Abstract: A computer-implemented federated studies system and method are disclosed. The system includes: a predefined common data model associated with a study; a set of sites of origin, each associated with a set of input devices for acquiring study data from subjects and a study data device. Each study data device includes: a database for storing study data derived from input devices; a data model translator for translating study data to a common data model format; a common model database for storing, in the data model, individual participant values derived from study data; a study compute module for determining site aggregate values from individual participant values; and an aggregate database for storing site aggregate values. A site of analysis is associated with a study analysis device that includes: an analysis compute module for processing site aggregate values received from sites of origin; and a reporting module for generating study reports.

Abstract: The present disclosure provides computer-implemented methods for annotating a query nucleic acid sequence. Methods of the present disclosure provide for the accurate annotation of nucleic acid sequences having functional or other important implications. Subject methods also provide for generating an assembly for longer DNA sequences that comprise shorter annotated sequences. Also provided are methods for monitoring the genetic material within a defined physical location. Such methods may find use in a variety of applications, for example, monitoring the spread of a pandemic, monitoring the prevalence of antibiotic resistance, provide guidance in making clinical decisions, and others. Also provided are related systems and non-transitory computer-readable recording media.

Abstract: One embodiment of the present invention provides a system that detects denial-of-service attacks by using an execution profile for a kernel of a server computer system. The system produces a run-time execution profile by gathering statistics related to execution of a protocol stack within the kernel, wherein the protocol stack processes packets received from client computer systems. Next, the system compares the run-time execution profile with a normal execution profile, wherein the normal execution profile is representative of execution when the server is not subject to a denial-of-service attack. If the run-time execution profile deviates from the normal execution profile, the system indicates that a denial-of-service attack is taking place.

Abstract: One embodiment of the present invention provides a system that detects denial-of-service attacks by using an execution profile for a kernel of a server computer system. The system produces a run-time execution profile by gathering statistics related to execution of a protocol stack within the kernel, wherein the protocol stack processes packets received from client computer systems. Next, the system compares the run-time execution profile with a normal execution profile, wherein the normal execution profile is representative of execution when the server is not subject to a denial-of-service attack. If the run-time execution profile deviates from the normal execution profile, the system indicates that a denial-of-service attack is taking place.