Abstract: The present invention relates to methods of treating bladder cancer with human enterovirus C (HEC) in combination with chemotherapy or radiation therapy. The present invention also relates to methods for increasing susceptibility of a cancer cell to infection by HEC.

Abstract: The present invention relates to methods of treating bladder cancer with human enterovirus C (HEC) in combination with chemotherapy or radiation therapy. The present invention also relates to methods for increasing susceptibility of a cancer cell to infection by HEC.

Abstract: The present invention provides a herpes virus which lacks a functional ICP34.5 encoding gene and which comprises two or more of—(i) a gene encoding a prodrug converting enzyme; (ii) a gene encoding a protein capable of causing cell to cell fusion; and (iii) a gene encoding an immunomodulatory protein.

Abstract: An operating system for a non-uniform memory access (NUMA) multiprocessor system that utilizes a software abstraction of the NUMA system hardware representing a hierarchical tree structure to maintain the most efficient level of affinity and to maintain balanced processor and memory loads. The hierarchical tree structure includes leaf nodes representing the job processors, a root node representing at least one system resource shared by all the job processors, and a plurality of intermediate level nodes representing resources shared by different combinations of the job processors. The operating system includes a medium term scheduler for monitoring the progress of active thread groups distributed throughout the system and for assisting languishing thread groups, and a plurality of dispatchers each associated with one of the job processors for monitoring the status of the associated job processor and for obtaining thread groups for the associated job processor to execute.