Patents by Inventor Guy Slutsky

Guy Slutsky has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Insulin producing cells derived from pluripotent stem cells
    Patent number: 9404087
    Abstract: A method of generating islet cells from pluripotent stem cells is disclosed. The method comprises: (a) culturing the pluripotent stem cells in a differentiation medium so as to differentiate the pluripotent stem cells into endoderm cells; and (b) culturing the endoderm cells in a medium comprising at least one growth factor, a cAMP inducer and retinoic acid (RA), said at least one growth factor being selected from the group consisting of FGF10, bFGF and FGF7 so as to generate further differentiated cells; and (c) culturing the further differentiated cells in a medium comprising a maturation factor selected from the group consisting of nicotinamide, GLP-1 and exendin 4, thereby generating islet cells from pluripotent stem cells. Further methods of generating islet cells are also disclosed, isolated cell populations comprising same and uses thereof.
    Type: Grant
    Filed: December 15, 2011
    Date of Patent: August 2, 2016
    Assignee: Kadimastem Ltd.
    Inventors: Michel Revel, Judith Chebath, Guy Slutsky, Alon Levy, Michal Izrael, Arik Hasson, Kfir Molakandov, Rosalia Kaufman
  • INSULIN PRODUCING CELLS DERIVED FROM PLURIPOTENT STEM CELLS
    Publication number: 20130273013
    Abstract: A method of generating islet cells from pluripotent stem cells is disclosed. The method comprises: (a) culturing the pluripotent stem cells in a differentiation medium so as to differentiate the pluripotent stem cells into endoderm cells; and (b) culturing the endoderm cells in a medium comprising at least one growth factor, a cAMP inducer and retinoic acid (RA), said at least one growth factor being selected from the group consisting of FGF10, bFGF and FGF7 so as to generate further differentiated cells; and (c) culturing the further differentiated cells in a medium comprising a maturation factor selected from the group consisting of nicotinamide, GLP-1 and exendin 4, thereby generating islet cells from pluripotent stem cells. Further methods of generating islet cells are also disclosed, isolated cell populations comprising same and uses thereof.
    Type: Application
    Filed: December 15, 2011
    Publication date: October 17, 2013
    Inventors: Michel Revel, Judith Chebath, Guy Slutsky, Alon Levy, Michal Izrael, Arik Hasson, Molakandov Kfir, Rosalia Kaufman