotide. The genetic constructions may be designed so as to replicate in the cytoplasm of plant cells, yeast cells, and mammalian cells. When the eukaryotic cell of interest is a plant cell, the genetic construction is preferably derived from a plant RNA virus. Plant RNA virus derived genetic constructions may employ a plant virus subgenomic promoter, including subgenomic promoters from tobamoviruses in functional combination with the RNA encoding region.Type: GrantFiled: March 20, 2002Date of Patent: April 13, 2004Assignee: Large Scale Biology CorporationInventors: Monto H. Kumagai, Guy R. Della-Cioppa, Jonathan Donson, Damon A. Harvey, Laurence K. Grill
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Publication number: 20030167512Abstract: The present invention provides a method of compiling a plant positive sense functional gene profile, a method of changing the phenotype or biochemistry of a plant, a method of determining a change in phenotype or biochemistry of a plant, and a method of determining the presence of a trait in plant. The methods comprise expressing transiently a nucleic acid sequence of a plant into the cytoplasm of a host plant in a plus sense orientation to affect phenotypic or biochemical changes in the host plant. The nucleic acid sequence does not need to be isolated, identified or characterized prior to transfection into the host plant. A viral vector functional genomic screen has been developed to identify nucleotide sequences in transfected plants by systemically overproducing a new protein, or enhancing or suppressing the endogenous gene expression in a plus sense mechanism.Type: ApplicationFiled: September 6, 2002Publication date: September 4, 2003Inventors: Monto H. Kumagai, Guy R. Della-Cioppa, Robert L. Erwin, David R. McGee
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Publication number: 20030077619Abstract: The present invention provides a method of compiling a functional gene profile of an organism, a method of changing the phenotype or biochemistry of a plant, a method of determining a change in phenotype or biochemistry of a plant, a method of determining the presence of a trait in plant, and a method of isolating human cDNA. The methods comprise expressing transiently a nucleic acid sequence of a non-plant donor organism into a host plant by a viral vector to affect phenotypic or biochemical changes in the host plant. The present invention provides a method for discovering the presence of a new gene and determining its function and sequence in a donor organism such as human by transfecting a nucleic acid sequence of the donor organism into a host plant to knock out the endogenous gene expression.Type: ApplicationFiled: May 8, 2002Publication date: April 24, 2003Inventors: Monto H. Kumagai, Guy R. della-Cioppa, Robert L. Erwin, David R. McGee
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Publication number: 20030064392Abstract: The present invention provides a method of compiling a functional gene profile of an organism, a method of changing the phenotype or biochemistry of a plant, a method of determining a change in phenotype or biochemistry of a plant, a method of determining the presence of a trait in plant, and a method of humanizing plant cDNA. The methods comprise expressing transiently a nucleic acid sequence of a non-plant donor organism into a host plant by a viral vector to affect phenotypic or biochemical changes in the host plant. The present invention provides a method for discovering the presence of a new gene and determining its function and sequence in a donor organism such as human by transfecting a nucleic acid sequence of the donor organism into a host plant to knock out the endogenous gene expression.Type: ApplicationFiled: May 22, 2002Publication date: April 3, 2003Inventors: Monto H. Kumagai, Guy R. della-Cioppa, Robert L. Erwin, David R. McGee
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Publication number: 20030041355Abstract: The present invention provides a method of compiling a positive sense functional gene profile of an organism, a method of changing the phenotype or biochemistry of an organism, a method of determining the presence of a trait in an organism, and a method of humanizing a plant cDNA. The methods comprise expressing transiently a nucleic acid sequence of a donor organism into a host plant to affect phenotypic or biochemical changes in the host organism. Once the presence of a trait in a plant is identified by phenotypic or biochemical changes in the host plant, the nucleic acid insert in the cDNA clone or in the vector that results in the changes is then sequenced. The present invention provides a method for discovering new gene and its function in a donor organism such as human by transfecting a nucleic acid sequence of the donor organism into a host organism in a positive sense.Type: ApplicationFiled: May 14, 2002Publication date: February 27, 2003Inventors: Monto H. Kumagai, Guy R. della-Cioppa, Robert L. Erwin, David R. McGee
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Publication number: 20030028926Abstract: The present invention provides a method of compiling a positive sense functional gene profile of an organism, a method of changing the phenotype or biochemistry of an organism, a method of determining a change in phenotype or biochemistry of an organism, and a method of determining the presence of a trait in an organism, and a method of isolating human cDNA. The methods comprise expressing transiently a nucleic acid sequence of a donor organism into a host plant to affect phenotypic or biochemical changes in the host organism. A viral vector functional genomic screen has been developed to identify nucleotide sequences in transfected plants by enhancing or supressing an endogenous gene expression in a positive sense mechanism, or by overexpressing a new protein. Once the presence of a trait in a plant is identified by phenotypic or biochemical changes in the host plant, the nucleic acid insert in the cDNA clone or in the vector that results in the changes is then sequenced.Type: ApplicationFiled: May 1, 2002Publication date: February 6, 2003Inventors: Monto H. Kumagai, Guy R. della-Cioppa, Robert L. Erwin, David R. McGee
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Publication number: 20030027182Abstract: The present invention provides a method of compiling a plant functional gene profile, a method of changing the phenotype or biochemistry of a plant, a method of determining a change in phenotype or biochemistry of a plant, and a method of determining the presence of a trait in plant. The methods comprise expressing transiently a nucleic acid sequence of a plant into a host plant to affect phenotypic or biochemical changes in the host plant. A viral vector functional genomic screen has been developed to identify nucleotide sequences in transfected plants by systemically knocking out endogenous gene expression in an antisense mechanism. Once the presence of a trait in a plant is identified by phenotypic or biochemical changes in the host plant, the nucleic acid insert in the cDNA clone or in the vector that results in the changes is then sequenced. The present invention exemplifies that genes encoding GTP binding proteins in one plant can silence endogenous gene expression in a different plant.Type: ApplicationFiled: March 21, 2002Publication date: February 6, 2003Inventors: Monto H. Kumagai, Guy R. Della-Cioppa, Robert L. Erwin, David R. McGee
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Publication number: 20030027183Abstract: The present invention provides a method of compiling a plant functional gene profile, a method of changing the phenotype or biochemistry of a plant, a method of determining a change in phenotype or biochemistry of a plant, and a method of determining the presence of a trait in plant. The methods comprise expressing transiently a nucleic acid sequence of a plant into a host plant to affect phenotypic or biochemical changes in the host plant. A viral vector functional genomic screen has been developed to identify nucleotide sequences in transfected plants by systemically knocking out endogenous gene expression in an antisense mechanism. Once the presence of a trait in a plant is identified by phenotypic or biochemical changes in the host plant, the nucleic acid insert in the cDNA clone or in the vector that results in the changes is then sequenced. The present invention exemplifies that genes encoding GTP binding proteins in one plant can silence endogenous gene expression in a different plant.Type: ApplicationFiled: April 10, 2002Publication date: February 6, 2003Inventors: Monto H. Kumagai, Guy R. della-Cioppa, Robert L. Erwin, David R. McGee
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Publication number: 20030024008Abstract: The present invention provides a method of compiling a plant functional gene profile, a method of changing the phenotype or biochemistry of a plant, a method of determining a change in phenotype or biochemistry of a plant, a method of determining the presence of a trait in plant, and a method of increasing grain crop. The methods comprise expressing transiently a nucleic acid sequence of a plant into a host plant to affect phenotypic or biochemical changes in the host plant. A viral vector functional genomic screen has been developed to identify nucleotide sequences in transfected plants by systemically knocking out endogenous gene expression in an antisense mechanism. Once the presence of a trait in a plant is identified by phenotypic or biochemical changes in the host plant, the nucleic acid insert in the cDNA clone or in the vector that results in the changes is then sequenced.Type: ApplicationFiled: April 24, 2002Publication date: January 30, 2003Inventors: Monto H. Kumagai, Guy R. Della-Cioppa, Robert L. Erwin, David R. McGee
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Publication number: 20020194646Abstract: The invention is directed to the application of gene sequences which cause a dwarf phenotype in plants to the fields of forestry plants, ornamental horticultural plants, medicinal plants, and Nicotiana plants which are used for purposes other than for traditional tobacco products. The invention provides cDNAs identified by the polynucleotide sequences SEQ ID NO: 1-122 that may be used to create transfected or transgenic plants exhibiting a dwarf phenotype. The invention also provides methods of creating a transfected or transgenic plant exhibiting a dwarf phenotype by expressing in the plant DNA or mRNA identified by the sequences SEQ ID NO:1-122.Type: ApplicationFiled: July 20, 2001Publication date: December 19, 2002Inventors: Gregory P. Pogue, Guy R. Della-Cioppa, Gershon M. Wolfe, Wenjin Zheng
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Patent number: 6479291Abstract: The invention provides novel genetic constructions for the expression of inhibitory RNA in the cytoplasm of eukaryotic cells. The inhibitory RNA may be an anti-sense RNA or a co-suppressor RNA, and functions to reduce the expression of a gene of interest in the target cell. The genetic constructions of the invention are capable of replicating in the cytoplasm of a eukaryotic cell and comprise a promoter region in functional combination with an encoding polynucleotide. The genetic constructions may be designed so as to replicate in the cytoplasm of plant cells, yeast cells, and mammalian cells. When the eukaryotic cell of interest is a plant cell, the genetic construction is preferably derived from a plant RNA virus. Plant RNA virus derived genetic constructions may employ a plant virus subgenomic promoter, including subgenomic promoters from tobamoviruses in functional combination with the RNA encoding region.Type: GrantFiled: March 9, 1999Date of Patent: November 12, 2002Assignee: Large Scale Biology CorporationInventors: Monto H. Kumagai, Guy R. Della-Cioppa, Jonathan Donson, Damon A. Harvey, Laurence K. Grill
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Patent number: 6426185Abstract: The present invention provides a method of compiling a plant functional gene profile, a method of changing the phenotype or biochemistry of a plant, a method of determining a change in phenotype or biochemistry of a plant, and a method of determining the presence of a trait in plant. The methods comprise expressing transiently a nucleic acid sequence of a plant into a host plant to affect phenotypic or biochemical changes in the host plant. A viral vector functional genomic screen has been developed to identify nucleotide sequences in transfected plants by systemically knocking out endogenous gene expression in an antisense mechanism. Once the presence of a trait in a plant is identified by phenotypic or biochemical changes in the host plant, the nucleic acid insert in the cDNA clone or in the vector that results in the changes is then sequenced. The present invention exemplifies that genes encoding GTP binding proteins in one plant can silence endogenous gene expression in a different plant.Type: GrantFiled: July 21, 1999Date of Patent: July 30, 2002Assignee: Large Scale Biology CorporationInventors: Monto H. Kumagai, Guy R. della-Cioppa, Robert L. Erwin, David R. McGee
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Publication number: 20020069429Abstract: The present invention relates to a method for conferring herbicide, pest, and disease resistance in plant hosts. Specifically, the present invention employs transient viral expression vectors to express proteins or enzymes conferring resistance in plant hosts. In addition, a library of nucleotide sequence variants in a sense or antisene orientation may be used to determine the targets of an herbicide or pathogen and to screen suitable viral nucleic acids for herbicide, pest, and disease resistance.Type: ApplicationFiled: October 1, 2001Publication date: June 6, 2002Inventors: Monto H. Kumagai, Guy R. Della-Cioppa
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Patent number: 6376752Abstract: The invention provides novel genetic constructions for the expression of inhibitory RNA in the cytoplasm of eukaryotic cells. The inhibitory RNA may be an anti-sense RNA or a co-suppressor RNA, and functions to reduce the expression of a gene of interest in the target cell. The genetic constructions of the invention are capable of replicating in the cytoplasm of a eukaryotic cell and comprise a promoter region in functional combination with an encoding polynucleotide. The genetic constructions may be designed so as to replicate in the cytoplasm of plant cells, yeast cells, and mammalian cells. When the eukaryotic cell of interest is a plant cell, the genetic construction is preferably derived from a plant RNA virus. Plant RNA virus derived genetic constructions may employ a plant virus subgenomic promoter, including subgenomic promoters from tobamoviruses in functional combination with the RNA encoding region.Type: GrantFiled: November 8, 1999Date of Patent: April 23, 2002Assignee: Large Scale Biology CorporationInventors: Monto H. Kumagai, Guy R. Della-Cioppa, Jonathan Donson, Damon A. Harvey, Laurence K. Grill
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Patent number: 6303848Abstract: The present invention relates to a method for conferring herbicide, pest, and disease resistance in plant hosts. Specifically, the present invention employs transient viral expression vectors to express proteins or enzymes conferring resistance in plant hosts. In addition, a library of nucleotide sequence variants in a sense or antisene orientation may be used to determine the targets of an herbicide or pathogen and to screen suitable viral nucleic acids for herbicide, pest, and disease resistance.Type: GrantFiled: July 21, 1999Date of Patent: October 16, 2001Assignee: Large Scale Biology CorporationInventors: Monto H. Kumagai, Guy R. della-Cioppa
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Publication number: 20010006797Abstract: The invention provides novel genetic constructions for the expression of inhibitory RNA in the cytoplasm of eukaryotic cells. The inhibitory RNA may be an anti-sense RNA or a co-suppressor RNA, and functions to reduce the expression of a gene of interest in the target cell. The genetic constructions of the invention are capable of replicating in the cytoplasm of a eukaryotic cell and comprise a promoter region in functional combination with an encoding polynucleotide. The genetic constructions may be designed so as to replicate in the cytoplasm of plant cells, yeast cells, and mammalian cells. When the eukaryotic cell of interest is a plant cell, the genetic construction is preferably derived from a plant RNA virus. Plant RNA virus derived genetic constructions may employ a plant virus subgenomic promoter, including subgenomic promoters from tobamoviruses in functional combination with the RNA encoding region.Type: ApplicationFiled: March 9, 1999Publication date: July 5, 2001Inventors: MONTO H. KUMAGAI, GUY R. DELLA-CIOPPA, JONATHAN DONSON, DAMON A. HARVEY, LAURENCE K. GRILL