Abstract: Methods and apparatus are provided for automatically adjusting, by an audio device, the SPL of its audio output. As described herein, the SPL is adjusted based on detected ambient noise. According to aspects, audio device iteratively adjusts the SPL based on the ambient noise. According to aspects, the SPL is adjusted to be greater than the ambient noise by a threshold SPL amount. According to aspects, the audio device outputs sound in substantially a first direction and the microphone detects sound substantially outside of the first direction. The adjusted sounds are output by the audio device.

Abstract: Methods, systems, and apparatus, including computer programs encoded on a computer storage medium, for training a classification neural network.

Abstract: The present invention relates to the use of a cannabidiol (CBD) preparation in the treatment of temporal lobe epilepsy. In particular the CBD preparation is characterized by chemical components and/or functional properties that distinguish them from prior CBD compositions. Preferably the CBD used is in the form of a botanically derived purified CBD which comprises greater than or equal to 98% (w/w) CBD and less than or equal to 2% (w/w) of other cannabinoids. The other cannabinoids present are THC at a concentration of less than or equal to 0.1% (w/w); CBD-Cl at a concentration of less than or equal to 0.15% (w/w); CBDV at a concentration of less than or equal to 0.8% (w/w); and CBD-C4 at a concentration of less than or equal to 0.4% (w/w). The botanically derived purified CBD preferably also comprises a mixture of both trans-THC and cis-THC. Alternatively, a synthetically produced CBD is used.

Abstract: A hand held spray dispenser in which air and liquid are pressurised towards a mixing chamber by energy generated by a manual activation element that is rotated with a unidirectional twist to energise one or more energy storage bodies, energy from which is released to generate sufficient air pressure and air flow and sufficient liquid flow for a spray to be formed from the air-liquid mixture.

Abstract: A medical device capable of determining its location is provided. The medical device comprises a memory, one or more antennas, one or more processors coupled with the memory and the one or more antennas, a location manager component executable by the one or more processors. The location manager component is configured to receive first location information from a first location information source and second location information from a second location information source, to rank the first location information source and the second location information source according to a hierarchy of location information sources, the hierarchy of location information sources specifying that the first location information source is of higher rank than the second location information source, determine an approximate location of the medical device based on the first location information, and improve the accuracy of the approximate location based on the second location information.

Abstract: According to some aspects, a wearable device is provided. The wearable device includes a memory, one or more antennas, one or more processors coupled with the memory and the one or more antennas, a location manager component executable by the one or more processors and configured to determine a location of the wearable device, and a direction manager component executable by the one or more processors. The direction manager component may be configured to receive, via the one or more antennas, information descriptive of a location of the medical device, determine a path between the location of the wearable device and the location of the medical device, and provide information descriptive of the path.

Abstract: A perfusion manifold assembly is described that allows for perfusion of a microfluidic device, such as an organ on a chip microfluidic device comprising cells that mimic cells in an organ in the body, that is detachably linked with said assembly so that fluid enters ports of the microfluidic device from a fluid reservoir, optionally without tubing, at a controllable flow rate. A culture module is contemplated that allows the perfusion and optionally mechanical actuation of one or more microfluidic devices, such as organ-on-a-chip microfluidic devices comprising cells that mimic at least one function of an organ in the body.

Abstract: This disclosure includes manifolds, subsea valve modules, and related methods. Some manifolds and/or subsea valve modules include one or more inlets, each configured to receive hydraulic fluid from a fluid source, one or more outlets, each in selective fluid communication with at least one of the inlets, and one or more subsea valve assemblies, each configured to selectively control hydraulic fluid communication from at least one of the inlets to at least one of the outlets, where at least one of the outlets is configured to be in fluid communication with an actuation port of the hydraulically actuated device.

Abstract: Systems and methods for monitoring a file download. The methods include communicating, using a first device, a request to download a file from a source; receiving at the first device a first plurality of packets related to the file; modifying the first plurality of packets to create a second plurality of packets; and communicating the second plurality of packets to a second device configured to reassemble the second plurality of packets, extract the file from the reassembled second plurality of packets, and obtain behavioral data associated with the file. The methods further include receiving at the first device the behavioral data associated with the file, and implementing a download decision based on the behavioral data associated with the file, wherein the implemented download decision indicates at least whether the first device downloads the file.

Abstract: A method involving administering to a phloem sap-feeding insect one or more dsRNAs capable of suppressing activity of one or more RNAi-suppressing nuclease genes expressed in the gut of the insect and one or more dsRNAs capable of suppressing one or more osmoregulatory genes expressed by the insect.

Abstract: A medical device capable of determining its location is provided. The medical device comprises a memory, one or more antennas, one or more processors coupled with the memory and the one or more antennas, a location manager component executable by the one or more processors. The location manager component is configured to receive first location information from a first location information source and second location information from a second location information source, to rank the first location information source and the second location information source according to a hierarchy of location information sources, the hierarchy of location information sources specifying that the first location information source is of higher rank than the second location information source, determine an approximate location of the medical device based on the first location information, and improve the accuracy of the approximate location based on the second location information.

Abstract: According to some aspects, a wearable device is provided. The wearable device includes a memory, one or more antennas, one or more processors coupled with the memory and the one or more antennas, a location manager component executable by the one or more processors and configured to determine a location of the wearable device, and a direction manager component executable by the one or more processors. The direction manager component may be configured to receive, via the one or more antennas, information descriptive of a location of the medical device, determine a path between the location of the wearable device and the location of the medical device, and provide information descriptive of the path.

Abstract: Aspects of the present disclosure are directed toward apparatuses, systems, and methods that include at least one medical device having a device transceiver configured to wirelessly broadcast a device signal including at least unique identifier data and an information system is configured to maintain an active list of medical device inventory associated with a particular emergency response vehicle, and the processor is configured to automatically determine presence of the at least one medical device.

Abstract: This disclosure includes subsea pumping apparatuses and related methods. Some apparatuses include one or more subsea pumps, each having an inlet and an outlet, and one or more motors, each configured to actuate at least one pump to communicate a hydraulic fluid from the inlet to the outlet, where the subsea pumping apparatus is configured to be in fluid communication with a hydraulically actuated device of a blowout preventer. Some subsea pumping apparatuses include one or more of: a desalination system configured to produce at least a portion of the hydraulic fluid; one or more valves, each configured to selectively route hydraulic fluid from an outlet of a pump to, for example, a subsea environment, a reservoir, and/or the inlet of the pump; and a reservoir configured to store at least a portion of the hydraulic fluid. Some apparatuses are configured to be directly coupled to the hydraulically actuated device.

Abstract: The devices, methods and systems are described for providing controlled amounts of gas, gas pressure and vacuum to microfluidic devices the culturing of cells under flow conditions. The devices, methods, and systems contemplated here may also be used to control the environment surrounding the microfluidic devices; offer user control over experiments comprising microfluidic devices, such as the ability to directly or remotely control experiment conditions; and comprise information aggregation and transmission, such that experimental data may be collected, stored, aggregated and transmitted to users.

Abstract: A perfusion manifold assembly is described that allows for perfusion of a microfluidic device, such as an organ on a chip microfluidic device comprising cells that mimic cells in an organ in the body, that is detachably linked with said assembly so that fluid enters ports of the microfluidic device from a fluid reservoir, optionally without tubing, at a controllable flow rate. A culture module is contemplated that allows the perfusion and optionally mechanical actuation of one or more microfluidic devices, such as organ-on-a-chip microfluidic devices comprising cells that mimic at least one function of an organ in the body.

Abstract: A method is disclosed for generating a component mesh of a component that may be built-up layer by layer in an additive manufacturing build-up process. The method includes providing a three-dimensional initial component mesh composed of initial mesh elements of uniform shape which include initial mesh nodes and initial mesh edges extending between the initial mesh nodes; slicing the initial component mesh by at least one cutting plane such that initial mesh elements are divided into at least two resulting mesh elements, wherein at the intersection points of the at least one cutting plane with edges of initial mesh elements resulting mesh nodes are defined; determining the position of each initial mesh element with respect to each cutting plane and thus which initial mesh element is divided into resulting mesh elements and which is not; and determining the shape of each resulting mesh element.

Abstract: Aspects of the present disclosure are directed toward apparatuses, systems, and methods that include at least one medical device having a device transceiver configured to wirelessly broadcast a device signal including at least unique identifier data and an information system is configured to maintain an active list of medical device inventory associated with a particular emergency response vehicle, and the processor is configured to automatically determine presence of the at least one medical device.

Abstract: An automated external defibrillator (AED) includes one or more sensors comprising electrodes configured to couple to a patient and configured to gather medical data from the patient, a display, and a location display system configured to create a device/patient map with map icons comprising an AED location icon and a patient location icon and provide the device/patient map at the display.

Abstract: This disclosure includes subsea pumping apparatuses and related methods. Some apparatuses include one or more subsea pumps, each having an inlet and an outlet, and one or more motors, each configured to actuate at least one pump to communicate a hydraulic fluid from the inlet to the outlet, where the subsea pumping apparatus is configured to be in fluid communication with a hydraulically actuated device of a blowout preventer. Some subsea pumping apparatuses include one or more of: a desalination system configured to produce at least a portion of the hydraulic fluid; one or more valves, each configured to selectively route hydraulic fluid from an outlet of a pump to, for example, a subsea environment, a reservoir, and/or the inlet of the pump; and a reservoir configured to store at least a portion of the hydraulic fluid. Some apparatuses are configured to be directly coupled to the hydraulically actuated device.