Patents by Inventor Guy Stone

Guy Stone has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11944768
    Abstract: A method of using a catheter assembly for inserting in a fluid filled space in a body includes providing a main body having a first end portion and a second end portion. The first end portion is positioned within the fluid filled space. The second end portion is adjusted to extend outwardly from the fluid filled space when the first end portion is positioned within the fluid filled space. A catheter tip is connected to the second end portion of the main body. The catheter tip includes a housing having a cavity defined therein and a rotating element positioned within the fluid filled space. The rotating element is rotated within the cavity of the housing to impart movement of the first end portion of the main body within the fluid filled space.
    Type: Grant
    Filed: August 17, 2020
    Date of Patent: April 2, 2024
    Assignee: Washington University
    Inventors: Eric Leuthardt, Guy Genin, Matthew Smyth, David Limbrick, Daniel Moran, Lihong Wang, Aaron McLaughlin, Manish Shah, Alexander Yang, Samuel Stone, Devon Haydon, Michael Winek, Richard Marcus
  • Patent number: 7741338
    Abstract: The invention relates to the stabilization of poly-ene macrolides and to a particular macrolide obtained in crystalline form.
    Type: Grant
    Filed: July 6, 2009
    Date of Patent: June 22, 2010
    Assignee: Novartis AG
    Inventors: Francois Navarro, Samuel Petit, Guy Stone
  • Publication number: 20090270441
    Abstract: The invention relates to the stabilization of poly-ene macrolides and to a particular macrolide obtained in crystalline form.
    Type: Application
    Filed: July 6, 2009
    Publication date: October 29, 2009
    Inventors: Francois Navarro, Samuel Petit, Guy Stone
  • Patent number: 7572804
    Abstract: A mixture comprising a poly-ene macrolide and an antioxidant. Preferably, the poly-ene macrolide is rapamycin and the antioxidant is 2,6-di-tert.-butyl-4-methylphenol. The presence of the antioxidant improves the stability of the poly-ene macrolide to oxidation.
    Type: Grant
    Filed: October 11, 2007
    Date of Patent: August 11, 2009
    Assignee: Novartis AG
    Inventors: Francois Navarro, Samuel Petit, Guy Stone
  • Publication number: 20080161334
    Abstract: A mixture comprising a poly-ene macrolide and an antioxidant. Preferably, the poly-ene macrolide is rapamycin and the antioxidant is 2,6-di-tert.-butyl-4-methylphenol. The presence of the antioxidant improves the stability of the poly-ene macrolide to oxidation.
    Type: Application
    Filed: October 11, 2007
    Publication date: July 3, 2008
    Inventors: Francois Navarro, Samuel Petit, Guy Stone
  • Patent number: 7297703
    Abstract: A mixture comprising a poly-ene macrolide and an antioxidant. Preferably, the poly-ene macrolide is rapamycin and the antioxidant is 2, 6-di-tert.-butyl-4-methylphenol. The presence of the antioxidant improves the stability of the poly-ene macrolide to oxidation.
    Type: Grant
    Filed: December 23, 2004
    Date of Patent: November 20, 2007
    Assignee: Novartis AG
    Inventors: Francois Navarro, Samuel Petit, Guy Stone
  • Publication number: 20050288951
    Abstract: This invention allows users to chat online while displaying live webcam images of multiple selected users within an Internet chatroom environment. This technology is unique to the field because: 1) Java Programming Language is used, enabling the program to work across all platforms; 2) the number of users that are allowed to participate in the chatroom is not limited; 3) well-defined Internet standards are used to transfer and display files; 4) webcam images are automatically uniformly sized; 5) users can select the webcam images they want to view from a list of chatters. This invention also discloses a method of providing customer service and the corresponding system utilizing the above-mentioned technology, enabling a customer and representative to interact visually, orally, and/or textually via live webcam images, Voice over Internet Protocol, Instant Messaging System, and/or e-mail.
    Type: Application
    Filed: May 13, 2005
    Publication date: December 29, 2005
    Inventors: Guy Stone, Alexey Suhih
  • Publication number: 20050107418
    Abstract: A mixture comprising a poly-ene macrolide and an antioxidant. Preferably, the poly-ene macrolide is rapamycin and the antioxidant is 2, 6-di-tert.-butyl-4-methylphenol. The presence of the antioxidant improves the stability of the poly-ene macrolide to oxidation.
    Type: Application
    Filed: December 23, 2004
    Publication date: May 19, 2005
    Inventors: Francois Navarro, Samuel Petit, Guy Stone
  • Patent number: 6852729
    Abstract: A mixture comprising a poly-ene macrolide and an antioxidant. Preferably, the poly-ene macrolide is rapamycin and the antioxidant is 2, 6-di-tert.-butyl-4-methylphenol. The presence of the antioxidant improves the stability of the poly-ene macrolide to oxidation.
    Type: Grant
    Filed: March 21, 2003
    Date of Patent: February 8, 2005
    Assignee: Novartis AG
    Inventors: Francois Navarro, Samuel Petit, Guy Stone
  • Publication number: 20030191148
    Abstract: A mixture comprising a poly-ene macrolide and an antioxidant. Preferably, the poly-ene macrolide is rapamycin and the antioxidant is 2, 6-di-tert.-butyl-4-methylphenol. The presence of the antioxidant improves the stability of the poly-ene macrolide to oxidation.
    Type: Application
    Filed: March 21, 2003
    Publication date: October 9, 2003
    Inventors: Francois Navarro, Samuel Petit, Guy Stone
  • Patent number: 6605613
    Abstract: A mixture comprising a poly-ene macrolide and an antioxidant. Preferably, the poly-ene macrolide is rapamycin and the antioxidant is 2,6-di-tert.-butyl-4-methylphenol. The presence of the antioxidant improves the stability of the poly-ene macrolide to oxidation.
    Type: Grant
    Filed: May 29, 2001
    Date of Patent: August 12, 2003
    Assignee: Novartis AG
    Inventors: François Navarro, Samuel Petit, Guy Stone
  • Publication number: 20020032213
    Abstract: A mixture comprising a poly-ene macrolide and an antioxidant. Preferably, the poly-ene macrolide is rapamycin and the antioxidant is 2,6-di-tert.-butyl-4-methylphenol. The presence of the antioxidant improves the stability of the poly-ene macrolide to oxidation.
    Type: Application
    Filed: May 29, 2001
    Publication date: March 14, 2002
    Inventors: Francois Navarro, Samuel Petit, Guy Stone
  • Patent number: 5434281
    Abstract: Process for the stereospecific synthesis of leukotriene B.sub.4 (LTB.sub.4) of 6Z, 8E, 10E configuration of formula ##STR1## in which a dibenzoate triether is prepared which is subjected to a reductive elimination according to the diagram ##STR2## so as to obtain a triether which is converted in order to obtain the leukotriene B.sub.4.
    Type: Grant
    Filed: May 31, 1994
    Date of Patent: July 18, 1995
    Assignee: L'Oreal
    Inventors: Guy Solladie, Guy Stone, Antonio Urbano-Pujol, Jean Maignan
  • Patent number: 5292907
    Abstract: The invention relates to a process for the manufacture of 6-trans-leukotriene B.sub.4 (LTB.sub.4) of formula ##STR1## in which a butadienediol is prepared; the hydroxyl groups are esterified to produce a diester and this diester is subjected to a stereospecific reductive elimination using low valency titanium [Ti(0)] to produce a 6-trans triether of formula: ##STR2## the groups --OA in positions 5 and 12 of which are then converted to --OH groups and the group --CH.sub.2 OA in position of which is then converted to a --COOH group, to produce 6-trans-LTB.sub.4.The invention also relates to intermediates obtained in the said manufacturing process.
    Type: Grant
    Filed: July 20, 1993
    Date of Patent: March 8, 1994
    Assignee: L'Oreal
    Inventors: Jean Maignan, Guy Solladie, Guy Stone