Patents by Inventor Guy Salvesen

Guy Salvesen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Fusion proteins and methods of cleavage of such proteins
    Publication number: 20070141662
    Abstract: The invention provides a method of processing recombinant proteins by using aspartate specific proteases.
    Type: Application
    Filed: May 24, 2006
    Publication date: June 21, 2007
    Applicants: Novo Nordisk A/S, The Burnham Institute
    Inventors: Henning Stennicke, Lars Iversen, Guy Salvesen
  • Screening assays for agents that alter inhibitor of apoptosis (IAP) protein regulation of caspase activity
    Publication number: 20070128677
    Abstract: The present invention relates to an action between an inhibitor of apoptosis (IAP) protein and members of the caspase family of cell death proteases, for example, an interaction of the X chromosome linked IAP (XIAP) and caspase-3, caspase-7 or caspase-9, wherein the IAP regulates the activity of the caspases. The invention provides screening assays for identifying agents that alter the specific association of an IAP such as XIAP, c-IAP-1 or c-IAP-2 and a caspase such as caspase-3 or caspase-7. The invention also provides screening assays for identifying agents that alter the specific association of an IAP such as XIAP, c-IAP-1 or c-IAP-2 and a pro-caspase such as pro-caspase-9. In addition, the invention also provides methods for identifying agents that modulate the activity of a caspase in the presence of an IAP and that regulate the activation of a pro-caspase by an IAP.
    Type: Application
    Filed: January 9, 2007
    Publication date: June 7, 2007
    Applicant: The Burnham Institute
    Inventors: John Reed, Quinn Deveraux, Guy Salvesen, Ryosuke Takahashi, Natalie Roy
  • Compositions and methods for the screening pro-apoptotic compounds
    Patent number: 7067274
    Abstract: The present invention is directed to compositions of matter useful for the enhancement of apoptosis in mammals and to methods of using those compositions of matter for the same.
    Type: Grant
    Filed: November 8, 2004
    Date of Patent: June 27, 2006
    Assignees: Genentech, Inc., The Burnham Institute
    Inventors: Wayne J. Fairbrother, Matthew C. Franklin, Heidi Jenii Ackerly Wallweber, Linda Orren Elliott, Saloumeh Kadkhodayan, Domagoj Vucic, Guy Salvesen
  • Compositions and methods for the screening pro-apoptotic compounds
    Publication number: 20050214802
    Abstract: The present invention is directed to compositions of matter useful for the enhancement of apoptosis in mammals and to methods of using those compositions of matter for the same.
    Type: Application
    Filed: November 8, 2004
    Publication date: September 29, 2005
    Applicants: Genentech, Inc., The Burnham Institute
    Inventors: Wayne Fairbrother, Matthew Franklin, Heidi Ackerly Wallweber, Linda Elliott, Saloumeh Kadkhodayan, Domagoj Vucic, Guy Salvesen